<b>GLIMMPSE</b>: Online Power Computation for Linear Models with and without a Baseline Covariate

Kreidler, Sarah M.; Muller, Keith E.; Grunwald, Gary K.; Ringham, Brandy M.; Coker-Dukowitz, Zacchary T.; Sakhadeo, Uttara R.; Barón, Anna E.; Glueck, Deborah H.

doi:10.18637/jss.v054.i10

Cited by 266 publications

(174 citation statements)

References 23 publications

(73 reference statements)

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“…Another limitation consisted of the low statistical power of this study for the MPO outcome. Using GLIMMPSE software (University of Colorado Denver; https://glimmpse.samplesizeshop.org/#/), we estimated that 35 (n = 7, 14, and 14 horses for control, firocoxib, and phenylbutazone groups, respectively) to 50 horses (n = 10, 20, and 20 for control, firocoxib, and phenylbutazone horses, respectively) would have been required to have 80% power to detect differences in the observed MPO means with the observed standard deviations . Another limitation of fecal MPO results consists of our inability to attribute those results to distal GI tract inflammation because such pathology was not documented grossly or histologically.…”

Section: Discussionmentioning

confidence: 99%

Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses

et al. 2018

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“…Calculations of group sizes for organ bath experiments were carried out using GLIMMPSE (version 2.2.7, http://glimmpse.samplesizeshop.org), an open‐source online tool for calculating power and sample size, on the basis of own previous experimental data (Hennenberg et al ., ; Kreidler et al ., ; Wang et al ., ; ). Calculations were performed separately for each agonist or EFS.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3

Gratzke

Wang

et al. 2018

British J Pharmacology

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BACKGROUND AND PURPOSEIn men with benign prostatic hyperplasia, increased smooth muscle tone in the prostate may lead to bladder outlet obstruction and subsequent lower urinary tract symptoms. Consequently, medical treatment aims to inhibit prostate smooth muscle contraction. However, the efficacy of the treatment options available is limited, and improved understanding of mechanisms of prostate smooth muscle contraction and identification of new targets for medical intervention are mandatory. Several studies suggest that LIM kinases (LIMKs) promote smooth muscle contraction; however, this has not yet been examined. Here, we studied effects of the LIMK inhibitors on prostate smooth muscle contraction. EXPERIMENTAL APPROACHHuman prostate tissues were obtained from radical prostatectomy. Phosphorylation of cofilin, a LIMK substrate, was examined using a phospho-specific antibody. Smooth muscle contractions were studied in organ bath experiments. KEY RESULTSReal-time PCR, Western blot and immunofluorescence suggested LIMKs are expressed in smooth muscle cells of prostate tissues. Two different LIMK inhibitors, SR7826 (1 μM) and LIMKi3 (1 μM), inhibited contractions of prostate strips, which were induced by electrical field stimulation, α 1 -adrenoceptor agonists phenylephrine and methoxamine and the TXA 2 analogue, U46619. LIMK inhibition in prostate tissues and cultured stromal cells (WPMY-1) was confirmed by cofilin phosphorylation, which was reduced by SR7826 and LIMKi3. In WPMY-1 cells, SR7826 and LIMKi3 caused breakdown of actin filaments and reduced viability. CONCLUSIONS AND IMPLICATIONSSmooth muscle tone in the hyperplastic human prostate may underlie the effects of LIMKs, which promote contraction. Contraction of prostate strips can be inhibited by small molecule LIMK inhibitors.

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“…Data were analyzed using SPSS 23.0 (IBM Corp., Armonk, NY, USA). GLIMMPSE was used for power calculation (Kreidler et al 2013) using covariance and correlation.…”

Section: Data Analysesmentioning

confidence: 99%

Emotional Security and Interparental Conflict: Responses of Adolescents from Different Living Arrangements

López-Larrosa

Sánchez-Souto

et al. 2019

J Child Fam Stud

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Objectives. Interparental conflict (IPC) is linked with adolescents' heightened emotional insecurity about family relations. Our aim was to examine Spanish adolescents' differential responses to IPC as a function of specific dimensions of IPC and emotional security, in two different living arrangements. Methods. Participants were 162 adolescents (M age = 15.55 years), comprising a community sample of 86 adolescents living with their families (CF) and an at-risk sample of 76 adolescents living in residential care (RC). Six video-recorded vignettes depicting everyday IPC were presented, two each of escalated (destructive), constructive, and unresolved conflicts. Multiple dimensions of adolescents' emotional security responses (i.e., emotional reactivity, behavioral regulation, and cognitive representations) were examined. Results. Constructive conflicts generated more intense and positive emotions, more constructive cognitive representations, and a behavioral regulation pattern of higher interference. As expected, destructive conflicts generated negative emotions, destructive cognitive representations, and less interference in both groups. Unresolved conflicts had effects on adolescents that were closer to those of destructive conflict. RC adolescents were more emotionally insecure and reactive in response to constructive conflicts than CF adolescents and exhibited a blunted pattern of response to destructive conflicts, even when overall levels of emotional security were controlled. Sensitization to constructive conflict also appeared in adolescents low in emotional security. Girls evidenced greater involvement, less positivity and more negativity than boys. Conclusions. Our results have implications for understanding RC adolescents' greater risk for adjustment problems and for broadening the scope of Emotional Security Theory in future research to include additional living arrangements.

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GLIMMPSE: Online Power Computation for Linear Models with and without a Baseline Covariate

Cited by 266 publications

References 23 publications

Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses

Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses

Inhibition of human prostate smooth muscle contraction by the LIM kinase inhibitors, SR7826 and LIMKi3

Emotional Security and Interparental Conflict: Responses of Adolescents from Different Living Arrangements

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