Proliferation of the b -Cells of Pancreas in Diabetic Rats Treated with Urtica Dioica

Golalipour, Mohammad Jafar; Ghafari, Soraya; Kouri, V.; Kestkar, Abbas Ali

doi:10.4067/s0717-95022010000200011

Cited by 15 publications

(12 citation statements)

References 21 publications

(19 reference statements)

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“…In addition to the above-mentioned herbs, a number of others has been found to have potential protective or regenerative properties on beta cells: Abroma augusta (Mir, Darzi, Mir, 2013), Alchornea cordifolia (EliakimIkechukwu, Obri, 2009), Amaranthus caudatus (Girija et al, 2011), Amaranthus spinosus (Girija et al, 2011), Amaranthus viridis (Girija et al, 2011), Artanema sesamoides (Selvan et al, 2008), Bauhinia variegata (Koti et al, 2009), Cassia alata (Eliakim-Ikechukwu et al, 2013, Cassia occidentalis (Verma et al, 2010), Clitoria ternatea (Verma, Itankar, Arora , 2013), Elephantopus scaber (Daisy et al, 2007), Epicatechin (Chakravarthy, Gupta, Gode, 1982), Leucaena leucocephala (DarmonoSyamsudin, Simanjuntak, 2006), Mangiferin (Wang et al, 2014), Morus alba (Mohammadi, Prakash, 2008), Prangos ferulacea (Soltani Band et al, 2011), Pterocarpus marsupium (Chakravarthy et al, 1980), Sansevieria trifasciata (Qomariyah, Sarto, Pratiwi, 2012), Syzygium cumini (Singh, Gupta, 2007a), Teucrium polium (Yazdanparast, Esmaeili, Ashrafi, 2005), Thunbergia laurifolia (Aritajat, Wuteerapol, Saenphet,, 2004), Tinospora cordifolia (Rajalakshmi et al, 2009), Trigonella foenum-graceum (Kulkarni et al, 2012), Vinca rosea (Ahmed et al, 2010), Urtica dioica (Golalipour et al, 2010), and Urtica pilulifera (Kavalali et al, 2003). However, for each one, only one study from independent authors was found to support their protective or regenerative effects on beta cells.…”

Section: Other Plants With Protective Effects On Pancreasmentioning

confidence: 99%

Pancreatic beta cell protection/regeneration with phytotherapy

Hosseini

Shafiee-Nick

Ghorbani

2015

Braz. J. Pharm. Sci.

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Although currently available drugs are useful in controlling early onset complications of diabetes, serious late onset complications appear in a large number of patients. Considering the physiopathology of diabetes, preventing beta cell degeneration and stimulating the endogenous regeneration of islets will be essential approaches for the treatment of insulin-dependent diabetes mellitus. The current review focused on phytochemicals, the antidiabetic effect of which has been proved by pancreatic beta cell protection/regeneration. Among the hundreds of plants that have been investigated for diabetes, a small fraction has shown the regenerative property and was described in this paper. Processes of pancreatic beta cell degeneration and regeneration were described. Also, the proposed mechanisms for the protective/ regenerative effects of such phytochemicals and their potential side effects were discussed. Embora medicamentos disponíveis atualmente sejam úteis no controle de complicações da Diabetes, complicações aparecem em grande número de pacientes. Considerando-se a fisiopatologia do Diabetes, a prevenção da degeneração de células beta e o estímulo da regeneração endógena de ilhotas será abordagem essencial para o tratamento de diabetes mellitus insulino-dependente. A presente revisão aborda compostos fitoquímicos, cujo efeito é provado na proteção/regeneração de células beta de pâncreas. Entre centenas de plantas que têm sido investigadas para o diabetes, pequena fração tem mostrado propriedade regenerativa, que será descrita neste trabalho. Os processos de degeneração e de regeneração das células beta do pâncrease são descritos. Além disso, mecanismos propostos para efeitos de proteção e regeneração desses compostos fitoquímicos e seus possíveis efeitos colaterais também serão discutidos neste trabalho.Unitermos: Diabetes mellitus/tratamento. Diabetes mellitus/fitoterapia. Fitoterapia/Diabetes mellitus. Ilhotas/regeneração endógena. Células beta/proteção. Células beta/regeneração. Pâncreas. Plantas medicinais/propriedades regenerativas.

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Section: Other Plants With Protective Effects On Pancreasmentioning

confidence: 99%

Pancreatic beta cell protection/regeneration with phytotherapy

Hosseini

Shafiee-Nick

Ghorbani

2015

Braz. J. Pharm. Sci.

View full text Add to dashboard Cite

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“…Several studies have suggested that an increase in glucose uptake by skeletal muscles and also adipose tissues is the major cause of a reduction in blood glucose concentrations after UD consumption (18). It is also suggested that UD has the anti-inflammatory activities that can affect the functional status of the pancreatic β-cells, insulin release, an increase in the uptake of glucose by the cells, and ultimately the blood glucose concentration reduction (20). In addition to the anti-inflammatory activity of the UD, its antioxidant characteristic may be associated with the more intestinal absorption of glucose to cells (16).…”

Section: Discussionmentioning

confidence: 99%

“…Farzami et al (13) have shown that the aqueous extract of UD may affect the release of insulin from pancreas beta cells in streptozotocin (STZ)-induced diabetic rats. Golalipour et al (20) reported that pretreatment with the UD hydro-alcoholic extract (100 mg/kg -1 /day -1 ) in the STZ-induced rats might increase proliferation rate of β-cells. As free radicals are involved to impair the pancreatic β-cells, they suggested that the results are probably related to the antioxidant properties of UD extract which can inhibit or scavenge the activity of free radicals.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Urtica dioica Hydro-Alcoholic Extract on Glycemic Index and AMP-Activated Protein Kinase Levels in Diabetic Patients: A Randomized Single-Blind Clinical Trial

Korani

Mirzapour

Moghadamnia

et al. 2016

Iran Red Crescent Med J

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Background: Type 2 diabetes (T2DM) is an endocrine disease caused by inadequate secretion or improper utilization of insulin. Studies have shown that AMP-activated protein kinase (AMPK) dysregulation is contributed to the development of T2DM. Urtica dioica (UD) may have anti-hypoglycemic activities in T2DM patients. However, the underlying mechanism is remained unclear. The aim of this study was to assess the UD effect on serum levels of glucose, glycated hemoglobin (HbA1c), insulin concentration, and AMPK levels in diabetic patients.

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“…STZ in fresh 0.1 mol/L citrate buffer (pH 4.5) was administered intraperitoneally at a single dose of 80 mg/kg to establish diabetic rat model [31]. The control rats were also intraperitoneally administered with the citrate buffer.…”

Section: Experimental Designmentioning

confidence: 99%

“…Rats with diabetes were confirmed after fasting blood glucose levels exceeded 11.1 mmol/L. The curcumin treated group was put on a normal diet plus 1.5 g curcumin/kg body weight administered orally by intragastric intubation daily for 21 days [31][32][33].…”

Section: Experimental Designmentioning

confidence: 99%

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

Xie

Zeng

et al. 2017

Open Life Sciences

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Abstract:We investigated the effect of curcumin on liver anti-oxidative stress in the type 1 diabetic rat model induced by streptozotocin (STZ). Experimental diabetic rats were induced by STZ intraperitoneally. All rats were fed for 21 days including three groups of control (NC), diabetic model (DC) and curcumin-treated (Cur, 1.5 g/kg by gavage). The results showed that curcumin-treatment significantly decreased the blood glucose and plasma malondialdehyde levels, but significantly increased the plasma superoxide dismutase, glutathione peroxidase and reduced glutathione levels. Curcumin treatment decreased the activity of aldose reductase, but increased the plasma glucose-6-phosphate dehydrogenase, glucose synthetase and glucose-polymerizing activities. Curcumin treatment significantly decreased the protein of protein kinase C (PKC) and poly ADP ribose polymerase (PARP) expression in the Cur group compared with the DC group. Moreover, the sorbitol dehydrogenase activity was significantly decreased and deterred glucose enters into the polyol pathway leading to an increased NADPH content in the Cur group compared with the DC group. Our data provides evidence that oxidative stress in diabetic rats may be attenuated by curcumin by inhibiting polyol pathway associated with down-regulated expression of PKC and PARP, as evidenced by both an increase the antioxidant enzymes levels and glycogen biosynthesis enzymes activities.

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Proliferation of the b -Cells of Pancreas in Diabetic Rats Treated with Urtica Dioica

Cited by 15 publications

References 21 publications

Pancreatic beta cell protection/regeneration with phytotherapy

Pancreatic beta cell protection/regeneration with phytotherapy

The Effect of Urtica dioica Hydro-Alcoholic Extract on Glycemic Index and AMP-Activated Protein Kinase Levels in Diabetic Patients: A Randomized Single-Blind Clinical Trial

Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

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