Curcumin attenuates oxidative stress in liver in Type 1 diabetic rats

Abstract

Abstract:We investigated the effect of curcumin on liver anti-oxidative stress in the type 1 diabetic rat model induced by streptozotocin (STZ). Experimental diabetic rats were induced by STZ intraperitoneally. All rats were fed for 21 days including three groups of control (NC), diabetic model (DC) and curcumin-treated (Cur, 1.5 g/kg by gavage). The results showed that curcumin-treatment significantly decreased the blood glucose and plasma malondialdehyde levels, but significantly increased the plasma superoxide dismutase, glutathione peroxidase and reduced glutathione levels. Curcumin treatment decreased the activity of aldose reductase, but increased the plasma glucose-6-phosphate dehydrogenase, glucose synthetase and glucose-polymerizing activities. Curcumin treatment significantly decreased the protein of protein kinase C (PKC) and poly ADP ribose polymerase (PARP) expression in the Cur group compared with the DC group. Moreover, the sorbitol dehydrogenase activity was significantly decreased and deterred glucose enters into the polyol pathway leading to an increased NADPH content in the Cur group compared with the DC group. Our data provides evidence that oxidative stress in diabetic rats may be attenuated by curcumin by inhibiting polyol pathway associated with down-regulated expression of PKC and PARP, as evidenced by both an increase the antioxidant enzymes levels and glycogen biosynthesis enzymes activities.

Microglia Specific Drug Targeting Using Natural Products for the Regulation of Redox Imbalance in Neurodegeneration

“…The phytochemical curcumin is a free radical scavenger and hydrogen donor and exhibits both pro-oxidant and antioxidant activity. In the experimental diabetic rats induced by streptozotocin (STZ), the effect of curcumin on liver antioxidative stress showed inhibition of polyol pathway associated with down-regulated expression of protein kinase C (PKC) and poly ADP ribose polymerase (PARP) in the curcumin-treated group compared with the diabetic model (Xie et al, 2017). Curcumin directly reacts and scavenge reactive oxygen species (such as superoxide anion, hydroxyl radicals, hydrogen peroxide, singlet oxygen, nitric oxide, peroxynitrite and peroxyl radicals).…”

The effect of melatonin on glycoprotein levels and oxidative liver injury in experimental diabetes

“…This is because sorbitol (which is the substrate of SDH) is generated by the activity of reductase. Xie et al [ 43 ] showed that plasma SDH and AR, as well as the activities of the enzymes in the liver increased in the diabetic group. Khorsand et al [ 44 ] demonstrated that Mel prevented STZ‐induced hyperglycemia by decreasing blood glucose and HbA1c levels.…”