Proliferation of Mouse Fibroblasts Induced by 1,2-Dimethylhydrazine Auto-Oxidation: Role of Iron and Free Radicals

Gamberini, Márcia; Leite, Luciana C. C.

doi:10.1006/bbrc.1997.6577

Cited by 12 publications

(7 citation statements)

References 15 publications

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“…DMH is extensively metabolized in vivo and toxicity has been ascribed to metabolism-generated reactive intermediates, such as alkyldiazonium ions, carbon-centred radicals and ROS (Gamberini & Leite, 1997).…”

Section: Resultsmentioning

confidence: 99%

Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice

LeBlanc¹,

LeBlanc²,

Perdigón

et al. 2008

Journal of Medical Microbiology

116

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Section: Resultsmentioning

confidence: 99%

Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice

LeBlanc¹,

LeBlanc²,

Perdigón

et al. 2008

Journal of Medical Microbiology

116

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“…• by prolonged auto-oxidation of hydrazine derivatives induced proliferation of cultured mouse fibroblasts [28]. However, in addition to this proliferative effect of O 2 • forced onto cells by exogenous manipulation, it has been recently described that oxygen species may also act as second messengers transducing growth stimulatory effects to the nucleus.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin II-mediated expression of p27Kip1 and induction of cellular hypertrophy in renal tubular cells depend on the generation of oxygen radicals

Hannken

Schroeder

Stahl

et al. 1998

Kidney International

156

112

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This study provides the first evidence, to our knowledge, that Ang II induces O2. in cultured tubular cells. Ang II-mediated activation of membrane bound NAD(P)H oxidase, probably by an increase in p22phox transcripts, is likely responsible for this induction. Generation of O2. subsequently induces p27Kip1 expression and stimulates hypertrophy, suggesting a novel mechanism of how Ang II can modulate cell cycle regulation.

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“…Recently, some investigators [7,8] reported that ROS induce cell proliferation at low doses. Moreover, it was shown [9,10] that hydrogen peroxide effects on the human c-fos promoter and the proto-oncogene c-fos appear to be essential for proliferation.…”

Section: Introductionmentioning

confidence: 99%

Increase of the Cellular Growth of Old Human Diploid Fibroblasts by Radical Scavenger: Water-Soluble Protein from Broad Beans

Okada¹,

Okada

1999

Gerontology

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There is increasing evidence that free radical scavengers play an important role in the aging process and the control of cellular growth. We purified a free radical scavenging protein, the water-soluble protein (WSP) from broad beans (Vicia faba). In this study, we examined the effect of WSP on cellular growth and in vitro life span in old human fetal lung fibroblasts (WI-38 and PDL 37-40, 78–84% of the maximum life span). Since WSP increased the cellular growth, we also examined the effect of WSP (1.25–5 µg/ml) on cytosolic antioxidant enzyme activities in the old cells treated or not with tert-butyl hydroperoxide (BHP) to elucidate the mechanisms of cell proliferation in the old cells. The cellular growth of old fibroblasts was greatly increased by WSP. In 1.25 and 2.5 µg/ml of WSP, the cell proliferation increased by 32 and 35%, respectively, as compared with controls. The maximum population doubling levels of the cells did not increase. In the cells incubated with BHP, the cytosolic superoxide dismutase activity was returned to its control value by WSP treatment (1.25–5 µg/ml). The cytosolic glutathione peroxidase activity progressively increased with increasing concentrations of WSP. On the other hand, the cytosolic superoxide dismutase activity after 1.25- and 2.5-µg/ml WSP treatment without BHP was increased by 189 and 144%, respectively. Similarly, the cytosolic glutathione peroxidase activity was increased by 67 and 53%, respectively. These results suggest that cytosolic antioxidant activities in old cells can be modulated by WSP treatment. We concluded that there was a correlation between the optimum WSP concentrations for the increase of cellular growth and the WSP concentrations required to exhibit these maximum enzyme activities.

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Proliferation of Mouse Fibroblasts Induced by 1,2-Dimethylhydrazine Auto-Oxidation: Role of Iron and Free Radicals

Cited by 12 publications

References 15 publications

Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice

Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice

Angiotensin II-mediated expression of p27Kip1 and induction of cellular hypertrophy in renal tubular cells depend on the generation of oxygen radicals

Increase of the Cellular Growth of Old Human Diploid Fibroblasts by Radical Scavenger: Water-Soluble Protein from Broad Beans

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