Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice

LeBlanc, Alejandra de Moreno de; LeBlanc, Jean Guy; Perdigón, Gabriela; Miyoshi, Anderson; Langella, Philippe; Azevedo, Vasco; Sesma, Fernando

doi:10.1099/jmm.0.47403-0

Cited by 116 publications

(50 citation statements)

References 25 publications

(22 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…lactis has no catalase, Rochat et al [61] introduced the B. subtilis heme catalase KatE gene into this industrially important microorganism giving rise to a strain capable of producing active catalase that can provide efficient antioxidant activity. A recent report has shown that this genetically engineered strain was able to prevent tumor appearance in an experimental DMH-induced colon cancer model [66]. The catalase producing Lc.…”

Section: Genetically Engineered Lab-antioxidant Enzyme and Il-10 Prodmentioning

confidence: 99%

“…lactis + KatE GM CAT Slight increase in catalase activities in the intestines and prevention of colon cancer of mice administered the cancer inducing drug DMH. [66] Lc.lactis NZ9800 and L.plantarum NCIMB8826 + pNZ804 sodA GM SOD Reduction in macroscopic damages in rats administered with TNBS to induce colitis [72] ( [74]…”

Section: Genetically Engineered Lab-antioxidant Enzyme and Il-10 Prodmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

LeBlanc¹,

Carmen²,

Zurita-Turk³

et al. 2012

AIA

Self Cite

View full text Add to dashboard Cite

Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that have been shown to possess therapeutic properties since they are able to prevent the development of some diseases, as shown mostly on animal models for cancer, infections and gastrointestinal disorders such as intestinal inflammation. LAB have been shown to regulate mucosal immune responses by modulating the production and liberation of regulatory agents such as cytokines by the host. Some of these cytokines, such as the anti-inflammatory interleukin-10 (IL-10), modulate the inflammatory immune response, thus immunomodulation is a mechanism by which LAB can prevent certain inflammatory bowel diseases (IBD). Since oxidative stress participates in the inflammatory processes and in the appearance of damages in pathologies of the gastrointestinal tract of humans such as IBD, LAB could also prevent inflammation by eliminating reactive oxygen species (ROS) through the activity of antioxidant enzymes. In order to obtain novel strains or enhance beneficial effects of LAB, genetic engineering has been used to produce either antioxidant enzymes (such as catalases and superoxide dismutases) or anti-inflammatory cytokines (such as IL-10) producing LAB. These novel strains have successfully been used to prevent inflammatory bowel diseases in animal models and could be evaluated in human clinical trials. Here, we present an overview of the current knowledge of the mechanisms by which LAB can be used to prevent undesired intestinal inflammatory responses and could be used as a therapeutic tool for IBD.

show abstract

Section: Genetically Engineered Lab-antioxidant Enzyme and Il-10 Prodmentioning

confidence: 99%

Section: Genetically Engineered Lab-antioxidant Enzyme and Il-10 Prodmentioning

confidence: 99%

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

LeBlanc¹,

Carmen²,

Zurita-Turk³

et al. 2012

AIA

Self Cite

View full text Add to dashboard Cite

show abstract

“…We have previously shown that the catalase-producing Lc. lactis strain was able to prevent tumor appearance in the colon [118]. In another study, we have shown that a catalase producing strain of L. casei BL23 significantly decreased the physiological damages caused by the TNBS administration [121].…”

Section: Antioxidant Enzyme-producingmentioning

confidence: 86%

Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

Carmen

LeBlanc

Miyoshi

et al. 2011

Ulcers

Self Cite

View full text Add to dashboard Cite

Lactic acid bacteria (LAB) represent a heterogeneous group of microorganisms that are naturally present in many foods and possess a wide range of therapeutic properties. The aim of this paper is to present an overview of the current expanding knowledge of the mechanisms by which LAB and other probiotic microorganisms participate in the prevention and treatment of inflammatory bowel diseases. These include changes in the gut microbiota, stimulation of the host immune responses, and reduction of the oxidative stress due to their antioxidant properties. A brief overview of the uses of genetically engineered LAB that produce either antioxidant enzymes (such as catalase and superoxide dismutase) or anti-inflammatory cytokines (such as IL-10) will also be discussed. This paper will show that probiotics should be considered in treatment protocols of IBD since they provide many beneficial effects and can enhance the effectiveness of traditional used medicines.

show abstract

“…Previously, our group has demonstrated that recLAB were effective in the treatment and/or prevention of IBD in animal models after conferring them the capacity to produce anti-oxidant enzymes such as catalase (CAT) or superoxide dismutase (SOD) (de Moreno de LeBlanc et al, 2008;del Carmen et al, 2014a) or the anti-inflammatory cytokine IL-10 (del Carmen et al, , 2014b. Also, the effectiveness of recLAB for the local delivery of IL-10 DNA and the subsequent production of the cytokine by host cells has also been shown (del Pontes et al, 2012;Zurita-Turk et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the biosafety of recombinant lactic acid bacteria designed to prevent and treat colitis

LeBlanc

Carmen

Châtel

et al. 2016

Journal of Medical Microbiology

Self Cite

View full text Add to dashboard Cite

Oral administration of a catalase-producing Lactococcus lactis can prevent a chemically induced colon cancer in mice

Cited by 116 publications

References 25 publications

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

Mechanisms Involved in the Anti-Inflammatory Properties of Native and Genetically Engineered Lactic Acid Bacteria

Potential Application of Probiotics in the Prevention and Treatment of Inflammatory Bowel Diseases

Evaluation of the biosafety of recombinant lactic acid bacteria designed to prevent and treat colitis

Contact Info

Product

Resources

About