Proliferation and Maturation of Human Bone Marrow Cellsin Infectious Diseases

Dormer, Peter G.; Hültner, Lothar; Mergenthaler, H.-G.

doi:10.1016/s0344-0338(11)81022-8

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…It rather reflects the alterations occurring in the much larger bone marrow progenitor cell compartment. With regard to the time frame, pool size, and cell production rate reported by other authors, this increase in circulating progenitors is due not only to a mobilization of GM-CFC from bone marrow to the peripheral blood, but also to a real expansion of the progenitor compartment (4,7,25).…”

Section: Discussionmentioning

confidence: 65%

Cytokines and progenitor cells of granulocytopoiesis in peripheral blood of patients with bacterial infections

Selig

Nothdurft

1995

Infect Immun

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To investigate the physiological role of granulocyte colony-stimulating factor (G-CSF) and granulocytemacrophage colony-stimulating factor (GM-CSF) in the adaptation mechanisms of myelopoiesis to enhanced demand, we studied both cytokines and their myeloid target cells in hematologically healthy patients suffering from acute bacterial infections. Endogenous serum levels of G-CSF and GM-CSF, granulocyte-macrophage colony-forming cell (GM-CFC) concentrations, and differential counts were determined for the peripheral blood of 57 patients with clinically apparent bacterial infections (26 males and 31 females aged 16 to 89 years) and 18 healthy controls (8 males and 10 females aged 23 to 84 years). Patients were selected for acute-phase protein and at least two additional clinical signs reflecting a bacterial infection. Patients showed significantly higher numbers of myeloid progenitor cells than controls (median, 68 versus 26 GM-CFC/ml; P Յ 0.01). G-CSF but not GM-CSF levels were found to be elevated (Ն50 to 863 pg/ml). In the acute stage of infection, progenitor and cytokine levels were not influenced by gender, differences in therapy, or localization of the infection. Progenitor and G-CSF levels were not associated with absolute neutrophil counts or C-reactive protein. However, a negative correlation between number of GM-CFC per milliliter and age (R ‫؍‬ ؊0.47; P Յ 0.001) and an inverse relationship between the incidence of high GM-CFC concentrations and elevated G-CSF levels (phi ‫؍‬ ؊0.34; P Յ 0.01) were found. Combining both parameters into a cytokine-progenitor pattern, we observed a highly significant age-dependent response of myelopoiesis to inflammation (P Յ 0.001). Younger patients had high progenitor counts (>75 GM-CFC/ml) associated with G-CSF levels below 50 pg/ml, whereas for the older patients, the reverse pattern was predominant. The results indicate that the age-dependent myelopoietic response to acute bacterial infections is characterized by an inverse relationship between progenitor cells and G-CSF. The observed cytokine-progenitor patterns could have implications for therapy with G-CSF and the prognosis of infectious diseases.

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Section: Discussionmentioning

confidence: 65%