Acrylamide tissue distribution and genotoxic effects in a common viral infection in mice

Evaluation of Some Renal Function Parameters in Rats Treated with Acrylamide

“…As a result of these assessments, acrylamide is classified as "possible human carcinogen" (Group 2A) by IARC [1]. It was clearly revealed as a result of in vivo and in vitro experiments that acrylamide and its basic metabolite, glycidamide, have genotoxic and clastogenic effects [5,[28][29][30]. Large intestine, bladder and kidney are the organs that are more target to the acrylamide incoming body via foods because acrylamide and its basic metabolite, glycidamide are detoxified by glutathione conjugation, absorbed rapidly by digestion system after dissolving in water and removed from the body via urine [1].…”

Acrylamide and 5-hydroxymethylfurfural (HMF): A review on metabolism, toxicity, occurrence in food and mitigation strategies

“…After ingestion, acrylamide is rapidly absorbed and distributed in animals and humans throughout the whole body. It can be found in many organs such as the thymus, liver, heart, brain, kidneys (AbramsonZetterberg, Wong, & Ilbäck, 2005), as well as in human placenta (Schettgen et al, 2004) and breast milk (Sorgel et al, 2002), thus being easily transferable to fetus or newborn infants. Acrylamide can be either oxidized by cytochrome P450 2E1 into the epoxide glycidamide (2,3-epoxypropionamide) (Friedman, 2003;Sumner et al, 1999) or conjugated with glutathione (GSH) (Sumner, MacNeela, & Fennell, 1992).…”

Interactions Among Infections, Nutrients and Xenobiotics

“…5 and 6). For instance, Ni is accumulated in the pancreas and heart (Ilback et al, 1992a), Cd in the spleen and kidneys (Ilback et al, 1992b), TCDD in the brain and thymus (Funseth and Ilback, 1994), acrylamide in the blood and thymus (Abramsson-Zetterberg et al, 2005), and PBDE in the liver (Darnerud et al, 2005). When Hg or Ni (Ilback et al, 1994a;Ilback et al, 1996), but not Cd (Ilback et al, 1994b), is administered in food during coxsackievirus infection, inflammatory lesions and damage to the heart are increased.…”

“…8). Accordingly, even in the same coxsackievirus infection, TCDD (Funseth and Ilback, 1994;Funseth et al, 2002a), PBDE (Darnerud et al, 2005) and acrylamide (Abramsson-Zetterberg et al, 2005), that are detoxified by P450 enzymes, each exhibit its own specific target organ distribution.…”