PROLIFERATION AND APOPTOSIS OF B-CELL LYMPHOMA CELLS UNDER TARGETED REGULATION OF FOXO3 BY miR-155

Zheng, Xiaoqiang; Rui, Hong-Bing; Liu, Ying; Dong, Jinpei

doi:10.4084/mjhid.2020.073

Cited by 9 publications

(9 citation statements)

References 29 publications

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“…During these years, many studies have reported that miR-155 was directly bound up with the occurrence and development of DLBCL. Therefore, miR-155 was expected to become a treatment target for DLBCL patients to improve the treatment effect on patients and the prognosis [ 75 , 76 ]. To support this hypothesis, a further study demonstrated that miR-155 promoted B cell lymphoma cell proliferation and inhibited cell apoptosis through targeting inhibition of FOXO3, and both miR-155 overexpression and FOXO3 low-expression were related to poor prognosis in patients with DLBCL [ 77 , 78 ].…”

Section: Mir-155 and Inflammationmentioning

confidence: 99%

miR-155: An Important Role in Inflammation Response

Huang

Liu

et al. 2022

Journal of Immunology Research

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MicroRNAs (miRNAs) are a class of small, mature, noncoding RNA that lead to posttranscriptional gene silencing to regulate gene expression. miRNAs are instrumental in biological processes such as cell development, cell differentiation, cell proliferation, and cell apoptosis. The miRNA-mediated gene silencing is an important part of the regulation of gene expression in many kinds of diseases. miR-155, one of the best-characterized miRNAs, has been found to be closely related to physiological and pathological processes. What is more, miR-155 can be used as a potential therapeutic target for inflammatory diseases. We analyze the articles about miR-155 for nearly five years, review the advanced study on the function of miR-155 in different inflammatory cells like T cells, B cells, DCs, and macrophages, and then summarize the biological functions of miR-155 in different inflammatory cells. The widespread involvement of miR-155 in human diseases has led to a novel therapeutic approach between Chinese and Western medicine.

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Section: Mir-155 and Inflammationmentioning

confidence: 99%

miR-155: An Important Role in Inflammation Response

Huang

Liu

et al. 2022

Journal of Immunology Research

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“…Moreover, we also found that the expression of RASIP1 is regulated by forkhead box O3 (FOXO3), which has been reported with a cancer suppressive role in multiple tumors, including DLBCL 20 . FOXO3 generally acts as a transcription factor activating or suppressing the transcription of downstream genes 21 , 22 .…”

Section: Introductionmentioning

confidence: 54%

Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells

Xing

Wang

Liu

et al. 2023

Cancer Biology & Therapy

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A GTPase binding protein, Ras interacting protein 1 (RASIP1), has been reported with a tumor-promoting role in lung cancer cells, and its role in lymphoma remains unknown. The analysis of medical databank shows that RASIP1 is upregulated in diffuse large B-cell lymphoma (DLBCL) specimens. In this article, we demonstrated that RASIP1 is highly expressed in DLBCL cell lines, compared with primary B cells. The gain- and loss-of-function experiments were performed to investigate the effects of RASIP1 on DLBCL cells. CCK-8, flow cytometry, western blot, and transwell assays demonstrated that silence of RASIP1 inhibited proliferation, cell cycle transition, and invasion and induced significant apoptosis in DLBCL cells, and ectopic expression of RASIP1 played opposite roles. Xenograft results revealed that RASIP1 facilitated the growth of DLBCL cells in vivo . These findings suggest that RASIP1 may be required for malignancy of DLBCL cells. In addition, we also found that the expression of RASIP1 was negatively regulated by forkhead box O3 (FOXO3), which has been reported to suppress the proliferation of DLBCL cells. Our results indicate that FOXO3 is bound to the promoter sequence of RASIP1 and inhibits its transcription. The suppressive effects of FOXO3 on proliferation and invasion of DLBCL cells were neutralized by RASIP1. In conclusion, we demonstrate that FOXO3 negatively regulated RASIP1 facilitates growth and invasion of DLBCL cells, provides novel diagnostic markers and therapeutic targets for DLBCL in clinic.

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“…It has been reported that FOXO3 inhibited tumorigenesis by suppressing the expression of proliferation-related genes, including CCND1 (27) and CCNA1 (28), and inducing the expression of apoptotic genes, including BIM (29) and NOXA (30). The loss of FOXO3 expression significantly accelerates B lymphomagenesis in MYC-mutant mice (31), and the silencing of FOXO3 inhibits the apoptosis of DLBCL cells (17). In the present study, the ectopic expression of FOXO3 induced the apoptosis, and attenuated the proliferation and cell cycle transition of DLBCL cells.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, forkhead box O3 (FOXO3) has been reported to function as a tumor suppressor in various cancer types, including gastric (14), prostate (15) and lung cancer (16). A recent study reported that the silencing of FOXO3 promoted the proliferation and inhibited the apoptosis of DLBCL cells (17). As a transcription factor, FOXO3 simultaneously functions as a transcription enhancer and suppressor.…”

Section: Introductionmentioning

confidence: 99%

Promoting effects of calponin 3 on the growth of diffuse large B‑cell lymphoma cells

et al. 2023

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Diffuse large B-cell lymphoma (DLBCL) is one of the most common types of lymphoma. Calponin 3 (CNN3) is a thin filament-associated protein previously known to regulate smooth muscle contraction. Recent evidence illustrates its involvement in carcinogenesis; however, its roles in DLBCL remain unknown. CNN3 was found to be highly expressed in DLBCL specimens according to the online Gene Expression Profiling Interactive Analysis data. The aim of the present study was to investigate the roles of CNN3 in the progression of DLBCL. In vitro, the ectopic expression of CNN3 promoted the proliferation and G1/S transition of DLBCL cells, while its silencing led to opposite alterations. A similar tumor-promoting role of CNN3 was also demonstrated by injecting nude mice with DLBCL cells over-or underexpressing CNN3. The results of dual-luciferase reporter and chromatin immunoprecipitation assays revealed that forkhead box O3 (FOXO3), a known tumor suppressor in DLBCL, bound to the CNN3 promoter at -1955/-1948 and -1190/-1183, and suppressed the transcription of CNN3. The alterations induced by FOXO3 were partly blocked by CNN3 overexpression. On the whole, the present study demonstrates that CNN3, whose transcriptional activity is negatively regulated by FOXO3, contributes to the malignant behavior of DLBCL cells. The findings of the present study may provide novel diagnostic or therapeutic insight for DLBCL in clinical practice.

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PROLIFERATION AND APOPTOSIS OF B-CELL LYMPHOMA CELLS UNDER TARGETED REGULATION OF FOXO3 BY miR-155

Cited by 9 publications

References 29 publications

miR-155: An Important Role in Inflammation Response

miR-155: An Important Role in Inflammation Response

Ras interacting protein 1 facilitated proliferation and invasion of diffuse large B-cell lymphoma cells

Promoting effects of calponin 3 on the growth of diffuse large B‑cell lymphoma cells

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