miR-155: An Important Role in Inflammation Response

Abstract

MicroRNAs (miRNAs) are a class of small, mature, noncoding RNA that lead to posttranscriptional gene silencing to regulate gene expression. miRNAs are instrumental in biological processes such as cell development, cell differentiation, cell proliferation, and cell apoptosis. The miRNA-mediated gene silencing is an important part of the regulation of gene expression in many kinds of diseases. miR-155, one of the best-characterized miRNAs, has been found to be closely related to physiological and pathological processes. What is more, miR-155 can be used as a potential therapeutic target for inflammatory diseases. We analyze the articles about miR-155 for nearly five years, review the advanced study on the function of miR-155 in different inflammatory cells like T cells, B cells, DCs, and macrophages, and then summarize the biological functions of miR-155 in different inflammatory cells. The widespread involvement of miR-155 in human diseases has led to a novel therapeutic approach between Chinese and Western medicine.

Differential Expression Profile of Salivary oncomiRNAs among Smokeless Tobacco Users

“…39 In addition, Hu et al demonstrated that miR-155 overexpression regulates many cancer-related pathways involving cell proliferation, invasion, migration, stemness, and angiogenesis. 40 This agrees with the current findings that miR-155 was overexpressed in all the SLT users enrolled in the study in comparison with the nonsmokers. Likewise, in agreement with the literature, miR-21 was found to be overexpressed in 40% of SLT users in this study.…”

Proposal of a bioinformatics approach to predict molecular mechanisms involved in inflammatory response: case of ATRA and 1,25(OH) 2 D in adipocytes

“…In the present study, we also reported an induction of miR-155 under inflammatory stimulation. Such induction is fully consistent with the literature where it has been described that miR-155 expression has been associated with inflammatory response and diseases [ 46 ]. Furthermore, in a previous study, we have demonstrated that miR-155 is induced in murine and human adipocytes in inflammatory conditions through TNFα, via an NF-kB-dependent mechanism [ 33 ].…”

Expression and Biological Functions of miRNAs in Chronic Pain: A Review on Human Studies

“…Its expression is induced by factors associated with infections, injury, hypoxia and inflammation, through signaling pathways involving NF-κB activation; contrarily, it is decreased by anti-inflammatory cytokines, resolvins and glucocorticoids, thus providing a feedback inhibition of the miR-155-induced responses [ 108 ]. MiR-155-5p plays a multifunctional role in innate and adaptive immunity and inflammation, so that its aberrant overexpression represents a potential disease biomarker or therapeutic target in states of chronic inflammation [ 109 ]. Its involvement in neuroinflammation, vascular dysfunction and neurodegeneration has been documented in animal and human studies [ 110 , 111 ].…”