Proliferation Activity and Number of Stromal (CFU-f) and Haemopoietic (CFUs) Stem Cells in Bone Marrow and Spleen of Rats of Different Ages

Abstract

Vacek A.: Proliferation Activity

Restoration of femoral GM-CFC progenitors in sublethally irradiated mice of various ages treated with liposomal adamantylamide dipeptide

“…Both L-AdDP and AdDP preparations were not able to stimulate hemopoiesis in young mice whose pool of hemopoietic stem cells was drastically reduced by relatively high doses of girradiation hence the spontaneous recovery was a long lasting event. The large numbers of surviving stromal cells in adult and old animals increase their proliferation activity during the recovery after sublethal girradiation and can produce also cytokines supporting the recovery of the radiation-damaged hemopoiesis in bone marrow [19]. On the other hand, higher radiation doses should be used in old mice which are more resistant towards g-irradiation and whose pool of hemopoietic stem cells remained relatively high after g-irradiation.…”