Prolidase-dependent regulation of collagen biosynthesis

Surażyński, Arkadiusz; Miltyk, Wojciech; Pałka, Jerzy; Phang, James M.

doi:10.1007/s00726-008-0051-8

Cited by 140 publications

(161 citation statements)

References 62 publications

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“…Prolidase activity has been shown in dermal fibroblasts [28]. The enzyme activity plays an important role in the recycling of proline mostly derived from degradation products of collagen [29]. Wei et al [30] have been reported that glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism.…”

Section: Discussionmentioning

confidence: 99%

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Doğan¹,

Hayta²

2017

Med-Science

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Dermatophyte infections are superficial fungal infections. Tinea pedis is a dermatophyte infection of the feet and interdigital spaces. An evaluation was made of the chitotriosidase (ChT) concentrations, prolidase activity and the possible association between these biomarkers in tinea pedis. Study subjects were comprised of 42 patients with tinea pedis and 40 healthy subjects. Serum ChT concentrations and prolidase activity were determined in study population. Higher ChT concentrations were found in patients than controls (p < 0.001). We did not find any difference between groups in terms of prolidase activity (p = 0.162). We also did not found any correlation between ChT and prolidase activity. ChT seems to have roles during the inflammatory conditions in patients with tinea pedis. Whereas prolidase activity is not associated with the tinea pedis.

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Section: Discussionmentioning

confidence: 99%

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Doğan¹,

Hayta²

2017

Med-Science

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“…Although extracellular collagenases initiate the breakdown of collagen, the final step of collagen degradation is catalyzed by intracellular prolidase. Moreover, it has been suggested that prolidase activity may be a rate-limiting factor in the regulation of collagen biosynthesis [7] . Collagen is the major component of the extracellular matrix (ECM), which represents a major barrier against invasion by neoplastic cells.…”

Section: Discussionmentioning

confidence: 99%

“…Deregulation of tissue collagen metabolism is one of the consequences of neoplastic transformation. Metalloproteinases initiate the breakdown of collagen; however, the final step of collagen degradation is mediated by prolidase [6,7] .Prolidase is an important enzyme that cleaves the bonds of dipeptides containing proline (X-Pro), and plays a vital role in collagen turnover, matrix remodeling and cell growth. Metastatic tumor cells produce enhanced amounts of proteases that enable them to penetrate basement membranes and the extracellular matrix (ECM) [8] .…”

Section: Introductionmentioning

confidence: 99%

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

İlikhan¹,

Bilici²,

Şahin³

et al. 2015

WJG

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AIM:To determine the predictive value of increased prolidase activity that reflects increased collagen turnover in patients with hepatocellular carcinoma (HCC). METHODS:Sixty-eight patients with HCC (mean age of 69.1 ± 10.1), 31 cirrhosis patients (mean age of 59.3 ± 6.3) and 33 healthy volunteers (mean age of 51.4 ± 12.6) were enrolled in this study. Univariate and multivariate analysis were used to evaluate the association of serum α-fetoprotein (AFP) values with HCC clinicopathological features, such as tumor size, number and presence of vascular and macrovascular invasion. The patients with HCC were divided into groups according to tumor size, number and presence of vascular invasion (diameters; ≤ 3 cm, 3-5 cm Prospective Study ORIGINAL ARTICLEand ≥ 5 cm, number; 1, 2 and ≥ 3, macrovascular invasion; yes/no). Barcelona-clinic liver cancer (BCLC) criteria were used to stage HCC patients. Serum samples for measurement of prolidase and alphafetoprotein levels were kept at -80 ℃ until use. Prolidase levels were measured spectrophotometrically and AFP concentrations were determined by a chemiluminescence immunometric commercial diagnostic assay. RESULTS:In patients with HCC, prolidase and AFP values were evaluated according to tumor size, number, presence of macrovascular invasion and BCLC staging classification. Prolidase values were significantly higher in patients with HCC compared with controls (P < 0.001). Prolidase levels were significantly associated with tumor size and number (P < 0.001, P = 0.002, respectively). Prolidase levels also differed in patients in terms of BCLC staging classification (P < 0.001). Furthermore the prolidase levels in HCC patients showed a significant difference compared with patients with cirrhosis (P < 0.001). In HCC patients grouped according to tumor size, number and BCLC staging classification, AFP values differed separately (P = 0.032, P = 0.038, P = 0.015, respectively). In patients with HCC, there was a significant correlation (r = 0.616; P < 0.001) between prolidase and AFP values in terms of tumor size, number and BCLC staging classification, whereas the presence of macrovascular invasion did not show a positive association with serum prolidase and AFP levels. CONCLUSION:Considering the levels of both serum prolidase and AFP could contribute to the early diagnosing of hepatocellular carcinoma. Core tip: Prolidase cleaves dipeptide bonds containing proline, playing a vital role in collagen turnover, matrix remodeling and cell growth. Neoplastic transformation results in deregulation of tissue collagen metabolism, in which metastatic tumor cells produce enhanced amounts of proteases to penetrate basement membranes and the extracellular matrix. Therefore, tumor progression might depend on the breakdown of collagen and other extracellular matrix proteins. The role of prolidase in neoplastic tissues is unknown. Herein, serum prolidase levels in hepatocellular carcinoma (HCC) patients were significantly associated with tumor size and number, Barcelona-clinic liver can...

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“…Glycyl-proline is the best substrate for the prolidase (1). It is a manganese requiring homodimeric enzyme (subunit M r ≈ 54.3KDa ).…”

Section: Introductionmentioning

confidence: 99%

“…It is a cytosolic enzyme and it was purifi ed from several sources, including human erythrocytes, fi broblasts and different strains of bacteria (1).The enzyme activity is relatively high in kidneys, intestinal mucosa and erythrocytes, while it is low in plasma and liver. The plasma prolidase activity is about 6 % as great as in erythrocytes enzyme activity (3).…”

Section: Introductionmentioning

confidence: 99%

Prolidase

Namiduru¹

2016

BLL

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Prolidase (EC.3.4.13.9) or proline dipeptidase, is one of the unique enzyme capable of degrading dipeptides, in which a proline or hydroxyproline residue is located at the C-terminal position. Prolidase has a unique function in all cell types; therefore, the mechanisms and parameters involved in prolidase activity regulation are of special interest. Could prolidase be a good biomarker in different physiologic and pathologic conditions? This is an important question. There is no consensus on the answer to this question. It is of great importance during collagen turnover, infl ammation, tissue fi brosis and skeletal abnormalities. Prolidase itself without other biochemical markers may not provide information to clinicians about disease activity. So, I think it should be evaluated together with other serum biochemical markers. This review will serve to discuss many in vivo functions of prolidase, as well as level prolidase activity in diagnosis and monitoring of treatment in the various diseases (Ref. 50). Text in PDF www.elis.sk.

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Prolidase-dependent regulation of collagen biosynthesis

Cited by 140 publications

References 62 publications

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Chitotirosidase and prolidase in tinea pedis: A preliminary study

Assessment of the correlation between serum prolidase and alpha-fetoprotein levels in patients with hepatocellular carcinoma

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