Prolactin secretion in 70 patients with growth hormone deficiency

Roitman, A.; Assa, S.; Pertzelan, A; Zadik, Zvi; Laron, Zvi

doi:10.1007/bf00496085

Cited by 10 publications

(4 citation statements)

References 28 publications

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“…It is reported that patients with hypothalamic lesions and IGHD often, but not invariably (Snyder et al 1974;Roitman et al 1980), show delayed and prolonged TSH responses to TRH (Hall et al 1972; Kaplan et al 1972;Faglia et al 1973;Illig et al 1975;Burger and Patel 1977;Okada et al 1978 ;Gamier et al 1983). In this study, all IGHD patients were of euthyroid state, but they showed delayed TSH responses to TRH as was seen also in 2ry GHD patients.…”

Section: Discussionsupporting

confidence: 60%

GHRH and TRH tests in patients with idiopathic and secondary GH deficiency. With special reference to GH response patterns to GHRH.

Hanew

Sugawara

Utsumi

et al. 1990

Tohoku J. Exp. Med.

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Tests in Patients with Idiopathic and Secondary GH Deficiency -With Special Reference to OH Response Patterns to GHRH . Tohoku J. Exp. Med., 1990, 160 (3), [189][190][191][192][193][194][195][196][197][198][199][200][201][202] To study whether patients with idiopathic GH deficiency (IGHD) show a delayed GH response pattern to GHRH, 42 patients with IGHD, 14 patients with hypothalamic tumor (try GHD), and 23 normal short children (NSC) were examined as to their GH response patterns to GHRH together with their TSH and PRL response patterns to TRH. After TRH injection, the mean time of the TSH peak in IGHD (67.5 + 6.5 min, n = 36) and try GHD patients (81.7± 14.8 min, n = 9) was clearly delayed comparing to that of NSC (29.1 + 2.9 min, n =16 ; both p <0.01). Similarly, the mean time of the PRL peak in IGHD (38.3 + 3.6 min, n = 36) and try GHD patients (39.5 + 5.8, n =11) was significantly delayed comparing to NSC (22.0+3.5 min, both p <0.01). In IGHD patients, the delayed response pattern of TSH and PRL was more remarkable in patients who had breech delivery than in those with normal delivery. In contrast, the mean time of the GH peak was similar in I GHD (62.1±4.0 min, n =41), try GHD (64.1± 8.1 min, n =11) and NSC (58.0± 6.1 min, n =23). However, the decline from peak GH (120 min GH/peak GH) was significantly smaller in IGHD (54.3+ 4.2%) and try GHD (60.7+7.3%) than in NSC (39.0+8.1%) (both p<0.05). Further, in IGHD patients plasma GH response was greater in patients with normal delivery than in those with breech and asphyxia delivery. These results seem to indicate : 1) the stimulus-secretion mechanism is different between somatotrophs and thyrotrophs or lactotrophs in man, 2) IGHD patients have hypothalamic lesions as well as pituitary lesions, 3) such hypothalamo-pituitary lesions in IGHD patients are greater in patients with abnormal delivery than in those with normal delivery, idiopathic GH deficiency ; GHRH ; TRH ; GII ; TSH It is known that patients with hypothalamic lesions and idiopathic growth hormone deficiency (IGHD) often show delayed TSH responses to TRH adminis-

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Section: Discussionsupporting

confidence: 60%

GHRH and TRH tests in patients with idiopathic and secondary GH deficiency. With special reference to GH response patterns to GHRH.

Hanew

Sugawara

Utsumi

et al. 1990

Tohoku J. Exp. Med.

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“…There is, however, relatively little information on the PRL response to TRH in children (Foley et al 1972;Kaplan et al 1972;Okada et al 1978 ;Suter et al 1978 ;Roitman et al 1980;Abe et al 1982Abe et al , 1983). Since it has been known that PRL plays some role for breast development (Frantz 1981) …”

mentioning

confidence: 99%

Prolactin response to thyrotropin-releasing hormone in children with gynecomastia, premature thelarche and idiopathic precocious puberty.

Abe

Matsuura

Nohara

et al. 1984

Tohoku J. Exp. Med.

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“…However, the information on PRL response to arginine is scarce in children [2,4]. Since growth hormone (GH) deficiency is often associated with PRL deficiency [8] and arginine infusion permits the simultaneous determination of GH response which has its own diagnostic value, we thought it of interest to explore the characteristics of PRL release following arginine infusion in children. The present study shows that in children without GH deficiency arginine infusion over a 30-min period elicited a significant rise in plasma PRL and its elevation was greater in pubertal than in prepubertal children in both sexes.…”

Section: Discussionmentioning

confidence: 99%

“…The determination of PRL levels and its response to provocative stimuli has been described to be useful for investigating hypothalmo-pituitary function [5,8,9]. Among provocative stimuli, thyrotropin releasing hormone (TRH) is most often used as a potent stimulus for PRL secretion.…”

Section: Discussionmentioning

confidence: 99%

Prolactin response to arginine in children with hyperthyroidism and primary hypothyroidism

et al. 1982

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Plasma prolactin (PRL) response to arginine was examined in 16 prepubertal and 18 pubertal children with constitutional short stature, 5 patients with hyperthyroidism and 4 patients with primary hypothyroidism. The mean basal concentration of plasma PRL was significantly higher (P less than 0.01) in primary hypothyroidism than in other groups. Arginine infusion elicited significant (P less than 0.05) rises in plasma PRL in all groups. The maximal increment of plasma PRL above the baseline level after arginine stimulation was significantly larger (P less than 0.05) in pubertal than in prepubertal females and was significantly smaller (P less than 0.05) in patients with hyperthyroidism than in age- and sex-matched controls. There was no sex difference in arginine-stimulated PRL secretion. These data suggest that arginine produces a significant increase in plasma PRL and the PRL response to arginine was greater in pubertal than in prepubertal children. Plasma PRL response to arginine is suppressed in children with hyperthyroidism and the basal plasma PRL is markedly elevated in primary hypothyroidism.

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Prolactin secretion in 70 patients with growth hormone deficiency

Cited by 10 publications

References 28 publications

GHRH and TRH tests in patients with idiopathic and secondary GH deficiency. With special reference to GH response patterns to GHRH.

GHRH and TRH tests in patients with idiopathic and secondary GH deficiency. With special reference to GH response patterns to GHRH.

Prolactin response to thyrotropin-releasing hormone in children with gynecomastia, premature thelarche and idiopathic precocious puberty.

Prolactin response to arginine in children with hyperthyroidism and primary hypothyroidism

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