Prolactin-Secreting Pituitary Microadenomas

Vezina, J L; Sutton, Tudor J.

doi:10.2214/ajr.120.1.46

Cited by 149 publications

(21 citation statements)

References 9 publications

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“…Hyperprolactinaemia occurs in some men with functionless pituitary tumours (Thorner et al, 1974), but again its frequency has not been determined. Vezina and Sutton (1974) found that all 20 of their patients with hyperprolactinaemia and associated amenorrhoea and galactorrhoea had radiological evidence of a pituitary tumour after careful tomography, even though a plain x-ray examination of the pituitary.fossa showed it to be of normal size in 14 patients. All their patients subsequently had transphenoidal surgery, and pituitary tumours were found in each case.…”

Section: Introductionmentioning

confidence: 97%

Prolactin Studies in “Functionless” Pituitary Tumours

Child

Nader-Eftekhari

Mashiter

et al. 1975

Obstetrical & Gynecological Survey

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Section: Introductionmentioning

confidence: 97%

Prolactin Studies in “Functionless” Pituitary Tumours

Child

Nader-Eftekhari

Mashiter

et al. 1975

Obstetrical & Gynecological Survey

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“…How¬ ever, Glass et al (1976) detected only 3 pituitary tumours in their 13 hyper¬ prolactinaemic women but these were examined with lateral skull X-rays only, a possible explanation for the low incidence. This stresses the need of both antero-posterior and lateral X-ray projections of the sella turcica in women with amenorrhoea and several investigators also recommend routine tomo¬ graphy of the pituitary fossa of all women with hyperprolactinaemia (Vezina 8c Sutton 1974;Jacobs et al 1975;Nader et al 1976). …”

Section: Discussionmentioning

confidence: 99%

Hyperprolactinaemia in Amenorrhoea - Incidence and Clinical Significance

Bergh

Nillius

Wide

1977

Acta Endocrinologica

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Prolactin concentrations in serum were determined in 287 women with amenorrhoea. The incidence of hyperprolactinaemia was 14.6 per cent. All but 4 of the 31 women with persistent hyperprolactinaemia had galactorrhoea. Radiological signs suggestive of a pituitary tumour were seen in 48 per cent of the hyperprolactinaemic women, while only 4.5 per cent of the 245 normoprolactinaemic women had abnormal sellar X-rays. All the patients with prolactin concentrations above 100 \g=m\g/I had radio\x=req-\ logically abnormal sellae, but lower prolactin levels did not rule out the existence of even large pituitary tumours. The hyperprolactinaemic women with normal and abnormal sellae and a control group of healthy women in the early follicular phase all had similar mean basal FSH and LH levels with one exception, the group with abnormal sellae had lower basal LH levels than the control group. There was no difference in the mean FSH and LH responses to LH-RH between the hyperprolactinaemic women with pathological sellae and the control group while the hyperprolactinaemic women with normal sellae had higher responses than the other two groups. Prolactin determinations were found to be superior to other pituitary hormone estimations for identifying patients who are at risk of having pituitary tumours.The isolation of human prolactin (Hwang et al. 1972;Lewis et al. 1972) and the development of a radioimmunoassay for this hormone (Hwang et al. 1971) have provided the clinician with means of studying the role of prolactin in

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“…Others elsewhere were unable to find these field defects and attributed most of the field defects as functional." There is strong suspicion that most of the patients with the galactorrhea-amenorrhea syndrome have adenomata-of the pituitary gland (9,10). From the reports on the course of pregnancies induced in women with the galactorrhea-amenorrhea syndrome with or without sellar enlargement but without visual complications at tlie onset of pregnancy, visual or other pituitary complications during pregnancy only occurred in patients whose pituitary had not been pretreated by irradiation (11)(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Transient Bitemporal Hemianopsia During Pregnancy After Treatment of Galactorrhea-Amenorrhea Syndrome with Bromocriptine

Lamberts

Seldenrath

Kwa

et al. 1977

The Journal of Clinical Endocrinology & Metabolism

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A patient is described with a galactorrhea-amenorrhea syndrome and an enlargement of the sella turcica. Pregnancy occurred after induction of ovulation with bromocriptine (and 2.5 years after pituitary irradiation). Periodic assessment of the visual fields showed an increase in size of the blind spots after 10 weeks and a moderate bitemporal hemianopsia after 22 weeks, which improved spontaneously after 30 weeks of pregnancy. One month after delivery the visual field of the left eye was almost normalized, while that of the right eye showed a definite improvement. Prior radiotherapy need not prevent visual complications from enlargement of pituitary adenomas during pregnancy.

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Prolactin-Secreting Pituitary Microadenomas

Cited by 149 publications

References 9 publications

Prolactin Studies in “Functionless” Pituitary Tumours

Prolactin Studies in “Functionless” Pituitary Tumours

Hyperprolactinaemia in Amenorrhoea - Incidence and Clinical Significance

Transient Bitemporal Hemianopsia During Pregnancy After Treatment of Galactorrhea-Amenorrhea Syndrome with Bromocriptine

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