Transient Bitemporal Hemianopsia During Pregnancy After Treatment of Galactorrhea-Amenorrhea Syndrome with Bromocriptine

Lamberts, S. W. J.; Seldenrath, H. J.; Kwa, H. G.; Birkenhaäger, J. C.

doi:10.1210/jcem-44-1-180

Cited by 44 publications

(6 citation statements)

References 12 publications

(10 reference statements)

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“…Breast feeding was successful in most of our patients who attempted it and this confirms the findings of Bergh et a1 (1978) in patients with prolactinomas, and contrasts with the report by Mornex et a1 (1978) of insufficiency of milk production in all their seven hyperprolactinaemic patients who attempted breast feeding. Isolated instances of tumour expansion during pregnancy in patients with hyperprolactinaemia exist (Corbey et al, 1977;Jewelewicz et al, 1977;Lamberts et al, 1977), but the overall incidence is uncertain. Isolated instances of tumour expansion during pregnancy in patients with hyperprolactinaemia exist (Corbey et al, 1977;Jewelewicz et al, 1977;Lamberts et al, 1977), but the overall incidence is uncertain.…”

Section: Discussionmentioning

confidence: 99%

“…The normal pituitary gland increases in size in pregnancy (Erdheim and Stumme, 1909); with prolactinomas there is a special risk of rapid and extensive tumour expansion during pregnancy with severe headaches, diabetes insipidus and optic nerve compression with visual field defects and diminished visual acuity (Kajtar and Tomkin, 1971;Swyer et al, 1971;Burke et al, 1972;Gemzell, 1975;Lamberts et al, 1977;Corbey et al, 1977;Bergh et al, 1978;Nagulesparen and Roper, 1978). The normal pituitary gland increases in size in pregnancy (Erdheim and Stumme, 1909); with prolactinomas there is a special risk of rapid and extensive tumour expansion during pregnancy with severe headaches, diabetes insipidus and optic nerve compression with visual field defects and diminished visual acuity (Kajtar and Tomkin, 1971;Swyer et al, 1971;Burke et al, 1972;Gemzell, 1975;Lamberts et al, 1977;Corbey et al, 1977;Bergh et al, 1978;Nagulesparen and Roper, 1978).…”

Section: Ovulation (Del Pozo Et A/mentioning

confidence: 99%

See 1 more Smart Citation

Pregnancies in Women With Hyperprolactinaemia: Clinical Course and Obstetric Complications of 41 Pregnancies in 27 Women

Kelly

Doyle

Mashiter

et al. 1979

BJOG

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Summary Observations are reported on 41 pregnancies in 27 patients who initially had infertility and raised serum prolactin concentrations. Associated symptoms were secondary amenorrhoea (81 per cent) and galactorrhoea (81 per cent). All patients were at risk of pituitary expansion during pregnancy, especially these 19 (70 per cent) with radiological evidence of pituitary tumours. Fifteen patients had 21 pregnancies after pituitary implantation with 90yttrium; 14 patients had 20 pregnancies without prior pituitary implantation or any other attempt to prevent tumour expansion. During pregnancies, tumour enlargement as shown by diminished visual acuity, visual field defects, severe headaches, diabetes insipidus and radiological changes occurred only in 3 of the 14 patients who had not had implants. Two patients who became pregnant both before and after pituitary implantation suffered tumour expansion in their pregnancies before implantation, but not when pregnant after the operation. The induction and Caesarean section rates were about 30 per cent in 32 term pregnancies in 25 patients. Details of how pregnancy was achieved and the associated obstetric problems are given.

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Section: Discussionmentioning

confidence: 99%

Section: Ovulation (Del Pozo Et A/mentioning

confidence: 99%

Pregnancies in Women With Hyperprolactinaemia: Clinical Course and Obstetric Complications of 41 Pregnancies in 27 Women

Kelly

Doyle

Mashiter

et al. 1979

BJOG

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“…After delivery, the gland rapidly involutes and returns to its normal size by 6 months postpartum (358,359). Reports of enlargement of prolactinomas associated with pregnancy began over 30 yr ago, shortly after the introduction of bromocriptine as an effective medical therapy for these tumors (334,(361)(362)(363)(364)(365)(366)(367)(368)(369). Early on, many of the symptomatic patients underwent surgery for visual defects (334,363,365,367).…”

Section: A Effect Of Pregnancy On Prolactinoma Growthmentioning

confidence: 99%

“…Early on, many of the symptomatic patients underwent surgery for visual defects (334,363,365,367). However, the observation was soon made that in those who were managed without surgery, symptoms resolved shortly after parturition (334,364,366,368). The enlargement of macroadenomas during pregnancy is therefore due to two factors: 1) discontinuation of the dopamine agonist that had caused the tumor to shrink; and 2) the stimulatory effect of the high estrogen levels produced by the placenta.…”

Section: A Effect Of Pregnancy On Prolactinoma Growthmentioning

confidence: 99%

Advances in the Treatment of Prolactinomas

et al. 2006

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Prolactinomas account for approximately 40% of all pituitary adenomas and are an important cause of hypogonadism and infertility. The ultimate goal of therapy for prolactinomas is restoration or achievement of eugonadism through the normalization of hyperprolactinemia and control of tumor mass. Medical therapy with dopamine agonists is highly effective in the majority of cases and represents the mainstay of therapy. Recent data indicating successful withdrawal of these agents in a subset of patients challenge the previously held concept that medical therapy is a lifelong requirement. Complicated situations, such as those encountered in resistance to dopamine agonists, pregnancy, and giant or malignant prolactinomas, may require multimodal therapy involving surgery, radiotherapy, or both. Progress in elucidating the mechanisms underlying the pathogenesis of prolactinomas may enable future development of novel molecular therapies for treatment-resistant cases. This review provides a critical analysis of the efficacy and safety of the various modes of therapy available for the treatment of patients with prolactinomas with an emphasis on challenging situations, a discussion of the data regarding withdrawal of medical therapy, and a foreshadowing of novel approaches to therapy that may become available in the future.

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“…The central scotoma can be misinterpreted as a result of optic neuritis. The association of optic neuritis and pregnancv has previously been suggested.47 Visual disturbances during pregnancy have been reported as a result of the expansion of intracranial tumours (meningiomas, pituitary adenomas, and craniopharyngiomas) owing to hormonal changes.5 [8][9][10][11] As in our patients with central serous choroidopathy the spontaneous recovery of visual functions after delivery has been described in patients with intracranial tumrours.9 '2 If central serous choroidopathv is the cause of visual disturbances during pregnancv. its correct diagnosis mav avert superfluous diagnostic and therapeutic measures.…”

Section: Discussionmentioning

confidence: 99%