Prolactin attenuates global cerebral ischemic injury in rat model by conferring neuroprotection

Vermani, Bhawna; Mukherjee, Sumedha; Kumar, Gaurav; Patnaik, Ranjana

doi:10.1080/02699052.2020.1726466

Cited by 14 publications

(5 citation statements)

References 40 publications

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“…Glutamate toxicity led to excess Na + and Ca 2+ in ux into neuronal cells which was critical mechanism of neuronal death in IS [33]. The study proved that prolactin was involved in hypothalamic neuronal signaling through regulating the MAPK/ERK pathway, and was a potential candidate for neurotherapeutics as it signi cantly reduced brain calcium and nitrate levels in different brain regions of MCAO rats to improve cerebral ischemia-reperfusion injury [34,35]. Lin et al [36] found that quercetin might promote prolactin receptor (PRLR) expression through the activation of AKT which contributed to axon regeneration.…”

Section: Discussionmentioning

confidence: 88%

Exploring the Potential Mechanism of Zhengan Xifeng Decoction for ischemic stroke based on Network pharmacology and Molecular Docking

Feng

Zhang

Liu

et al. 2022

Preprint

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Backgroud Ischemic stroke (IS) is an acute cerebrovascular incident that threatens public health. Zhengan Xifeng Decoction (ZXD), as a common herbal formula, has been widely applied in clinical practice for IS. The purpose of this study was to investigate the bioactive ingredients and potential pharmacological mechanisms of ZXD for IS based on network pharmacology and molecular docking.Methods Chemical ingredients of ZXD were screened from TCMSP, BATMAN-TCM and the literature. Then, the targets of the chemical ingredients were predicted through STITCH and SwissTargetPrediction databases. IS-related targets were selected from DisGeNET, DrugBank, MalaCards and GeneCards databases. And, the String database and Cytoscape 3.8.2 software were used to construct the protein-protein interaction (PPI) network. Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analysis were analyzed in Metascape. At last, Molecular docking was carried out using Open Babel GUI, AutoDock 1.5.6 and Pymol.Results 284 active ingredients involving 2353 putative targets were identified in ZXD, of which 1098 targets were linked to IS. A total of 20 core targets including MAPK3, MAPK1, and AKT1 were identified by analyzing PPI network. The biological process associated with IS were related to response to growth factor, apoptotic signaling pathway, MAPK cascade and neuron death. And KEGG enrichment included that Prolactin signaling pathway, VEGF signaling pathway and ErbB signaling pathway were closely correlated with neurogenesis, neurotransmission, synaptic plasticity vascular growth factor regulation, in IS. Finally, molecular docking revealed that core ingredients of Quercetin, Carvone and Asparamide had well-binding ability to core targets.Conclusion The study suggested that ZXD treated IS by modulating multiple targets and pathways. And, the results demonstrated that the mechanism of ZXD anti-IS may be related to the regulation of neuroprotection and angiogenesis through Prolactin signaling pathway, VEGF signaling pathway and the ErbB signaling pathway.

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Section: Discussionmentioning

confidence: 88%

Exploring the Potential Mechanism of Zhengan Xifeng Decoction for ischemic stroke based on Network pharmacology and Molecular Docking

Feng

Zhang

Liu

et al. 2022

Preprint

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“…Interestingly, a similar protective function was noted after high-dose PRL was administered in rats in global cerebral ischemia induced by bilateral common carotid occlusion. PRL decreased cerebral infarction volume and edema associated with a significant reduction in neurotransmitters, particularly, gamma-aminobutyric acid, Glu, and calcium concentrations [118]. These observations suggest that PRL may Neuroprotection Mediated by Prolactin during Excitotoxicity: New Functions and Insights DOI: http://dx.doi.org/10.5772/intechopen.113798 restore both physiological and biochemical parameters in the damaged brain tissue.…”

Section: The Role Of Prolactin In Neuroprotection In the Hippocampusmentioning

confidence: 83%

Neuroprotection Mediated by Prolactin during Excitotoxicity: New Functions and Insights

Molina-Salinas,

Rodríguez-Chávez,

Cerbón

2024

Drug Development and Safety

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Prolactin (PRL) is a peptide and pleiotropic hormone with more than 300 associated functions such as maternal behavior, lactation, osmoregulation, angiogenesis, and the immune system. It is associated with several functions in the brain, including lactation, cognition and memory, maternal behavior, and neurogenesis. PRL reportedly plays an important role in neuroprotection against excitotoxicity caused by glutamate (Glu) and kainic acid (KA) damage in vitro and in vivo models. However, the molecular mechanisms involved in the neuroprotective effects of PRL are unclear. Despite this, data suggest the involvement of PI3K/AKT, and GSK3β/NF-κB signaling pathways, which are involved in neuroprotection. In addition, PRL inhibits Glu- and KA-induced increase by intracellular Ca2+ concentration, leading to neuronal survival. We also discuss current knowledge on the role of PRL in neurodegenerative diseases. New avenues of research into the protective mechanisms of PRL and its potential therapeutic effects on the brain under pathological and physiological conditions are needed.

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“…PRL mainly exerts neuroprotective effects by inhibiting excitatory toxicity ( 124 , 125 ) and neuroinflammation ( 126 , 127 ). In the cerebral ischemia model, PRL reduced the cerebral infarction area and cerebral water content and restored the physiological status ( 128 ). Transient ischemic attack increased PRL concentrations and increased plasma PRL levels were significantly linked with platelet P-selectin ( 129 , 130 ).…”

Section: Sex Hormones and Ischemic Strokementioning

confidence: 99%

Research progress on the role of hormones in ischemic stroke

Huang

Liu²,

Tang³

et al. 2022

Front. Immunol.

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Ischemic stroke is a major cause of death and disability around the world. However, ischemic stroke treatment is currently limited, with a narrow therapeutic window and unsatisfactory post-treatment outcomes. Therefore, it is critical to investigate the pathophysiological mechanisms following ischemic stroke brain injury. Changes in the immunometabolism and endocrine system after ischemic stroke are important in understanding the pathophysiological mechanisms of cerebral ischemic injury. Hormones are biologically active substances produced by endocrine glands or endocrine cells that play an important role in the organism’s growth, development, metabolism, reproduction, and aging. Hormone research in ischemic stroke has made very promising progress. Hormone levels fluctuate during an ischemic stroke. Hormones regulate neuronal plasticity, promote neurotrophic factor formation, reduce cell death, apoptosis, inflammation, excitotoxicity, oxidative and nitrative stress, and brain edema in ischemic stroke. In recent years, many studies have been done on the role of thyroid hormone, growth hormone, testosterone, prolactin, oxytocin, glucocorticoid, parathyroid hormone, and dopamine in ischemic stroke, but comprehensive reviews are scarce. This review focuses on the role of hormones in the pathophysiology of ischemic stroke and discusses the mechanisms involved, intending to provide a reference value for ischemic stroke treatment and prevention.

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Prolactin attenuates global cerebral ischemic injury in rat model by conferring neuroprotection

Cited by 14 publications

References 40 publications

Exploring the Potential Mechanism of Zhengan Xifeng Decoction for ischemic stroke based on Network pharmacology and Molecular Docking

Exploring the Potential Mechanism of Zhengan Xifeng Decoction for ischemic stroke based on Network pharmacology and Molecular Docking

Neuroprotection Mediated by Prolactin during Excitotoxicity: New Functions and Insights

Research progress on the role of hormones in ischemic stroke

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