Projections of the Parabrachial Nucleus in the Old World Monkey

Pritchard, Thomas C.; Hamilton, Robert; Norgren, Ralph

doi:10.1006/exnr.2000.7450

Cited by 113 publications

(90 citation statements)

References 118 publications

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“…This result, together with the topographic gradient in the projection to the striatum, suggests a complicated organization within Pf. Although the presence of visceral input to Pf had been suggested by anatomical observations of afferent input from the solitary nucleus in rats (Ruggiero et al, 1998) and from the parabrachial nucleus in rats (Saper and Loewy, 1980;Cornwall and Phillipson, 1988;Krout and Loewy, 2000) and monkeys (Prichard et al, 2000), none of these studies suggested segregation of this input within Pf.…”

Section: Organization Of Sensory Input To Pfmentioning

confidence: 97%

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Ito

Craig

2007

J of Comparative Neurology

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We recently reported that the thalamic parafascicular nucleus (Pf) in monkeys is strongly activated by vagus nerve afferents. The main forebrain target of Pf is the striatum, but the specific striatal regions receiving visceral input via this pathway are unknown. We examined the projections of this region by injecting anterograde tracers into the vagus evoked potential (VEP) focus in Pf of macaque monkeys. The VEP was strongest lateral and anterior to the habenulointerpeduncular tract, but it was distributed across the entire horizontal extent of the ventral half of Pf. All injections produced labeled terminals in the caudate (Cd), especially the Cd tail and the adjacent ventral posterior Pu. Terminations occurred throughout the Cd head and body but spared the most anterior and dorsolateral parts. Injections in more anterior and lateral portions of Pf produced progressively more terminations in Pu, mainly in the precommissural region and the medial aspect of posterior Pu. Dual injections of different tracers revealed overlapping projections with interdigitated strands of striatal terminations from separate regions of Pf as well as the posteromedial to anterolateral topographic gradient of increasing Pf projections to Pu. An injection in the most anteromedial portion of Pf produced strong labeling in the ventral striatum. Thus, Pf transmits viscerosensory information to the "associative" and "limbic" territories of the striatum. These findings suggest the broad involvement of homeostatic afferent activity in striatal function and perhaps a role for the striatum in autonomic function.

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Section: Organization Of Sensory Input To Pfmentioning

confidence: 97%

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Ito

Craig

2007

J of Comparative Neurology

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“…3), the visceral region in the caudal part of the NTS projects to the PBN. The PBN projects to the rostral half of the VPMpc (the non-taste part), the CEA, the lateral hypothalamic nuclei, the VTA, and to the SN in macaques [52,57,62,63]. The visceral part of VPMpc projects to the agranular insula which is located just posterior to the OFC [64,65] and the insula projects to the ventral striatum (VS) [66].…”

Section: Pathways Of Oral and Visceral Information Neural Pathwaysmentioning

confidence: 99%

“…The CEA receives visceral information directly from the PBN [52,57,62,63,125,126] and gustatory information from the posterior OFC [56,127] while the lateral nucleus of the amygdala (BLA) receives gustatory information from the IC [128,129]. There are some connections between the CEA and BLA [130].…”

Section: Amygdalamentioning

confidence: 99%

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Beyond flavour to the gut and back

Kadohisa

2015

Flavour

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This paper describes how food is sensed in both the mouth where it produces food reward and pleasantness that guides food intake and is sensed in the gut where it produces satiety and conditioned effects including learned appetite and learned satiety for the food eaten. Taste and other receptors present in both the mouth and gut are involved in these effects. The signals about the presence of food in the mouth and gut are transferred by separate pathways to the brain where the satiety signals from the gut reduce the reward value and subjective pleasantness of taste and other oral sensory signals including food texture. Food flavour preferences can be associatively conditioned by pairing with food in the gut in brain regions such as the orbitofrontal cortex and amygdala. Current issues considered in this paper are how gut sensing of food influences hormone release including cholecystokinin (CCK), peptide YY (PYY), and glucagon-like peptide-1 (GLP-1); how the sensing of different nutrients in the gut may influence unconditioned satiety and conditioned preference and satiety; and how cognition may modulate the pleasantness of food and thus the control of food intake.

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“…The nucleus tractus solitarius (NTS) in the medulla receives taste information from peripheral taste nerves and sends gustatory information to the pontine parabrachial nucleus (PBN). Gustatory neurons in the PBN pass through two parallel ascending paths, one path goes to thalamocortical axis and the other directly goes to the amygdala [23] . Gustatory and visceral information from the PBN may travel through the insular cortex or the thalamus, ultimately reaching the BLA.…”

Section: Bla and Ctamentioning

confidence: 99%

Leptin receptor expression in the basolateral nucleus of amygdala of conditioned taste aversion rats

Han

Yan²,

Luo³

et al. 2003

WJG

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AIM: To determine whether serum leptin level and the leptin receptor (OB-R) expression in the basolateral amygdala (BLA) change following conditioned taste aversion (CTA) formation. METHODS:The serum leptin concentration was measured by rat leptin RIA kit, long and short forms of leptin receptor (OB-Rb and OB-Ra) mRNA in the brain sections were examined by in situ hybridization (ISH) and the expression of OB-R was assessed by immunohistochemistry ABC method with a highly specific goat anti-OB-R antibody. RESULTS:The level of serum leptin didn't show significant difference between CTA and control group. Comparing with the control group, the CTA group had an increase on count of OB-R immunohistochemistry positive-stained cells in the BLA (127±12 vs 48±9 per 1 mm 2 ). The OB-Rb mRNA expression level enhanced by 11.9 % in the BLA, while OBRa mRNA level increased by 7.4 % on the choroid plexus in CTA group. So BLA was supposed to be a region where interactions between gustatory and vagal signals take place. CONCLUSION:BLA is one of the sites, which are responsible for CTA formation in the brain. Leptin and OB-R maybe involved in neuronal communication for CTA. So leptin and its receptors probably take part in CTA and integration of autonomic and extroceptive information.

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Projections of the Parabrachial Nucleus in the Old World Monkey

Cited by 113 publications

References 118 publications

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Striatal projections of the vagal‐responsive region of the thalamic parafascicular nucleus in macaque monkeys

Beyond flavour to the gut and back

Leptin receptor expression in the basolateral nucleus of amygdala of conditioned taste aversion rats

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