Leptin receptor expression in the basolateral nucleus of amygdala of conditioned taste aversion rats

Han, Zhen; Yan, Jiaqi; Luo, Guo-Gang; Liu, Yong; Wang, Yili

doi:10.3748/wjg.v9.i5.1034

Cited by 14 publications

(14 citation statements)

References 32 publications

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“…Leptin receptors are located in the basolateral amygdala (BLA) (Han et al, 2003), but their impact on behaviors outside of feeding—such as emotion, learning, and behaviors such as fear, aggression, and addiction—remain unclear. In a congenital leptin deficient patient, leptin treatment decreased activation of the amygdala in response to pictures of food (Frank et al, 2011).…”

Section: Leptin’s Role In Psychopathologymentioning

confidence: 99%

The impact of leptin on perinatal development and psychopathology

Valleau

Sullivan

2014

Journal of Chemical Neuroanatomy

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Leptin has long been associated with metabolism as it is a critical regulator of both food intake and energy expenditure, but recently, leptin dysregulation has been proposed as a mechanism of psychopathology. This review discusses the evidence supporting a role for leptin in mental health disorders and describes potential mechanisms that may underlie this association. Leptin plays a critical role in pregnancy and in fetal growth and development. Leptin’s role and profile during development is examined in available human studies and the validity of applying studies conducted in animal models to the human population are discussed. Rodents experience a postnatal leptin surge, which does not occur in humans or larger animal models. This suggests that further research using large mammal models, which have a leptin profile across pregnancy and development similar to humans, are of high importance. Maternal obesity and hyperleptinemia correlate with increased leptin levels in the umbilical cord, placenta, and fetus. Leptin levels are thought to impact fetal brain development; likely by activating proinflammatory cytokines that are known to impact many of the neurotransmitter systems that regulate behavior. Leptin is likely involved in behavioral regulation as leptin receptors are widely distributed in the brain, and leptin influences cortisol release, the mesoaccumbens dopamine pathway, serotonin synthesis, and hippocampal synaptic plasticity. In humans, both high and low levels of leptin are reported to be associated with psychopathology. This inconsistency is likely due to differences in the metabolic state of the study populations. Leptin resistance, which occurs in the obese state, may explain how both high and low levels of leptin are associated with psychopathology, as well as the comorbidity of obesity with numerous mental illnesses. Leptin resistance is likely to influence disorders such as depression and anxiety where both high and low leptin levels have been correlated with symptomatology. Schizophrenia is also associated with both low and high leptin levels. However, as antipsychotics pharmacotherapy induces weight gain, which elevates leptin levels, drug-naïve populations are needed for further studies. Elevated circulating leptin is consistently found in childhood neurodevelopmental disorders including Autism Spectrum Disorders and Rhett disorder. Further studies on the impact of leptin and leptin resistance on psychopathology and neurodevelopmental disorders are important directions for future research. Studies examining the mechanisms by which exposure to maternal obesity and hyperleptinemia during fetal development impact brain development and behavior are critical for the health of future generations.

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Section: Leptin’s Role In Psychopathologymentioning

confidence: 99%

The impact of leptin on perinatal development and psychopathology

Valleau

Sullivan

2014

Journal of Chemical Neuroanatomy

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“…serotonergic raphe nuclei [31] and anxiety behavior, e.g. amygdala were reported to express leptin receptors [32]. In addition, the hippocampus, an anatomical site that governs cognitive functions and spatial learning, express LRb receptor isoform.…”

Section: Introductionmentioning

confidence: 99%

Neurobehavioral deficits in db/db diabetic mice

Sharma¹,

Elased²,

Garrett³

et al. 2010

Physiology & Behavior

150

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Recent clinical studies indicate neurobehavioral disturbances in type-2 diabetics. However, there is paucity of preclinical research to support this concept. The validity of db/db mouse as an animal model to study type-2 diabetes and related complications is known. The present study was designed to investigate comprehensively the db/db mouse behavior as preclinical evidence of type-2 diabetes related major neurobehavioral complications. We tested juvenile (5–6 weeks) and adult (10–11 weeks) db/db mice for behavioral depression in forced swim test (FST), psychosis-like symptoms using pre-pulse inhibition (PPI) test, anxiety behavior employing elevated plus maze (EPM) test, locomotor behavior and thigmotaxis using open field test and working memory deficits in Y-maze test. Both juvenile and adult group db/db mice displayed behavioral despair with increased immobility time in FST. There was an age-dependent progression of psychosis-like symptoms with disrupted PPI in adult db/db mice. In the EPM test, db/db mice were less anxious as observed by increased percent open arms time and entries. They were also hypolocomotive as evident by a decrease in their basic and fine movements. There was no impairment of working memory in the Y-maze test in db/db mice. This is the first report of depression, psychosis-like symptoms and anxiolytic behavior of db/db mouse strain. It is tempting to speculate that this mouse strain can serve as useful preclinical model to study type-2 diabetes related neurobehavioral complications.

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“…Recent studies have shown that dysregulation of leptin may be related to mechanisms of psychopathology, including various emotional changes, such as anxiety, depression, sleep disorders, and suicide [18,19]. In addition, the leptin receptors and their projections in the amygdala, which is a major structure for anxiety and stress-related emotional changes, offer another basis for the association with emotional changes [20]. Females, compared to males, show increased levels of morning plasma leptin after sleep restriction [21].…”

Section: Discussionmentioning

confidence: 99%

Gender Difference in the Effect of Short Sleep Time on Suicide among Korean Adolescents

Park

Kim²,

Kim

2019

IJERPH

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A close association between the duration of sleep and suicide has been reported in previous studies. This study was designed to investigate whether there is a difference in the effects of sleep duration on suicide by gender. This study was conducted based on the results of a volunteer online survey for adolescents in middle and high school in the Republic of Korea. The results showed that the effect of a depressive mood on short sleep time and on suicide was not different between male and female adolescents. It has been reported that the direct effect of short sleep time on increasing suicidal ideation is 2.50 times higher in female than in male adolescents. Differences in the metabolism of sex hormones and sleep-associated neurotransmitters might have affected this result, but further studies are needed to clarify more obvious mechanisms. In addition, this result should be considered when establishing sleep education for adolescents.

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Leptin receptor expression in the basolateral nucleus of amygdala of conditioned taste aversion rats

Cited by 14 publications

References 32 publications

The impact of leptin on perinatal development and psychopathology

The impact of leptin on perinatal development and psychopathology

Neurobehavioral deficits in db/db diabetic mice

Gender Difference in the Effect of Short Sleep Time on Suicide among Korean Adolescents

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