Projected supportive effects of PycnogenolⓇ in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection

Weichmann, Franziska; Rohdewald, Peter

doi:10.1016/j.ijantimicag.2020.106191

Cited by 10 publications

(15 citation statements)

References 127 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several clinical studies with patients having no or particular comorbidities showed that PycnogenolⓇ can improve endothelial function (Enseleit et al, 2012;Nishioka et al, 2007;Weichmann and Rohdewald, 2020;Zibadi et al, 2008). The suggested mechanism of action is activation of the endothelial nitric oxide synthase (eNOS), thus amplifying the NO generation from L-arginine, eventually leading to an increase in vessel lumen and adequate tissue perfusion.…”

Section: Improvement Of Endothelial Healthmentioning

confidence: 99%

“…Urinary albumin levels significantly decreased and kidney cortical blood flow increased in patients taking PycnogenolⓇ in addition to an ACE inhibitor, compared with subjects medicated only with the ACE inhibitor for 6 months (Cesarone et al, 2010;Stuard et al, 2010). PycnogenolⓇ has the potential to act favorably and bring microcirculation to normal levels (Weichmann and Rohdewald, 2020).…”

Section: Improvement Of Microcirculationmentioning

confidence: 99%

“…Standard therapy included aspirin (100% of patients), statins (87%), ACE inhibitors/angiotensin receptor blockers (78%), βblockers (74%), diuretics (35%), calcium antagonists (17%), clopidogrel (17%), ezetimibe (17%), oral antidiabetics (17%), phenprocoumon (4%), and α-antagonists (4%). There were no adverse drug-herb interactions (Enseleit et al, 2012;Weichmann and Rohdewald, 2020).…”

Section: Introductionmentioning

confidence: 98%

“…Pycnogenol is highly protective properties against several diseases such as cardiovascular dysfunctions, kidney diseases, hepatic dysfunctions, neuro cognitive disorder, diabetes, reproductive dysfunction and infertility, cancer, digestive, retinal disease (Weichmann and Rohdewald, 2020). PycnogenolⓇ is extracted from the bark of maritime pine trees (Pinus pinaster) originating from France.…”

Section: Introductionmentioning

confidence: 99%

“…PycnogenolⓇ meets the specifications for maritime pine extract, detailed in the United States Pharmacopeia (USP). The procyanidins are biopolymers consisting of units of catechin and epicatechin, with most chain lengths of 2-12 monomeric units (Oliff, 2019;Weichmann and Rohdewald, 2020).…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The possible protective effects and mechanisms of action of Pycnogenol: in vivo animals and human studies

Al-Abkal

Khodeer

Moustafa

2021

Records of Pharmaceutical and Biomedical Sciences

View full text Add to dashboard Cite

Pycnogenol (PYC) is a plant-based extract derived from the proprietary bark of the French maritime pine (Pinus pinaster ssp. atlantica) that exerts antioxidative, anti-inflammatory, and anti-platelet effects. The standardized extract is composed of phenolic compounds (catechin, epicatechin, and taxifolin), condensed flavonoids (classed as procyanidins/ proanthocyanidins) and phenolic acids (cinnamic acids and other glycosides). These phenolic compounds after being ingested, undergo biotransformation and are broken down in the colon by microbial enzymes yielding smaller, bioavailable molecules that can then be absorbed by the colon into the bloodstream and transported to tissues and organs. The pycnogenol possess a highly protective characteristics versus various cardiovascular dysfunctions, kidney diseases, hepatic dysfunctions, neuro cognitive disorder, diabetes, reproductive dysfunction and infertility, cancer, digestive, retinal disease. The present review illustrates the effect of Pycnogenol as antioxidant and anti-inflammatory effects along with anti-tumor influence as well. Pycnogenol was concluded to act as an antioxidant agent in different situation including heart stress, cardiovascular system abnormalities, kidney disease and hepatic disorders, so it can be used in combination with other medication such as Methotrexate to abolish its side effects.

show abstract

Section: Improvement Of Endothelial Healthmentioning

confidence: 99%

Section: Improvement Of Microcirculationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The possible protective effects and mechanisms of action of Pycnogenol: in vivo animals and human studies

Al-Abkal

Khodeer

Moustafa

2021

Records of Pharmaceutical and Biomedical Sciences

View full text Add to dashboard Cite

show abstract

The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

Nattagh‐Eshtivani

Gheflati

Barghchi

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

The prevalence of chronic diseases has increased significantly with the rising trend of sedentary lifestyles, reduced physical activity, and dietary modifications in recent decades. Inflammation and oxidative stress play a key role in the pathophysiology of several chronic diseases, such as type II diabetes, cardiovascular diseases, and hepatic conditions. Therefore, reducing inflammation and oxidative stress may be beneficial in the prevention and treatment of various chronic disorders. Since chronic diseases are not completely curable, various methods have been proposed for their control. Complementary therapies and the use of natural antioxidant and antiinflammatory compounds are among these novel approaches. Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. Furthermore, some previous studies have shown that PYC could effectively reduce inflammation through signaling the downstream of insulin receptors, inhibiting the phosphorylation of the serine residues of insulin receptor substrate‐1, reducing pro‐inflammatory cytokines and oxidative stress indices through the stimulation of antioxidant pathways, increasing free radical scavenging activities, preventing lipid peroxidation, and protecting the erythrocytes in glucose‐6‐phosphate dehydrogenase‐deficient individuals, although these effects have not been fully proved. The present study aimed to comprehensively review the evidence concerning the positive physiological and pharmacological properties of PYC, with an emphasis on the therapeutic potential of this natural component for enhancing human health.

show abstract

Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses

Ide

Kitab

Ito

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Foot-and-mouth disease virus (FMDV) and classical swine fever virus (CSFV) possess positive-sense single-stranded RNA genomes and an internal ribosomal entry site (IRES) element within their 5′-untranslated regions. To investigate the common host factors associated with these IRESs, we established cell lines expressing a bicistronic luciferase reporter plasmid containing an FMDV-IRES or CSFV-IRES element between the Renilla and firefly luciferase genes. First, we treated FMDV-IRES cells with the French maritime pine extract, Pycnogenol (PYC), and examined its suppressive effect on FMDV-IRES activity, as PYC has been reported to have antiviral properties. Next, we performed microarray analysis to identify the host factors that modified their expression upon treatment with PYC, and confirmed their function using specific siRNAs. We found that polycystic kidney disease 1-like 3 (PKD1L3) and ubiquitin-specific peptidase 31 (USP31) were associated with FMDV-IRES activity. Moreover, silencing of these factors significantly suppressed CSFV-IRES activity. Thus, PKD1L3 and USP31 are host factors associated with the functions of FMDV- and CSFV-IRES elements.

show abstract

Projected supportive effects of PycnogenolⓇ in patients suffering from multi-dimensional health impairments after a SARS-CoV2 infection

Cited by 10 publications

References 127 publications

The possible protective effects and mechanisms of action of Pycnogenol: in vivo animals and human studies

The possible protective effects and mechanisms of action of Pycnogenol: in vivo animals and human studies

The role of Pycnogenol in the control of inflammation and oxidative stress in chronic diseases: Molecular aspects

Characterization of host factors associated with the internal ribosomal entry sites of foot-and-mouth disease and classical swine fever viruses

Contact Info

Product

Resources

About