Project Sanguine Biological Effects Test Program Pilot Studies

Coate, William B.; Kimball, Robert E.; Negherbon, William O.; Hoo, Smit Sea; Pledger, Richard A.

doi:10.21236/ad0717409

Cited by 8 publications

(3 citation statements)

References 2 publications

(3 reference statements)

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“…Many of these results cannot be directly compared to other investigators' findings. Cerretelli and Malaguti (1976), Gann (personal communication, 1976), Coate and Teeters (1970) and each used different species of animals in their studies. Also, in one of those studies, 45-, 50-and 75-Hz frequencies were used, whereas our study used a 60-Hz frequency exclusively.…”

Section: Discussionmentioning

confidence: 99%

“…Also, in one of those studies, 45-, 50-and 75-Hz frequencies were used, whereas our study used a 60-Hz frequency exclusively. In the experiment by Coate and Teeters (1970), the animals were exposed not only to electric fields, but also to a magnetic field and a ground current. The observed effects might have been due to any one or a combination of these three components.…”

Section: Discussionmentioning

confidence: 99%

“…Cerretelli and Malaguti (1976) reported that arterial blood pressure in rabbits exposed to 50-Hz fields at 80 kV/m for 500 hr tended to be higher than in controls. Coate and Teeters (1970) measured blood pressure in dogs exposed to 45-Hz or 75-Hz electric fields at 10 kV/m, a magnetic field of 1 gauss and a 0.5-mA ground current. He found that the animals had significantly elevated arterial pressure after 3 wk of exposure.…”

Section: A Introductionmentioning

confidence: 99%

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Biological effects of high-strength electric fields on small laboratory animals. Interim report, March 1, 1978-September 30, 1979

Phillips¹,

Anderson²,

Kaune³

1979

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SeruliT glutamTc^oxaloacetic transaminase ** Blood urea nitrogen *** Total iron binding capacity * I/[lerniient 'I -Hematology and chemistry done separately on two different groups of mice, •* l/perniient -2 -Hematology and chemistry done on same group of animals, *** S<>ru'ii qlutaiiiu oxaloacetic transaminase. * Volume Packed Red Cells ** Mean Corpuscular Volume *** Mean Corpuscular Hemoglobin Concentration »r**Ar f^gairi Corpuscular Hemoglobin * Serum qlutaiinc oxaloacetic transaminase ** Lactic dehydroqenese *** Blood urea nitrogen

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: A Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biological effects of high-strength electric fields on small laboratory animals. Interim report, March 1, 1978-September 30, 1979

Phillips¹,

Anderson²,

Kaune³

1979

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Cardiovascular response of rats exposed to 60‐Hz electric fields

Hilton

Phillips

1980

Bioelectromagnetics

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Recently, it has been reported that exposure to high-strength electric fields can influence electrocardiogram (ECG) patterns, heart rates, and blood pressures in various species of animals. Our studies were designed to evaluate these reported effects and to help clarify some of the disagreement present in the literature. Various cardiovascular variables were measured in Sprague-Dawley rats exposed or sham-exposed to 60-Hz electric fields at 80 or 100 kV/m for periods up to four months. No significant differences in heart rates, ECG patterns, blood pressures, or vascular reactivity were observed between exposed and sham-exposed rats after 8 hours, 40 hours, 1 month, or 4 months of exposure. Blood pressure and heart rate measurements, made during exposure to a 100-kV/m electric field for one hour, revealed no significant differences between exposed and sham-exposed groups. In addition, physiologic reserve capacity, measured in rats subjected to low temperature after exposure to 100 kV/m for one month, showed that electric-field exposure had no significant effect on physiological response to cold stress. Our studies cannot be directly compared to the work of other investigators because of differences in animal species and electric-field characteristics. However, our failure to detect any cardiovascular changes may have been the result of 1) eliminating secondary field effects such as shocks, audible noise, corona, and ozone; 2) minimizing steady-state micro-currents between the mouth of the animal and watering devices; and 3) minimizing electric-field-induced vibration of the electrodes and animal cages.

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Studies on prenatal and postnatal development in rats exposed to 60‐Hz electric fields

Sikov

Montgomery

Smith

et al. 1984

Bioelectromagnetics

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A series of three experiments was performed to determine the effects of 30-day exposures to uniform 60-Hz electric fields (100 kV/m) on reproduction and on growth and development in the fetuses and offspring of rats. In the first experiment, exposure of females for 6 days prior to and during the mating period did not affect their reproductive performance, and continued exposure through 20 days of gestation (dg) did not affect the viability, size, or morphology of their fetuses. In the second experiment, exposure of the pregnant rat was begun on 0 dg and continued until the resulting offspring reached 8 days of age. In the third experiment, exposure began at 17 dg and continued through 25 days of postnatal life. In the second and third experiments, no statistically significant differences suggesting impairment of the growth or survival of exposed offspring were detected. In the second experiment, a significantly greater percentage of the exposed offspring showed movement, standing, and grooming at 14 days of age than among-sham-exposed offspring. There was a significant decrease at 14 days in the percentage of exposed offspring displaying the righting reflex in the second experiment and negative geotropism in the third experiment. These differences were all transient and were not found when the animals were tested again at 21 days of age. Evaluation of the reproductive integrity of the offspring of the second experiment did not disclose any deficits.

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Project Sanguine Biological Effects Test Program Pilot Studies

Cited by 8 publications

References 2 publications

Biological effects of high-strength electric fields on small laboratory animals. Interim report, March 1, 1978-September 30, 1979

Biological effects of high-strength electric fields on small laboratory animals. Interim report, March 1, 1978-September 30, 1979

Cardiovascular response of rats exposed to 60‐Hz electric fields

Studies on prenatal and postnatal development in rats exposed to 60‐Hz electric fields

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