Project profile: a multicenter study on breast cancer in young women in Latin America (PRECAMA study)

Romieu, Isabelle; Biessy, Carine; Torres-Mejı́a, Gabriela; Ángeles-Llerenas, Angélica; Sánchez, Gloria Inés; Borrero, Mauricio; Ossa, Carlos Andrés; Porras, Carolina; Rodríguez, Ana Cecilia; Ocampo, Rebecca; Garmendia, María Luisa; Bustamante, Eva; Olivier, Magalí; Porter, Peggy L.; Rinaldi, Sabina

doi:10.21149/10466

Cited by 7 publications

(13 citation statements)

References 36 publications

(53 reference statements)

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“…There is more evidence to support that EOBC somatic mutation profile is different from that of late-onset breast cancer. In a study that examined young Latin American breast cancer patients, TP53 mutations showed an unexpected pattern of mutations not common in breast cancer, where 27% of the mutations were single-base substitutiontransversion mutations G:C > T:A compared to other young and old breast cancer cohorts used for comparison (METABRIC, TCGA, and International Agency for Research on Cancer IARC) [45]. This proportion and pattern of mutations were described earlier in lung cancer patients and attributed to exposure to exogenous agent, polycyclic aromatic hydrocarbons (PAHs) [46].…”

Section: Somatic Mutationsmentioning

confidence: 99%

The Unique Biology behind the Early Onset of Breast Cancer

Siddig

Din

Nafi

et al. 2021

Genes

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Breast cancer commonly affects women of older age; however, in developing countries, up to 20% of breast cancer cases present in young women (younger than 40 years as defined by oncology literature). Breast cancer in young women is often defined to be aggressive in nature, usually of high histological grade at the time of diagnosis and negative for endocrine receptors with poor overall survival rate. Several researchers have attributed this aggressive nature to a hidden unique biology. However, findings in this aspect remain controversial. Thus, in this article, we aimed to review published work addressing somatic mutations, chromosome copy number variants, single nucleotide polymorphisms, differential gene expression, microRNAs and gene methylation profile of early-onset breast cancer, as well as its altered pathways resulting from those aberrations. Distinct biology behind early-onset of breast cancer was clear among estrogen receptor-positive and sporadic cases. However, further research is needed to determine and validate specific novel markers, which may help in customizing therapy for this group of patients.

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Section: Somatic Mutationsmentioning

confidence: 99%

The Unique Biology behind the Early Onset of Breast Cancer

Siddig

Din

Nafi

et al. 2021

Genes

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“…Methods the pRecAMA study. PRECAMA is an ongoing multicentric population-based case-control study based in Chile, Colombia, Costa Rica, Mexico, and Brazil (pilot phase) [11][12][13] . At recruitment, information was collected on lifestyle, health and reproductive history.…”

mentioning

confidence: 99%

“…Selection of cases and controls. Incident cases of primary invasive breast cancer were recruited from general or cancer-specific hospitals or private oncology institutes, encompassing populations with a wide range of socio-economic status 13 . The inclusion criteria were: age 20-45 years; being resident for ≥3 years in the same city district; having an incident primary invasive BC with positive biopsy and clinical staging and having menstruated at least once in the past 12 months.…”

mentioning

confidence: 99%

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Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study

His

Biessy

Torres-Mejı́a

et al. 2020

Sci Rep

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pRecAMA team † cumulating evidence in caucasian women suggests a positive association between height and premenopausal breast cancer risk and a negative association with overall adiposity; however data from Latin America are scarce. We investigated the associations between excess adiposity, body shape evolution across life, and risk of premenopausal breast cancer among 406 cases (women aged 20-45) and 406 matched population-based controls from Chile, Colombia, Costa Rica, and Mexico. Negative associations between adult adiposity and breast cancer risk were observed in adjusted models (body mass index (BMI): Odds ratio (OR) per 1 kg/m 2 = 0.93; 95% confidence interval = 0.89-0.96; waist circumference (WC): OR per 10 cm = 0.81 (0.69-0.96); hip circumference (HC): OR per 10 cm = 0.80 (0.67-0.95)). Height and leg length were not associated with risk. In normal weight women (18.5 ≤ BMi < 25), women with central obesity (WC > 88 cm) had an increased risk compared to women with normal WC (OR = 3.60(1.47-8.79)). Residuals of WC over BMI showed positive associations when adjusted for BMI (OR per 10 cm = 1.38 (0.98-1.94)). Body shape at younger ages and body shape evolution were not associated with risk. no heterogeneity was observed by receptor status. in this population of Latin American premenopausal women, different fat distributions in adulthood were differentially associated with risk of breast cancer.Although breast cancer is the most commonly diagnosed cancer among women worldwide 1 , the age distribution of the cases varies between different regions of the world. While only 12.4% of the women diagnosed with breast cancer in 2018 were younger than 45 years old in high-income countries, this proportion reached 21% in Latin America 1 . It has been shown that only part of this difference can be attributed to the difference in the age structure of the population 2 , suggesting a possible role for specific etiologic factors. However, to date only a few studies have investigated risk factors for premenopausal breast cancer among women in

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“…Women with incident primary invasive breast cancer cases were recruited from major cancer hospitals in four Latin American countries before any therapies. 12 The inclusion criteria were: age 20-45 years; being resident for ≥3 years in the same city district; having an incident primary invasive breast cancer with positive biopsy and clinical staging according to TNM standards and having menstruated at least once in the past 12 months. To date 525 primary invasive breast cancer incident cases have been recruited among premenopausal women (40 in Chile, 129 in Colombia, 43 in Costa Rica and 313 in Mexico).…”

Section: Selection Of Cases and Controlsmentioning

confidence: 99%

Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study

Romieu

Katsikari

Biessy

et al. 2022

BMJNPH

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Ultra-processed food intake has been linked to an increased risk of breast cancer in Western populations. No data are available in the Latin American population although the consumption of ultra-processed foods is increasing rapidly in this region.We evaluated the association of ultra-processed food intake to breast cancer risk in a case–control study including 525 cases (women aged 20–45 years) and 525 matched population-based controls from Chile, Colombia, Costa Rica and Mexico. The degree of processing of foods was classified according to the NOVA classification.Overall, the major contributors to ultra-processed food intake were ready-to-eat/heat foods (18.2%), cakes and desserts (16.7%), carbonated and industrial fruit juice beverages (16.7%), breakfast cereals (12.9%), sausages and reconstituted meat products (12.1%), industrial bread (6.1%), dairy products and derivatives (7.6%) and package savoury snacks (6.1%). Ultra-processed food intake was positively associated with the risk of breast cancer in adjusted models (OR T3-T1=1.93; 95% CI=1.11 to 3.35). Specifically, a higher risk was observed with oestrogen receptor positive breast cancer (ORT3-T1=2.44, (95% CI=1.01 to 5.90, P-trend=0.049), while no significant association was observed with oestrogen receptor negative breast cancer (ORT3-T1=1.87, 95% CI=0.43 to 8.13, P-trend=0.36).Our findings suggest that the consumption of ultra-processed foods might increase the risk of breast cancer in young women in Latin America. Further studies should confirm these findings and disentangle specific mechanisms relating ultra-processed food intake and carcinogenic processes in the breast.

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Project profile: a multicenter study on breast cancer in young women in Latin America (PRECAMA study)

Abstract: Project profile: a multicenter study on breast cancer in young women in Latin America (PRECAMA study).

Cited by 7 publications

References 36 publications

The Unique Biology behind the Early Onset of Breast Cancer

The Unique Biology behind the Early Onset of Breast Cancer

Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study

Consumption of industrial processed foods and risk of premenopausal breast cancer among Latin American women: the PRECAMA study

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