Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study

His, Mathilde; Biessy, Carine; Torres-Mejı́a, Gabriela; Ángeles-Llerenas, Angélica; Alvarado‐Cabrero, Isabel; Sánchez, Gloria Inés; Borrero, Mauricio; Porras, Carolina; Rodríguez, Ana Cecilia; Garmendia, María Luisa; Olivier, Magalí; Porter, Peggy L.; Lin, Ming-Gang; Gunter, Marc J.; Romieu, Isabelle; Rinaldi, Sabina; team, Precama

doi:10.1038/s41598-020-59056-6

Cited by 12 publications

(12 citation statements)

References 41 publications

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“…These findings are consistent with an earlier study that demonstrated increased postmenopausal breast cancer risk among normal-BMI women with relatively elevated fasting insulin levels, while those with lower fasting insulin were not found to have increased risk regardless of weight status (30). Whether MONW also raises the risk of premenopausal breast cancer is less clear, with some studies reporting significant associations (26,27,31) while others have not (28). Consistent with the link between MONW and ER+ breast cancer, there is also emerging evidence of an increased risk of endometrial cancer, another hormonally driven cancer (29,32).…”

Section: Breast and Endometrial Cancerssupporting

confidence: 90%

Cancer Risk in Normal Weight Individuals with Metabolic Obesity: A Narrative Review

Liu

Giffney

Arthur

et al. 2021

Cancer Prevention Research

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Obesity represents one of the most significant public health challenges worldwide. Current clinical practice relies on body mass index (BMI) to define the obesity status of an individual, even though the index has long been recognized for its limitations as a measure of body fat. In normal BMI individuals, increased central adiposity has been associated with worse health outcomes, including increased risks of cardiovascular disease and metabolic disorders. The condition leading to these outcomes has been described as metabolic obesity in the normal weight (MONW). More recent evidence suggests that MONW is associated with increased risk of several obesity-related malignancies, including postmenopausal breast, endometrial, colorectal, and liver cancers. In MONW patients, the false reassurance of a normal range BMI can lead to lost opportunities for implementing preventive interventions that may benefit a substantial number of people. A growing body of literature has documented the increased risk profile of MONW individuals and demonstrated practical uses for body composition and biochemical analyses to identify this at-risk population. In this review, we survey the current literature on MONW and cancer, summarize pathophysiology and oncogenic mechanisms, highlight potential strategies for diagnosis and treatment, and suggest directions for future research.

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Section: Breast and Endometrial Cancerssupporting

confidence: 90%

Cancer Risk in Normal Weight Individuals with Metabolic Obesity: A Narrative Review

Liu

Giffney

Arthur

et al. 2021

Cancer Prevention Research

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“…Mexican researchers have found that height, BMI, waist, thighs circumferences and their ratio are associated with the risk of breast cancer (from p<0.001 to p<0.016) [2]. Similar data on the relationship of anthropometric parameters with the risk of breast cancer have been found in other works [12,21].…”

Section: Discussionsupporting

confidence: 67%

Features of total and longitudinal body sizes in men with benign nevi

et al. 2021

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The use of anthropometric markers to predict the onset or severity of the disease is key to solving the problem of preventive medicine and can be an indispensable tool in preventive examinations in schools, universities and industries. The purpose of the study was to establish total and longitudinal body sizes in men of the first mature age with benign nevi. Anthropometry (determination of total and longitudinal body sizes) was performed according to Bunak’s scheme for men (aged 22-35 years) patients with melanocytic benign simple nevi (n=34), melanocytic benign dysplastic nevi (n=27), melanocytic benign congenital nevi (n=14) and non-melanocytic benign nevi (n=17). As a control from the data bank of the research center of National Pirogov Memorial Medical University, Vinnytsya selected total and longitudinal body sizes of 82 practically healthy men of the same age group. Statistical processing of the obtained results was performed in the license package “Statistica 5.5” using non-parametric evaluation methods. It was found that the mass and surface area of the body in healthy men is lower than in patients (except for dysplastic nevi), and in patients with dysplastic nevi – lower than in patients with non-melanocytic nevi; the height of the suprathoracic, acromial and finger anthropometric points in healthy men is lower than in patients with nevi (except for the acromial point height in patients with dysplastic nevi), and the height of the pubic and acetabular anthropometric points – in healthy men is greater than in patients with simple (only pubic point) and dysplastic nevi; in addition, the height of the pubic and acetabular anthropometric points in patients with simple nevi is lower than in patients with non-melanocytic nevi and congenital nevi (only for the acetabulum height). Given the height of anthropometric points and the fact that body length between healthy and sick men has no significant or tendency differences, in sick men we observe a longer torso and shorter lower extremities (most pronounced in patients with simple and dysplastic nevi), which is a manifestation of “subpathological” constitutional types, which indicate a longer torso and shorter lower extremities.

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“…28 Other studies proposed that obese women in early adulthood have decreased premenopausal cancer risk, irrespective of later weight gain 10 and that body shape evolution was not associated with premenopausal breast cancer risk. 29 This evidence suggests a possible benefit of obesity in early life. However, another study suggested that the association with weight gain was stronger in women with high WC.…”

Section: Discussionmentioning

confidence: 96%

Changes in weight and waist circumference during menopausal transition and postmenopausal breast cancer risk

Park

2021

Intl Journal of Cancer

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Our study aimed to investigate the association between changes in weight and waist circumference (WC) during menopausal transition and breast cancer risk in Asian women. In total, 184 931 women aged 40 to 59 years with a premenopausal status at the first screening in 2009 to 2010 and a postmenopausal status at the second screening in 2011 to 2012 were included in the analysis. Changes in weight and WC during menopausal transition were classified as loss (>2.5 kg; >2.5 cm), stable (±2.5 kg; ±2.5 cm), and gain (2.5‐4.9 kg, ≥5 kg; 2.5‐4.9 cm, ≥5 cm). WC gain of 5 cm or more during menopausal transition was associated with an increased risk of breast cancer with an HR of 1.15 (95% CI = 1.01‐1.30), compared to stable WC (±2.5 cm). Among obese premenopausal women, increased WC ≥5 cm during menopausal transition was associated with increased breast cancer risk with an HR of 1.22 (95% CI = 1.03‐1.44). Similarly, in women with premenopausal WC ≥80 cm, increased WC of ≥5 cm during menopausal transition was likely to increase the breast cancer risk (HR = 1.36, 95% CI = 1.13‐1.88) than in women with stable WC. However, in premenopausal women with BMI <23 kg/m2 or WC <80 cm, changes in WC during menopausal transition did not show an association. Weight gain during menopausal transition was not associated with the risk of breast cancer. Changes in central obesity during menopausal transition in combination with premenopausal obesity status are associated with breast cancer risk after menopause.

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Anthropometry, body shape in early-life and risk of premenopausal breast cancer among Latin American women: results from the PRECAMA study

Cited by 12 publications

References 41 publications

Cancer Risk in Normal Weight Individuals with Metabolic Obesity: A Narrative Review

Cancer Risk in Normal Weight Individuals with Metabolic Obesity: A Narrative Review

Features of total and longitudinal body sizes in men with benign nevi

Changes in weight and waist circumference during menopausal transition and postmenopausal breast cancer risk

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