Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome

Barkhordari, Elham; Rezaei, Nima; Ansaripour, Bita; Larki, Pegah; Alighardashi, Maryam; Ahmadi-Ashtiani, Hamid Reza; Mahmoudi, Mahdi; Keramati, Mohammad Reza; Habibollahi, Peiman; Bashashati, Mohammad; Ebrahimi-Daryani, Naser; Amirzargar, Ali Akbar

doi:10.1007/s10875-009-9342-4

Cited by 70 publications

(55 citation statements)

References 31 publications

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“…The relationship between the G allele and susceptibility to diseases was also observed for irritable bowel syndrome (Barkhordari et al, 2010) and lupus erythematosus (Hamdy et al, 2012). We also evidenced higher frequencies of the GG and GC genotypes, as well as the G allele in the region -174 of the IL-6 gene in both CD patients and healthy controls, but these differences were not significant.…”

Section: Discussionsupporting

confidence: 60%

Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

et al. 2015

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ABSTRACT. The aim of this research was to study polymorphisms in the genes encoding cytokines interleukin-6 (IL-6) and tumor necrosis factoralpha (TNF-α) in patients with celiac disease (CD) antigens DQ2 (DQ2-positive) or DQ8 (DQ8-positive). We compared the results with healthy controls to determine whether any of the polymorphisms have a role in susceptibility to CD. 16343-16352 (2015) included in the study. Analysis of single nucleotide polymorphisms (SNPs) was carried out using the polymerase chain reaction-restriction fragment length polymorphism method. Significant differences for the TNF-α (-308 G>A) polymorphism were observed when we compared the flowing groups: DQ2-positive with controls [odds ratio (OR) = 0.45, P = 0.0002]; DQ8-positive with controls (OR = 3.55, P < 0.0001); and DQ2-positive with DQ8-positive (OR = 0.12, P < 0.0001). We did not observe a statistically significant association between IL-6 (-174 G>C) polymorphism and CD (P > 0.05). Our results suggest that TNF-α (-308 G>A) polymorphism may play a role in susceptibility to CD in Italian patients.

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Section: Discussionsupporting

confidence: 60%

Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

et al. 2015

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“…Evidence supporting this hypothesis includes increased concentrations of inflammatory/immune cells in intestinal tissue from IBS patients, altered levels of pro-and anti-inflammatory cytokines in the GI tract and peripheral blood of patients with IBS (Table 1) (11, 13, 24, 36, 46, 50, 51, 62, 73, 75, 89, 90, 94, 98, 102, 118, 121-124, 168, 174, 185, 187), and IBS-associated polymorphisms in genes involved in immune and inflammatory responses (Table 2) (15,16,70,179,184). This topic has been thoroughly reviewed recently (27).…”

Section: Altered Intestinal Immune Function In Ibsmentioning

confidence: 99%

Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome

Ringel

Maharshak

2013

American Journal of Physiology-Gastrointestinal and Liver Physi

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Ringel Y, Maharshak N.Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 305: G529-G541, 2013. First published July 25, 2013; doi:10.1152/ajpgi.00207.2012.-The pathophysiology of irritable bowel syndrome (IBS) is believed to involve alterations in the brain-gut axis; however, the etiological triggers and mechanisms by which these changes lead to symptoms of IBS remain poorly understood. Although IBS is often considered a condition without an identified "organic" etiology, emerging evidence suggests that alterations in the gastrointestinal microbiota and altered immune function may play a role in the pathogenesis of the disorder. These recent data suggest a plausible model in which changes in the intestinal microbiota and activation of the enteric immune system may impinge upon the brain-gut axis, causing the alterations in gastrointestinal function and the clinical symptoms observed in patients with IBS. This review summarizes the current evidence for altered intestinal microbiota and immune function in IBS. It discusses the potential etiological role of these factors, suggests an updated conceptual model for the pathogenesis of the disorder, and identifies areas for future research.inflammation; gastrointestinal; microbiota IRRITABLE BOWEL SYNDROME (IBS) is the most common and best studied condition of a larger group of functional gastrointestinal (GI) disorders. Functional GI disorders refer to the presence of a variable combination of chronic or recurrent GI symptoms not explained by structural or biochemical abnormalities (130,159). IBS is characterized by chronic or recurring abdominal pain or discomfort that is associated with altered bowel habits (53, 99). The condition is often associated with other GI symptoms (e.g., bloating, distention, and gas), other functional GI disorders (e.g., functional dyspepsia), other non-GI disorders (e.g., fibromyalgia, interstitial cystitis, migraine headache), and psychological disorders (e.g., depression, anxiety, somatization) (96,146,167). Traditionally, IBS has been subtyped on the basis of the patient's predominant symptom/stool pattern (99). These subtypes include diarrhea predominant (IBS-D), constipation predominant (IBS-C), and mixed type (IBS-M), in which patients experience alternating periods of diarrhea and constipation. Unlike other conditions that can be associated with abdominal pain and abnormal bowel patterns such as inflammatory bowel diseases (IBD), IBS is not associated with any overt histopathology, structural, or biochemical abnormalities. IBS has been generally considered to be caused by alterations in the brain-gut axis (the bidirectional communication network involving the enteric nervous system, the autonomic nervous system, and the central nervous system) (60,108,125), and the pathophysiological mechanisms behind this condition remain unclear. Traditionally, IBS is considered to be a multifactorial condition in which multiple environmental, genetic, physiological, ...

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“…Additionally, significant increases in the plasma levels of proinflammatory cytokines (TNF-α, IL-1b, IL-6 and IL-8) are found in patients with intestinal disorders favoring mucosal inflammation, including constipation-predominant IBS [51,52]. This correlation can be explained by the sustained stimulation of nociceptors in chronic pain by proinflammatory cytokines pathway, resulting in local hypersensitivity, hypersensitivity in the adjacent regions and increased Central Nervous System responsiveness through chemical, physical or mechanical stimuli [53,54].…”

Section: Discussionmentioning

confidence: 99%

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

et al. 2017

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A B S T R A C T ObjectiveTo identify the occurrence of constipation in patients with myofascial pain syndrome and to correlate these disorders with the clinical and nutritional variables. MethodsThis report describes a case-control study performed with 98 adults of both sexs, including 49 patients and 49 individuals without pain. The intensity of the reported pain was evaluated using the Pain Visual Analog Scale, which provided a simple and efficient measurement of pain intensity consisting of a 10cm horizontal line with Revista de NutriçãoRev. Nutri., Campinas, 30(5):567-581, set./out., 2017 https://doi.org/10.1590/1678-98652017000500003 568 JA BARROS-NETO et al.the ends marked "absence of pain" and "worst possible pain". The occurrence of constipation was evaluated using the Rome III criteria. A multivariate linear regression was proposed to investigate risk factors between the frequency of bowel movements per week and independent variables this study. ResultsThe mean ages of the patients and controls were 45.9 (7.6) years and 41.2 (12.2) years, respectively. The intensity of the reported pain showed a mean of 7.3 (1.6) points. The likelihood of exhibiting constipation was 4.5 times higher in the patients than in the controls (p=0.001). The number of stools per week was negatively correlated with the intensity of the reported pain (r=-0.613, p<0.001). The use of benzodiazepines was negatively correlated with the frequency of bowel movements per week, while the use of muscle relaxants appeared to increase the frequency of defecation when combined with the use of benzodiazepines and adjusted for the intake of fiber, water and sexs (p=0.037). ConclusionConstipation was a frequent nosological entity in this patient population and the persistence of a change in intestinal motility showed a significant correlation with the pain intensity and low water intake. The reduction of the number of stools per week seems to be associated with the use of benzodiazepines.Keywords: Chronic pain. Constipation. Myofascial pain syndromes. (r=-0,613, p<0,001 R E S U M O Objetivo Identificar a ocorrência de constipação em pacientes com síndrome dolorosa miofascial e correlacionar essa desordem da motilidade intestinal com variáveis clínicas e nutricionais. Métodos Trata-se de um estudo de caso-controle, realizado com 98 indivíduos adultos de ambos os sexos I N T R O D U C T I O NChronic pain is considered a serious and growing public health problem worldwide. Affected people require medical attention approximately five times more frequently than the rest of the population. These patients have impaired physical, mental and social wellbeing, resulting in disability and work absenteeism [1,2].Myofascial Pain Syndrome (MPS) is characterized by regional chronic muscle pain located in a single muscle or in muscle groups.Revista de Nutrição Rev. Nutri., Campinas, 30(5):567-581, set./out., 2017 CONSTIPATION IN PATIENTS WITH MYOFASCIAL PAIN SYNDROME 569

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Proinflammatory Cytokine Gene Polymorphisms in Irritable Bowel Syndrome

Abstract: IL-6 and TNF-alpha proinflammatory cytokine gene polymorphisms could change individual susceptibility to IBS and might have a role in pathophysiology of disease.

Cited by 70 publications

References 31 publications

Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

Tumor necrosis factor-α and interleukin-6 gene polymorphism association with susceptibility to celiac disease in Italian patients

Intestinal microbiota and immune function in the pathogenesis of irritable bowel syndrome

Constipation in patients with myofascial pain syndrome as important aspect for clinical and nutritional treatment: A case-control study

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