Progressive Transformation of Germinal Centers: Clinical Significance and Lymphocytic Predominance Hodgkinʼs Disease—The Kiel Experience

Lennert, K.; Hansmann, Martin‐Leo

doi:10.1097/00000478-198702000-00011

Cited by 19 publications

(11 citation statements)

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“…Sinus histiocytosis with massive lymphadenopathy has been recorded as a focal finding in lymph nodes involved by Hodgkin disease, especially of the mixed cellularity type [13], so the possibility of a comorbid pathology cannot be overruled. It is also not uncommon for Hodgkin lymphoma to present initially as reactive hyperplasia [11,14], as was observed in this patient .…”

Section: Discussionsupporting

confidence: 68%

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Hodgkin Lymphoma in a Child With Sickle Cell Anemia

Bj¹,

Kotila²

2007

Pediatric Hematology and Oncology

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There are reports of patients with sickle cell disease who developed hematological malignancies but the relationship between these malignancies and sickle cell disease (SCD) is not yet defined. The co-existence of a hematological malignancy with SCD poses certain challenges for the management of each condition. We describe a 7-year-old boy with sickle cell anemia who developed Hodgkin's lymphoma and the challenges of management. He presented with a 4-year history of bilateral neck swelling and a 2-month history of weight loss and high-grade fever. Histology of a lymph node biopsy was consistent with mixed cellularity Hodgkin's lymphoma. He was treated with five cycles of Cyclophosphamide, Vincristine, Procarbazine and Prednisolone (COPP) and had complete clinical response. Chemotherapy was associated with an increase in frequency of painful crises and complicated by septicaemia. Blood transfusion needs were minimal; apart from the transfusion preceding the first cycle of chemotherapy, there was no need for further transfusion. Myelosuppression was not a problem in the patient; he responded well to antibiotics during the two episodes of septicemia without the use of hemopoetic growth factor. Patients with sickle cell anaemia who develop Hodgkin's lymphoma can be successfully treated with chemotherapy along with supportive management for crises and infections.

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Section: Discussionsupporting

confidence: 68%

“…It is not unusual for Hodgkin disease to progressively transform from a lymphoid neoplasm [11,12]. Sinus histiocytosis with massive lymphadenopathy has been recorded as a focal finding in lymph nodes involved by Hodgkin disease, especially of the mixed cellularity type [13], so the possibility of a comorbid pathology cannot be overruled.…”

Section: Discussionmentioning

confidence: 99%

Hodgkin Lymphoma in a Child With Sickle Cell Anemia

Bj¹,

Kotila²

2007

Pediatric Hematology and Oncology

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“…1,2,26,27,[32][33][34] In LPHD, a single clone of lymphocytic and histiocytic cells, characterized as the descendant of a centroblast, is found in the different nodules of the lymphoma. 10,16,17 Although the detection of single clones of Ki67 ϩ cells encompassing 50% to 70% of the mutated Ki67 ϩ cells in 3 PTGCs may be suggestive of aberrant clonal expansions, such expansions are not unusual for classical GCs.…”

Section: Relation Of Ptgcs To Lphdmentioning

confidence: 99%

“…Although relapses are frequent (in approximately 20% of patients), PTGCs are considered nonmalignant lesions. [2][3][4] PTGCs are primarily composed of small, tightly packed CD20 ϩ B cells positive for immunoglobulin M (IgM) and IgD, resembling the mantle zone B cells of secondary follicles. Intermingled are large single or clustered cells that resemble centroblasts.…”

Section: Introductionmentioning

confidence: 99%

B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease

Bräuninger

Yang

Wacker

et al. 2001

Blood

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“…The nodules of LPHD have many structural and immunologic similarities with PTGCs, which may occur as isolated benign reactive processes in lymph nodes. Since PTGCs contain surface immunoglobulin positive lymphocytes, and may represent a precursor lesion of LPHD in some cases, it is possible that other malignant lymphomas of B-cell type such as BL may develop from LPHD (Dorfman, 1987;Lennert & Hansmann, 1987).…”

Section: Discussionmentioning

confidence: 99%

Clonal identification of Burkitt's Lymphoma Arising from Lymphocyte‐Predominant Hodgkin's Disease

et al. 1996

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The occurrence of large cell lymphomas subsequent to, or concurrent with, lymphocyte predominant Hodgkin's disease (LPHD) is a well-documented phenomenon. We present a case of Burkitt's lymphoma of the bladder, occurring after the successful treatment of LPHD of a cervical lymph node. To evaluate the clonal relationship of the two tumours, we amplified the complementarity-determining-region 3 of two samples from paraffin-embedded slides, using the polymerase chain reaction (PCR). The sequences of the PCR products showed 96% homology to each other. These results indicate that the malignant clone of Burkitt's lymphoma arose from the corresponding LPHD.

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Progressive Transformation of Germinal Centers: Clinical Significance and Lymphocytic Predominance Hodgkinʼs Disease—The Kiel Experience

Cited by 19 publications

References 0 publications

Hodgkin Lymphoma in a Child With Sickle Cell Anemia

Hodgkin Lymphoma in a Child With Sickle Cell Anemia

B-cell development in progressively transformed germinal centers: similarities and differences compared with classical germinal centers and lymphocyte-predominant Hodgkin disease

Clonal identification of Burkitt's Lymphoma Arising from Lymphocyte‐Predominant Hodgkin's Disease

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