Clonal identification of Burkitt's Lymphoma Arising from Lymphocyte‐Predominant Hodgkin's Disease

Abstract

The occurrence of large cell lymphomas subsequent to, or concurrent with, lymphocyte predominant Hodgkin's disease (LPHD) is a well-documented phenomenon. We present a case of Burkitt's lymphoma of the bladder, occurring after the successful treatment of LPHD of a cervical lymph node. To evaluate the clonal relationship of the two tumours, we amplified the complementarity-determining-region 3 of two samples from paraffin-embedded slides, using the polymerase chain reaction (PCR). The sequences of the PCR products showed 96% homology to each other. These results indicate that the malignant clone of Burkitt's lymphoma arose from the corresponding LPHD.

Identification of Common Germinal-Center B-Cell Precursors in Two Patients with Both Hodgkin's Disease and Non-Hodgkin's Lymphoma

“…[24][25][26][27] In the example of classic Hodgkin's disease in which the patient also had a non-Hodgkin's lymphoma, only a single case has been analyzed with molecular techniques. 28 The two lymphomas were clonally unrelated.…”

U‐2940, a human B‐cell line derived from a diffuse large cell lymphoma sequential to Hodgkin lymphoma

“…37 In addition, the molecular data obtained in the few cases of composite HL and NHL analyzed to date showed clonally related IgH rearrangements in both types of neoplastic cells, thus supporting the concept that both neoplasias develop from a single germinal center B cell. [15][16][17]38,39 Attempts to pick up tumor cells by microdissection from paraffin-embedded mediastinal biopsy were made in order to isolate DNA and evaluate the IgH clonal relationship between HRS cells and the pleural effusion/cell line material. Unfortunately, we did not get IgH amplification products from the DNA prepared from the few picked cells.…”

“…14 Finally, the description of other forms of NHL and HL association firmly contributed to the concept that composite HL and NHL may stem from a common precursor and diverge along transformation. [15][16][17] The role of mismatch repair system deficiency in the development or progression of a wide variety of tumors was unraveled over the last few years. 18 Microsatellite instability (MSI), the hallmark of mismatch repair deficiency, is a relatively rare finding in lymphomas.…”

Concomitant Classic Hodgkin Lymphoma of Lymph Node and cMYC-Positive Burkitt Leukemia/Lymphoma of the Bone Marrow Presented Concurrently at the Time of Presentation: A Rare Combination of Discordant Lymphomas

“…EBV is considered a cofactor in the pathogenesis with a very close association between EBV and BL as EBV has been detected in virtually all cases of endemic BL and some cases of sporadic BL. 14 Regarding the association between HL and BL, the only few reported cases so far are therapy-related sequential lymphoma: a case of BL occurring in the same LN after successful treatment of nodular lymphocytes predominant HL (NLPHL) in which derivation form same clone has been proven 15 and another case of HL (nodular sclerosis) developed after treatment of BL was also reported. 16 EBV can immortalize human B-cells and is found in the HRS cells of about 30% of cHL in developed countries.…”