Progressive thrombosis after treatment of diffuse large cell non-hodgkin's lymphoma and concomitant lupus anticoagulant

Keung, Yi‐Kong; Cobos, Everardo; Meyerrose, Gary; Roberson, Glenn H.

doi:10.3109/10428199609051629

Cited by 15 publications

(8 citation statements)

References 13 publications

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“…3,[15][16][17][18][19][20][21] NHL, being a hematological malignancy, has also been found to be associated with APAs as well as an increased risk of thrombosis. [22][23][24] However, the exact prevalence of APAs in NHL and their clinical/prognostic significance remains obscure.…”

Section: Discussionmentioning

confidence: 99%

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

et al. 2020

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Background Antiphospholipid antibodies (APAs) are found quite frequently in patients with non-Hodgkin’s lymphoma (NHL). However, the clinical significance of these antibodies is largely unknown. This study aims to delineate the clinical and prognostic role of APAs in NHL patients. Patients and Methods Consecutive patients of NHL were screened for lupus anticoagulant (LA), IgG/IgM anticardiolipin antibody, and IgG/IgM anti-β2-glycoprotein I at the time of diagnosis. Baseline investigations, staging, and treatment were done as per institutional protocol. Patients were followed up until the last known outpatient visit or death. All were screened at each visit for any thromboembolic event. The association of APA status with baseline NHL characteristics and treatment response was evaluated by univariate analysis. Kaplan–Meier survival analysis was used to compare the final outcome in patients with or without APAs. Patients who were initially APA positive were retested for the corresponding antibody at the end of chemotherapy. Results Twenty-four out of 105 patients (22.8%) were APA positive at diagnosis. The presence of APA was not significantly associated with NHL stage, histology, International Prognostic Index score, activated partial thromboplastin time, or treatment response. The median duration of follow-up was 15 months. Only four patients developed venous thrombosis; none was APA positive. There was no statistically significant difference in overall survival between the two groups (p = 0.471). Patients, who were APA positive initially, tested negative at the end of treatment, irrespective of treatment response. Conclusion APAs are encountered more frequently in NHL patients than in the general population. However, APAs do not correlate with disease severity, thrombosis risk, treatment outcome, or overall survival.

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Section: Discussionmentioning

confidence: 99%

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

et al. 2020

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“…From a total of 70 articles retrieved, 47 were excluded for one of the following reasons: review articles (n ϭ 13), [9][10][11][12][13][14][15][16][17][18][19][20][21] no data about incidence of clinical thrombotic events (n ϭ 13), [22][23][24][25][26][27][28][29][30][31][32][33][34] no distinction of type of cancer (n ϭ 9), [35][36][37][38][39][40][41][42][43] duplicated data (n ϭ 3), [44][45][46] case reports (n ϭ 7), [47][48][49][50][51][52][53] and case-control studies of patients with a first event of deep vein thrombosis (DVT) and subsequent cancer diagnosis (n ϭ 2). 54,55 In addition, studies in which the authors evaluated the incidence of thrombosis after bone marrow transplantation (n ϭ 3) [56][57]…”

Section: Selection Of Articlesmentioning

confidence: 99%

Thrombotic complications in adult patients with lymphoma: a meta-analysis of 29 independent cohorts including 18 018 patients and 1149 events

Caruso

Castelnuovo²,

Meschengieser

et al. 2010

Blood

106

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“…The presence of aCL antibodies has been described in patients with NHL [19][20][21][22]. aCL antibodies are related to NHL, this is supported by the theory indicated that aCL antibodies are produced by the lymphoma cells [23].…”

Section: Introductionmentioning

confidence: 77%

The Clinical Significance of Both IgM and IgG Anticardiolipin Antibodies in Non-Hodgkin’s Lymphoma

Saber¹

2016

J Clin Cell Immunol

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Progressive thrombosis after treatment of diffuse large cell non-hodgkin's lymphoma and concomitant lupus anticoagulant

Cited by 15 publications

References 13 publications

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

Antiphospholipid Antibodies Are Not Associated with Clinical Parameters or Prognostic Outcomes in Patients with Non-Hodgkin's Lymphoma

Thrombotic complications in adult patients with lymphoma: a meta-analysis of 29 independent cohorts including 18 018 patients and 1149 events

The Clinical Significance of Both IgM and IgG Anticardiolipin Antibodies in Non-Hodgkin’s Lymphoma

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