Progressive resistance training improves muscle strength in women with inflammatory bowel disease and quadriceps weakness

Tajiri, Guilherme Jun de Souza; Castro, Claudia Lúcia Barros de; Zaltman, Cyrla

doi:10.1016/j.crohns.2014.09.001

Cited by 20 publications

(49 citation statements)

References 5 publications

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“…Considering our results, this is the first time that chronic resistance exercise has been shown to have a reductive effect on inflammatory parameters and damage scores that were already increased in an animal colitis model. Previously, resistance exercise alleviated the intestinal symptoms of IBD patients when the scores of the IBD Questionnaire were examined . As shown by our study, resistance exercise extenuated tissue damage through the suppression of the inflammatory process and may have beneficial effects on UC to prevent exacerbation periods.…”

Section: Discussionsupporting

confidence: 58%

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Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

Özbeyli

Berberoglu

Özen

et al. 2016

Clin Exp Pharma Physio

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The role of second hand smoke (SHS) exposure on ulcerative colitis is not known. Our aim was to examine the effects of α-lipoic acid (ALA), chronic aerobic (AE) or resistance exercise (RE) on SHS exposed rats with colitis. Sprague-Dawley male rats (150-200 g, n=54) were selected for colitis induction. Among the colitis groups, one group was exposed to SHS (6 d/wk, 4 cigarettes/d) and the other was not. The SHS group was divided into subgroups as follows: sedentary; AE (swimming; 3 d/wk); and RE (climbing with weight; 3 d/wk). After 5 weeks, colitis was induced by intrarectal acetic acid. All groups had subgroups that were given subcutaneously ALA (50 mg/kg per day) or vehicle for 3 days. Following decapitation, colon tissues were sampled to examine malondialdehyde (MDA) and glutathione (GSH) levels, myeloperoxidase (MPO) activity, luminol and lucigenin chemiluminenscence, macroscopic scoring and histologic examination. ANOVA and Student's t-test were used for statistical analysis. The increased macroscopic and microscopic scores, MPO, MDA, luminol and lucigenin measurements in colitis and SHS-colitis groups were decreased via ALA (P<.05-.001). AE declined macroscopic and microscopic scores, MDA, lucigenin compared to colitis and SHS-colitis groups (P<.01-.001). RE reduced microscopic score, MPO, MDA, luminol, lucigenin (P<.05-.001) that were increased with colitis. Decreased GSH levels (P<.01) in the SHS-colitis group approached to control levels when given ALA. According to our results SHS and colitis induction increased inflammatory damage. SHS did not worsen it more than colitis. Our results suggest that ALA, AE or RE might be protective for SHS exposed ulcerative colitis conditions.

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Section: Discussionsupporting

confidence: 58%

“…Previously, resistance exercise alleviated the intestinal symptoms of IBD patients when the scores of the IBD Questionnaire were examined. 24 As shown by our study, resistance exercise extenuated tissue damage through the suppression of the inflammatory process and may have beneficial effects on UC to prevent exacerbation periods.…”

Section: Discussionsupporting

confidence: 54%

Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

Özbeyli

Berberoglu

Özen

et al. 2016

Clin Exp Pharma Physio

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“…In three studies, the patients participated strength training, with two supervised interventions were executed on weightlifting machines [40, 42]. With only one study assessing a disease activity index [40].…”

Section: Resultsmentioning

confidence: 99%

“…Candow and colleagues chose a 12-week intervention on 12 different training machines with constant intensity and number of repetitions [40]. The participants in De Souza Tajiris et al study performed an isolated, progressive training involving only the quadriceps muscle [42]. Both found a significant increase in muscle strength ( p < .05 [40], p < .001 [42]).…”

Section: Resultsmentioning

confidence: 99%

“…The participants in De Souza Tajiris et al study performed an isolated, progressive training involving only the quadriceps muscle [42]. Both found a significant increase in muscle strength ( p < .05 [40], p < .001 [42]). Nevertheless, the progressive training protocol leads to a significant improvement in patients’ HrQoL (IBDQ p < .001 [42]), but failed to decrease the disease activity (HBI) significantly [40].…”

Section: Resultsmentioning

confidence: 99%

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Structured physical activity interventions as a complementary therapy for patients with inflammatory bowel disease – a scoping review and practical implications

et al. 2019

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Background Patients with Inflammatory Bowel Disease (IBD) also suffer from a wide range of additional disorders, which may be caused by the disease, the side effect of the medication, or a lack of physical activity (PA). This results in reduced physical and psychological wellbeing. However, as known from other chronic diseases exercise could be utilized as supportive therapy for IBD patients. Main goals of this article are (a) collecting data of the effects structured physical activity interventions have on validated clinical parameters of IBD and health related symptoms, (b) developing activity recommendations for this clientele. Methods A scoping review was conducted, searching for relevant articles published until May 2018, which investigated the effects of structured exercise interventions in IBD patients. The heterogeneity of the outcomes and the interventions did not support a quantitative synthesis thus, a qualitative discussion of the studies is provided. Results After reviewing 353 records, 13 eligible articles were identified. Five studies investigated aerobic exercise, three studies resistance exercise, three studies mind-body therapies and two studies yoga. The quality of the studies is mixed, and the duration is rather short for exercise interventions. Only few studies assessed validated IBD activity markers or inflammatory biomarkers. Nevertheless, the patients showed an increase in fitness, bone mineral density (BMD), quality of life and a decrease of IBD induced stress and anxiety. No severe adversial events were reported. Conclusion Even though the evidence is limited the application of exercise interventions in IBD patients can be assumed to be safe and beneficial for the patients‘ overall-health, and IBD specific physical and psychosocial symptoms. But there is still a high demand for more thoroughly conducted studies, focussing on important clinical outcome parameters.

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A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease

Gettigan

Allen

Sedaghat

et al. 2023

Int J Colorectal Dis

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Purpose Given the substantial risk of treatment failure in inflammatory bowel disease (IBD), adjuvant therapies may play a role in disease management. We aim to carry out a systematic review to examine the effects of structured exercise on the inflammatory response in patients with IBD. Our secondary aim is to examine the effect of structured exercise programmes on body composition given both an increase in visceral obesity and the presence of sarcopenia have deleterious effects on outcomes in IBD. Methods A systematic review was carried out following the Methodological Expectations of Cochrane Intervention Reviews (MECIR) manual and the Cochrane Handbook for Systematic Reviews of Interventions. Title/Abstract and MeSH Terms were used to search for relevant studies. Results In total, 1516 records were screened for eligibility, and 148 records were reviewed for eligibility, of which 16 were included and a further 7 studies were identified from hand searching references. Four studies included body composition outcomes, and 14 studies reviewed the inflammatory response to exercise. Conclusion Further studies of adequate duration are required to include patients with more active disease to demonstrate an inflammatory response to exercise. Body composition measurements including muscle mass and visceral adiposity may play a key role in response to medical therapy in IBD and should be included as exploratory outcomes in future studies. A meta-analysis was not carried out due to the significant heterogeneity amongst studies.

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Progressive resistance training improves muscle strength in women with inflammatory bowel disease and quadriceps weakness

Cited by 20 publications

References 5 publications

Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

Protective effect of alpha‐lipoic acid, aerobic or resistance exercise from colitis in second hand smoke exposed young rats

Structured physical activity interventions as a complementary therapy for patients with inflammatory bowel disease – a scoping review and practical implications

A systematic review of the effect of structured exercise on inflammation and body composition in inflammatory bowel disease

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