Progressive nodular histiocytosis

Torres, Loyda; Sánchez, Jorge; Rivera, Aníbal; González, Anarda

doi:10.1016/s0190-9622(08)81852-x

Cited by 24 publications

(19 citation statements)

References 7 publications

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“…The lesions seemed to spread in a cranial to caudal fashion, something not previously noted. Unlike other patients in the literature [15,[18][19][20] our patients fortunately did not have large or severely disfi guring facial nodules. They did have involvement of the joint fl exures, which has been uncommon in other reports [5,21].…”

Section: Commentscontrasting

confidence: 63%

Progressive nodular histiocytosis

Hilker

Kovneristy²,

Varga³

et al. 2012

J Deutsche Derma Gesell

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SummaryProgressive nodular histiocytosis (PNH) represents a very rare type of non-Langerhans cell histiocytosis (NLCH). It can be distinguished from other types by the occurrence of yellow to red-brown papules and nodules measuring a few centimeters in size. Histologically the nodules represent spindle-cell xanthogranulomas. We report on two new cases of PNH with novel clinical symptoms. In the first case, the patient had microcytic anemia due to massive iron deposition in the nodules and a progressively worsening limp due to involvement of the soles. The complex therapeutic challenge was effectively managed by successive surgical ablation of all visible lesions. The second patient had epibulbar infiltrates. The clinical variability of PNH leads to considerable overlap with other forms of NLCH.

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Section: Commentscontrasting

confidence: 63%

Progressive nodular histiocytosis

Hilker

Kovneristy²,

Varga³

et al. 2012

J Deutsche Derma Gesell

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“…Clinically, the disease is characterized by the progressive appearance of hundreds of lesions of two different types, namely superficial papules and deep nodules [31][32][33][34][35][36][37][38][39][40][41][42][43] (Fig 3, A).…”

Section: Clinical Findingsmentioning

confidence: 99%

“…34 Sometimes, there is a tendency for lesions to coalesce on the face, producing intense ectropion and a leonine appearance 30,32,36,38 (Fig 3, B).…”

Section: Clinical Findingsmentioning

confidence: 99%

“…Spontaneous regression of lesions has only occasionally been reported. 31,33,36 PNH has been reported in association with systemic disorders in two patients only: one 38 had chronic myeloid leukemia, hypothyroidism, and purine and lipoprotein metabolic changes, the other 42 was a child with precocious puberty, growth hormone deficiency, and a hypothalamic tumor.…”

Section: Course and Prognosismentioning

confidence: 99%

“…81,82 Moreover, a leonine appearance is sometimes seen in PNH. 30,32,36,38 Finally, lepromatous leprosy should be considered and ruled out based on the absence of intracellular bacilli.…”

Section: Differential Diagnosismentioning

confidence: 99%

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Unusual variants of non-Langerhans cell histiocytoses

Caputo¹,

Marzano²,

Passoni³

et al. 2007

Journal of the American Academy of Dermatology

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Histiocytic syndromes represent a large, heterogeneous group of diseases resulting from proliferation of histiocytes. In addition to the classic variants, the subset of non-Langerhans cell histiocytoses comprises rare entities that have more recently been described. These last include both forms that affect only the skin or the skin and mucous membranes, and usually show a benign clinical behavior, and forms involving also internal organs, which may follow an aggressive course. The goal of this review is to outline the clinical, histologic, and ultrastructural features and the course, prognosis, and management of these unusual histiocytic syndromes.

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Histiocytoses

Chu¹

2004

Rook's Textbook of Dermatology

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Progressive nodular histiocytosis

Cited by 24 publications

References 7 publications

Progressive nodular histiocytosis

Progressive nodular histiocytosis

Unusual variants of non-Langerhans cell histiocytoses

Histiocytoses

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