Progressive Muscular Dystrophy in Rabbits as a Result of Chronic Choline Deficiency

Hove, E. L.; Copeland, D. H.

doi:10.1093/jn/53.3.391

Cited by 25 publications

(4 citation statements)

References 6 publications

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“…A previous report indicated that Iberian pigs fed an HFF, choline-sufficient diet develop a systemic choline deficiency [21]. Choline deficiency has been linked to hypermetabolism, weight loss, and improved insulin sensitivity [50,51] and might contribute to muscle atrophy through a decrease in the neurotransmitter, acetylcholine, which can cause deficiencies in neuromuscular transmission and contribute to muscle autophagy [47,49,52,53]. Although we did not measure muscle strength in the present study, an association between NAFLD and muscle weakness has long been recognized in elderly populations who may be experiencing age-related sarcopenia and has recently also been found in pediatric populations [8].…”

Section: Discussionmentioning

confidence: 99%

High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease

et al. 2021

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Non-alcoholic fatty liver disease (NAFLD) is a serious metabolic condition affecting millions of people worldwide. A “Western-style diet” has been shown to induce pediatric NAFLD with the potential disruption of skeletal muscle composition and metabolism. To determine the in vivo effect of a “Western-style diet” on pediatric skeletal muscle fiber type and fuel utilization, 28 juvenile Iberian pigs were fed either a control diet (CON) or a high-fructose, high-fat diet (HFF), with or without probiotic supplementation, for 10 weeks. The HFF diets increased the total triacylglycerol content of muscle tissue but decreased intramyocellular lipid (IMCL) content and the number of type I (slow oxidative) muscle fibers. HFF diets induced autophagy as assessed by LC3I and LC3II, and inflammation, as assessed by IL-1α. No differences in body composition were observed, and there was no change in insulin sensitivity, but HFF diets increased several plasma acylcarnitines and decreased expression of lipid oxidation regulators PGC1α and CPT1, suggesting disruption of skeletal muscle metabolism. Our results show that an HFF diet fed to juvenile Iberian pigs produces a less oxidative skeletal muscle phenotype, similar to a detraining effect, and reduces the capacity to use lipid as fuel, even in the absence of insulin resistance and obesity.

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Section: Discussionmentioning

confidence: 99%

High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease

et al. 2021

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“…Choline is an essential nutrient that is a precursor for the cell membrane components phosphatidylcholine (PC) and sphingomyelin, required for synthesis of the neurotransmitter acetylcholine, and is a source of methyl groups for synthetic reactions ( 1 , 2 ) . The adverse effects of choline deficiency on liver lipid accumulation and muscle dystrophy are well established across species ( 3 , 4 ) . Previous studies have demonstrated that the demand for choline increases significantly during lactation, and that it is required for optimal growth and development of the infant ( 5 , 6 ) .…”

mentioning

confidence: 99%

Choline is required in the diet of lactating dams to maintain maternal immune function

et al. 2015

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Choline demands during lactation are high; however, detailed knowledge is lacking regarding the optimal dietary intake during this critical period. The present study was designed to determine the effects of varying intakes of choline on maternal immune function during lactation. Primiparous Sprague -Dawley rats (n 42) were randomised 24-48 h before birth and fed the following diets for 21 d: choline-devoid (0 g choline/kg diet; D, n 10); 1·0 g choline/kg diet (C1, n 11); 2·5 g choline/kg diet (C2·5, n 10); 6·2 g choline/kg diet (C6, n 11). Splenocytes were isolated and stimulated ex vivo with concanavalin A, lipopolysaccharide (LPS) or CD3/CD28. D and C6 dams had lower final body weight, spleen weight and average pup weight than C1 dams (P, 0·05). There was a linear relationship between free choline concentration in pup stomach contents with maternal dietary choline content (P, 0·001, r 2 0·415). Compared with C1 and C2·5, D spleens had a lower proportion of mature T cells and activated suppressor cells, and this resulted in reduced cytokine production after stimulation (P,0·05). Feeding 6·2 g choline/kg diet resulted in a higher cytokine production after stimulation with CD3/CD28 (P,0·05). Except for a higher IL-6 production after LPS stimulation with cells from the C2·5 dams (P,0·05), there were no differences between the C1 and C2·5 dams. For the first time, we show that feeding lactating mothers a diet free of choline has substantial effects on their immune function and on offspring growth. Additionally, excess dietary choline had adverse effects on maternal and offspring body weight but only minimal effects on maternal immune function.

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“…In dietic hepatosis in pigs, which is caused by a deficiency of certain amino acids in the diet, Obel found waxy degeneration in the skeletal musculature in 60 per cent (25). Similar changes in the skeletal musculature can also be induced experimentally in rabbits if they are placed on a choline-poor diet (26). Different types of avitaminosis can give rise to muscle damage in domestic animals.…”

Section: Pathogenesismentioning

confidence: 88%

Acute Muscular Syndrome in Chronic Alcoholism

Lundmark

Fahlgren

et al. 1962

Journal of Internal Medicine

115

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Progressive Muscular Dystrophy in Rabbits as a Result of Chronic Choline Deficiency

Cited by 25 publications

References 6 publications

High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease

High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease

Choline is required in the diet of lactating dams to maintain maternal immune function

Acute Muscular Syndrome in Chronic Alcoholism

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