Progressive multifocal leukoencephalopathy and magnetic resonance imaging

Levy, Jody D.; Cottingham, Karen L.; Campbell, Robert J.; Moore, Gregory K.; Gyorkey, F.; Ashizawa, Tetsuo; Goldman, Arnold M.

doi:10.1002/ana.410190419

Cited by 35 publications

(9 citation statements)

References 5 publications

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“…The symptoms and signs of PML in patients with other underlying immunodeficiencies are similar to those reported in PML associated with AIDS (2,28–31). The symptoms of PML most commonly include motor weakness (42%), speech abnormalities (40%), cognitive abnormalities (36%), headache (32%), visual field deficits (32%), ataxia (21%), aphasia (17%), cranial nerve deficits (13%) and sensory deficits (9%) (2,28,29,32–37).…”

Section: Discussionsupporting

confidence: 75%

Successful Outcome of Progressive Multifocal Leukoencephalopathy in a Renal Transplant Patient

Crowder

Gyure

Drachenberg

et al. 2005

American Journal of Transplantation

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We report the case of a 47-year-old man who developed progressive multifocal leukoencephalopathy (PML) after receiving immuno-suppressive therapy for renal transplantation. The patient presented with a focal seizure and cognitive changes 5 months posttransplantation. He was found to have enhancing lesions in the parietal lobe and typical findings of PML in a brain biopsy. Immunosuppression was discontinued and the neurological symptoms gradually resolved over a period of 4 weeks. The patient is free of any neurological symptoms 36 months after the diagnosis of PML and imaging studies demonstrate resolution of the PML lesions. The patient returned to hemodialysis 3 months after immunosuppression was discontinued. We also present a review of the literature on PML in renal transplant recipients.

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Section: Discussionsupporting

confidence: 75%

Successful Outcome of Progressive Multifocal Leukoencephalopathy in a Renal Transplant Patient

Crowder

Gyure

Drachenberg

et al. 2005

American Journal of Transplantation

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“…MRI patterns in PML are widely recognised and reveal multifocal lesions of cerebral white matter, with few specific elements [7][8][9]. Accordingly, the diagnosis of PML is based on identification by PCR of viral sequences in the CSF.…”

Section: Discussionmentioning

confidence: 99%

Conventional and diffusion-weighted MRI in progressive multifocal leukoencephalopathy: new elements for identification and follow-up

et al. 2006

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“…As a result of the increased prevalence of PML, many aspects of this disease, including the pathology, clinical characteristics and radiological findings, have become known [19][20][21]. It has been suggested that the JCV circulating in the human population is an archetypal strain that can establish latency in the kidneys [22,23].…”

mentioning

confidence: 99%

Detection of JC Virus Type 1 in Peripheral Lymphocytes, Brain and Cerebrospinal Fluid from Two Korean AIDS Patients with Progressive Multifocal Leukoencephalopathy

Jeong

Jin²,

Choi³

et al. 2002

Intervirology

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The human polyomavirus JC virus (JCV) is the etiologic agent of the fatal demyelinating central nervous system disease progressive multifocal leukoencephalopathy (PML), which occurs in 4–7% of AIDS patients. Two Korean AIDS patients with PML were assayed for JCV, and the virus was genotyped by polymerase chain reaction, DNA sequencing and phylogenetic analysis. Using immunohistochemical analysis, we also examined the distribution of JCV antigen in the brains of the patients. The JCV genome was detected in peripheral lymphocytes, brain and cerebrospinal fluid from these Korean PML patients. Although type 2 is the most common genotype in Asia, the genotype of the JCV in these two AIDS patients was characterized as type 1, which is of European origin. We found that JCV antigen was selectively detected in oligodendrocytes and astrocytes of the brains from these patients. Compared to the prototype type 1 (Mad-1), two different nucleotides (G→C) in the KOR-1 strain identified here were found at positions 2488 and 2490 of the major capsid protein VP1 gene. In summary, this is the first report of PML in Korean AIDS patients; it is also the first isolation of JCV type 1 in PML in East Asians.

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Progressive multifocal leukoencephalopathy and magnetic resonance imaging

Cited by 35 publications

References 5 publications

Successful Outcome of Progressive Multifocal Leukoencephalopathy in a Renal Transplant Patient

Successful Outcome of Progressive Multifocal Leukoencephalopathy in a Renal Transplant Patient

Conventional and diffusion-weighted MRI in progressive multifocal leukoencephalopathy: new elements for identification and follow-up

Detection of JC Virus Type 1 in Peripheral Lymphocytes, Brain and Cerebrospinal Fluid from Two Korean AIDS Patients with Progressive Multifocal Leukoencephalopathy

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