Progressive microvascular injury in liver and colorectal liver metastases following laser induced focal hyperthermia therapy

Abstract

Focal hyperthermia produces both progressive microvascular and tissue damage in liver and colorectal liver metastases. An increase in tissue injury following focal hyperthermia may be a direct result of progressive microvascular damage. Tumor vessels appear more susceptible to direct focal hyperthermia destruction than liver sinusoids. The liver sinusoids are however more susceptible to progressive damage or occlusion following the initial laser thermal stimulus.

Effects of hyperthermia with dextran magnetic fluid on the growth of grafted H22 tumor in mice

“…Eikesdal Their results showed that heat treatment induces damage to the microvessels and tissue immediately, and increases apoptosis in the tissue [16]. After heat treatment, vascular and tissue injury still increase gradually, with vascular injury appearing earlier than tissue injury [9], but apoptosis is stable [16], which is consistent with the tendency that the volume of necrosis in tumor tissue increases with time. Consequently, the temporal decrease of VEGF in the experiment might be caused by necrosis of the vessels and tissue.…”

“…The results in this paper also prove that single magnetic fluid hyperthermia can inhibit the growth of grafted tumors in mice. Data show that local hyperthermia treatment can induce an immunology reaction [5], tissue necrosis [6] and cell apoptosis [7], increase vessel permeability [8,9], and inhibit tumor cell infiltration and migration [10]. In short, it has various effects on tumor growth, but the molecular mechanism of local hyperthermia as well as magnetic fluid hyperthermia still remains uncertain.…”

“…In vivo, hyperthermia increases vessel permeability [8,9]. Therefore, hyperthermia represses angiogenesis to inhibit grafted tumor growth.…”

Conductive Interstitial Thermal Therapy (CITT) Device Evaluation in VX2 Rabbit Model

“…It is likely that the loss of surrounding stroma and vascular supply will result in eventual necrosis of these residual tumor cells. In future work, the ablated tissue will be excised 48 hours post-ablation following Nikfarjam, M. Muralidharan, V. et al, 2005. The histological findings will be compared again to the modeling and temperature measurements.…”

Conductive interstitial thermal therapy device for surgical margin ablation:In vivoverification of a theoretical model

“…The relatively minor differences in predicted ablation depth and actual ablation death may be explained by the time at which tissues were resected and the effect of progressive injury, which isn't taken into consideration in these mathematical models [81]. It has been demonstrated that peak progressive thermal damage occurs, at least in liver models, at 24-72 hours postablation [82,83].…”