Progressive loss of hybrid histidine kinase genes during the evolution of budding yeasts (Saccharomycotina)

Hérivaux, Anaïs; Lavín, José L.; Bernonville, Thomas Dugé de; Vandeputte, Patrick; Bouchara, Jean‐Philippe; Gastebois, Amandine; Oguiza, José A.; Papon, Nicolas

doi:10.1007/s00294-017-0797-1

Cited by 8 publications

(6 citation statements)

References 59 publications

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“…Indeed, wild-type RcsD in E. coli produces low levels of a short phosphotransfer protein (Rogov et al, 2004; Wall et al, 2020). HPt orphan proteins function as phosphate transfer components in multiple phosphorelay systems in numerous prokaryotes and eukaryotes (Herivaux et al, 2018; Kennedy et al, 2016; Mohanan et al, 2017; Valentini et al, 2016), and have evolved from larger phosphotransferase proteins containing multiple domains. The frameshift present in rcsD of Y. pestis may represent an ongoing evolutionary process generating an orphan HPt protein and consequently a new regulatory pathway.…”

Section: Discussionmentioning

confidence: 99%

A frameshift inYersinia pestis rcsDleads to expression of a small HPt variant that alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

Guo

Yan

Yang

et al. 2022

Preprint

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Multiple genetic changes in the enteric pathogen Yersinia pseudotuberculosis have driven the emergence of Yesinia pestis, the arthropod-borne, etiological agent of plague. These include developing the capacity for biofilm-dependent blockage of the flea foregut to enable transmission by flea bite. Previously, we showed that pseudogenisation of rcsA, encoding a component of the Rcs signalling pathway, is an important evolutionary step facilitating Y. pestis flea-borne transmission. Additionally, rcsD, another important gene in the Rcs system, harbours a frameshift mutation. Here, we demonstrated that this rcsD mutation resulted in predominant production of a small protein composing the C-terminal RcsD histidine-phosphotransferase domain (designated RcsD-Hpt) and low levels of full-length RcsD. Genetic analysis revealed that the rcsD frameshift mutation followed the emergence of rcsA pseudogenisation. It further altered the canonical Rcs phosphorylation signal cascade, fine-tuning biofilm production to be conducive with retention of the pgm locus in modern lineages of Y. pestis. Taken together, our findings suggest that a frameshift mutation in rcsD, is an important evolutionary step that fine-tuned biofilm production to ensure perpetuation of flea-mammal plague transmission cycles.

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Section: Discussionmentioning

confidence: 99%

A frameshift inYersinia pestis rcsDleads to expression of a small HPt variant that alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

Guo

Yan

Yang

et al. 2022

Preprint

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“…The majority of fungal response regulators (i.e., proteins with receiver domains and lacking sensor kinase domains) fall within three groups, termed Rim15, Skn7, and Ssk1 after the best-characterized Saccharomyces cerevisiae homologs. A narrow group of fungi closely related to Candida albicans encode Ssr1-type response regulators ( 5 ), and a few unclassified response regulators have been reported ( 7 , 8 ). Thus, fungal receiver domains exist in the context of at least 24 distinct protein architectures.…”

Section: Opinion/hypothesismentioning

confidence: 99%

“…We took advantage of published studies that assigned HHKs to groups ( 3 , 4 , 6 , 7 , 11 , 12 ) and expanded/refined classifications of all HHKs and response regulators encoded by these species as described in Text S1 . Srr1 response regulators from an additional 18 species were also included ( 5 ). Examples of phylogenetic trees used by others to classify fungal HHKs and response regulators are in references 5 , 6 , 7 , and 11 .…”

Section: Opinion/hypothesismentioning

confidence: 99%

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Predicted Functional and Structural Diversity of Receiver Domains in Fungal Two-Component Regulatory Systems

Bourret

Foster

Goldman

2021

mSphere

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“…The first members of this group were characterized at the beginning of the 1990s in yeast (referred to as fungal group VI of HKs) and a few years later in plants (referred to as AHK1) (Table 1). In Saccharomyces cells, these receptors are known to allow the yeast to respond and adapt to osmotic and (to a lesser extent) oxidant stresses 53,76 . In Arabidopsis, the TCS controlled by AHK1 was reported to perceive water stress and to initiate histidine-to-aspartate phosphotransfer circuitry for seed desiccation and vegetative stress tolerances 47, [77][78][79][80][81][82][83][84][85][86][87] .…”

Section: Hks In Eukaryamentioning

confidence: 99%

What do archaeal and eukaryotic histidine kinases sense?

Papon¹,

Stock

2019

F1000Res

Self Cite

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Signal transduction systems configured around a core phosphotransfer step between a histidine kinase and a cognate response regulator protein occur in organisms from all domains of life. These systems, termed two-component systems, constitute the majority of multi-component signaling pathways in Bacteria but are less prevalent in Archaea and Eukarya. The core signaling domains are modular, allowing versatility in configuration of components into single-step phosphotransfer and multi-step phosphorelay pathways, the former being predominant in bacteria and the latter in eukaryotes. Two-component systems regulate key cellular regulatory processes that provide adaptive responses to environmental stimuli and are of interest for the development of antimicrobial therapeutics, biotechnology applications, and biosensor engineering. In bacteria, two-component systems have been found to mediate responses to an extremely broad array of extracellular and intracellular chemical and physical stimuli, whereas in archaea and eukaryotes, the use of two-component systems is more limited. This review summarizes recent advances in exploring the repertoire of sensor histidine kinases in the Archaea and Eukarya domains of life.

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Progressive loss of hybrid histidine kinase genes during the evolution of budding yeasts (Saccharomycotina)

Cited by 8 publications

References 59 publications

A frameshift inYersinia pestis rcsDleads to expression of a small HPt variant that alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

A frameshift inYersinia pestis rcsDleads to expression of a small HPt variant that alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

Predicted Functional and Structural Diversity of Receiver Domains in Fungal Two-Component Regulatory Systems

What do archaeal and eukaryotic histidine kinases sense?

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