Predicted Functional and Structural Diversity of Receiver Domains in Fungal Two-Component Regulatory Systems

Bourret, Robert B.; Foster, Clay A.; Goldman, William E.

doi:10.1128/msphere.00722-21

Cited by 2 publications

(1 citation statement)

References 51 publications

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“…The main difference between the prokaryotic two-component system and the eukaryotic MSP is the HHK containing an additional receiver domain compared to the simpler architecture of the HK from prokaryotes. Additionally, a phosphotransfer protein is working between the HHK and the response regulator, refining but also complicating the signaling process [142] [143]. Kinases phosphorylate proteins by using ATP as a phosphate donor and are named and categorized based on the aa residue they phosphorylate [144] [143].…”

Section: Multistep Phosphorelay Systemsmentioning

confidence: 99%

Molecular Mechanisms of Fungal Signaling

Jacob¹,

Bühring²,

Bersching³

2022

Preprint

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Biochemical signaling is the key mechanism to coordinate a living organism in all aspects of its life. It is still enigmatic how exactly cells and organisms deal with environmental signals and irritations precisely because of the limited number of signaling proteins and a multitude of transitions inside and outside the cell. Many components of signaling pathways are functionally pleiotropic, which means they have several functions. A single stimulus often activates multiple effectors, a distinct effector can be activated by numerous stimuli and signals triggered by different stimuli are often transduced via shared network components. This very compact and concise review sheds light on the most important molecular mechanisms of cellular signaling in fungi.

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Section: Multistep Phosphorelay Systemsmentioning

confidence: 99%

Molecular Mechanisms of Fungal Signaling

Jacob¹,

Bühring²,

Bersching³

2022

Preprint

View full text Add to dashboard Cite

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Recent Advances in Research on Molecular Mechanisms of Fungal Signaling

2022

View full text Add to dashboard Cite

Biochemical signaling is one of the key mechanisms to coordinate a living organism in all aspects of its life. It is still enigmatic how exactly cells and organisms deal with environmental signals and irritations precisely because of the limited number of signaling proteins and a multitude of transitions inside and outside the cell. Many components of signaling pathways are functionally pleiotropic, which means they have several functions. A single stimulus often results in multiple responses, a distinct response can be triggered by numerous stimuli and signals initiated by different stimuli are often transduced via commonly used network components. This review sheds light on the most important molecular mechanisms of cellular signaling in fungi and consequently provides a comprehensive overview about the current state of research on the road to understand the impact of signal transduction in eukaryotic microorganisms.

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Predicted Functional and Structural Diversity of Receiver Domains in Fungal Two-Component Regulatory Systems

Abstract: Fungal two-component regulatory systems incorporate receiver domains into hybrid histidine kinases (HHKs) and response regulators. We constructed a nonredundant database of 670 fungal receiver domain sequences from 51 species sampled from nine fungal phyla.

Cited by 2 publications

References 51 publications

Molecular Mechanisms of Fungal Signaling

Molecular Mechanisms of Fungal Signaling

Recent Advances in Research on Molecular Mechanisms of Fungal Signaling

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