Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential

Szarka, Krisztina; Tar, Ildikó; Fehér, Enikő; Gáll, Tamás; Kis, Andrea; Tóth, Enikő; Boda, Róbert; Márton, Ildikó; Gergely, Lajos

doi:10.1111/j.1399-302x.2009.00516.x

Cited by 75 publications

(76 citation statements)

References 31 publications

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“…Only data generated from primary squamous cell carcinomas (SCC) were extracted, and we excluded reports if: (1) the detection methods were not well-detailed, and/or (2) HPV data could not be extracted per anatomic site. We took care to avoid tallying overlapping patient cohorts [2][3][4][5][6][7][8][9][10][11][12][13]. The final extracted data included: county, year of publication, anatomical site, HPV type, detection method of including primers, and summary of findings for cancers, patient controls, benign lesions, potentially premalignant lesions, and premalignant lesions, when available.…”

Section: Methodsmentioning

confidence: 99%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

224

218

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Perhaps one of the most important developments in head and neck oncology of the past decade is the demonstration that patients with human papillomavirus (HPV)-mediated oropharyngeal cancers have significantly improved outcomes, compared to HPV-negative counterpart patients. This has become the basis for clinical trials investigating the impact on ''treatment deintensification'' for patients with HPV-mediated oropharyngeal cancers. Unfortunately, the significance of HPV in non-oropharyngeal head and neck cancers is much less certain. Our goal is to systematically review the published data regarding the role HPV in carcinomas of the oral cavity, larynx, sinonasal tract and nasopharynx with respect to HPV detection frequency, viral activity, and association with outcome. We also present preliminary data on HPV16/18 transcriptional status in oral cavity carcinomas, as well as salivary gland neoplasia, as determined by nested reverse transcription PCR for HPV E6/E7 RNA. The weighted prevalence (WP) of HPV DNA detection in 4,195 oral cavity cancer patients is 20.2 %, (95 % CI 16.0 %, 25.2 %). HPV16 is the most common type detected. Importantly, no data currently demonstrates a significant association between the presence of HPV DNA and improved outcome. The WP of HPV DNA in 1,712 laryngeal cancer patients is 23.6 %, (95 % CI 18.7 %, 29.3 %). Similarly, no association has yet been demonstrated between HPV DNA status and outcome. The WP of HPV DNA detection in 120 sinonasal cancer patients is 29.6 % (95 % CI 17.8 %, 44.9 %), and in 154 nasopharyngeal carcinoma patients is 31.1 %, (95 % CI 20.3 %, 44.5 %). Recent preliminary data also suggests an association between HPV and certain salivary gland neoplasms. The clinical significance of these findings is unclear. The published data strongly support the need for studies on patients with oral and laryngeal carcinomas that will be powered to find any differences in clinical outcome with respect to HR-HPV and p16 overexpression.

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Section: Methodsmentioning

confidence: 99%

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Isayeva

Maswahu

et al. 2012

Head and Neck Pathol

224

218

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“…Multiple HPV types were present in 17 of 30 (56.7%) specimens and 2 specimens contained HPV-16, -18 and other types. Using real-time PCR analysis, Szarka et al demonstrated that the HPV prevalence increased gradually with the severity of the lesions (32.8, 40.9 and 47.7% in oral lichen planus (OLP), oral leukoplakia (OL) and OSCC, respectively) (Szarka et al, 2009). Similarly, the average HPV copy numbers by the real-time PCR were 5.2 X 10 2 (range: 10-840), 6.8 X 10 3 (range 10-51,000), 7.2 X 10 3 (range 10-27,000) and 2.4 X 10 5 (range 90-130,000) per µg of total DNA in oral controls, OLP, OL and OSCC patients, respectively (18).…”

Section: Enumeration Of Viral Copy Number By Real-time Pcrmentioning

confidence: 99%

Detection of Human Papillomavirus in Normal Oral Cavity in a Group of Pakistani Subjects using Real-Time PCR

Gichki¹,

Buajeeb²,

Doungudomdacha³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…In an Italian study it was estimated that there is a 7.8-times higher risk of HPV in oral premalignant lesions than in normal mucosa (7). A study from Hungary reported 32.8% of HPV-positive OLP lesions (3). Th e same group later reported percentage of HPV-positive OLP to be 19.7% (8).…”

mentioning

confidence: 91%

“…During the last decades, several studies have suggested that human papillomaviruses (HPVs) are involved in the development of premalignant and malignant lesions (2). Th e causal role of HPV has been reported for OLP and oral squamous cell carcinoma, but there are wide variations in disease prevalence with regard to diff erent geographic populations (3). Th e aim of this study was to determine the prevalence of HPV on the mucosa in patients with OLP and compare it with healthy mucosa.…”

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confidence: 99%

The prevalence of human papillomavirus in patients with oral lichen planus and normal oral mucosa

Radochová¹,

L²,

Slezák³

2015

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Oral lichen planus (OLP) is a chronic infl ammatory disorder that aff ects the oral mucous membrane. Th e prevalence of OLP in the population is considered to be 1%-2% (1). Th e etiology of OLP is not known. Th e immune system very probably plays the primary role in the development of this disease. During the last decades, several studies have suggested that human papillomaviruses (HPVs) are involved in the development of premalignant and malignant lesions (2). Th e causal role of HPV has been reported for OLP and oral squamous cell carcinoma, but there are wide variations in disease prevalence with regard to diff erent geographic populations (3). Th e aim of this study was to determine the prevalence of HPV on the mucosa in patients with OLP and compare it with healthy mucosa.Study protocol has been approved by the local ethical committee. Written informed consent was obtained from all subjects entering the study. Patients with OLP were included based upon following criteria: clinically diagnosed OLP according to objective examination (single physician) and histologically confi rmed OLP. OLP was classifi ed according to criteria previously published by World health Organization and modifi ed by van der Meij et al. (4). Smokers and patients with alcohol abuse history were excluded from the study. Sex-and age-matched controls were chosen from individuals undergoing various dental procedures with no known mucosal disease. Native tissue samples were sent for HPV genome detection. HPV DNA was extracted from native tissue. All samples were screened for the presence of HPV DNA by PCR amplifi cation with primers GP5+/ GP6+ located within the HPV L1 gene. Th e sequences of the forward and reverse primers used were FW (GP5+): 5'-TTTGTTACTGTGGTAGATACTAC-3' and REV (GP6+): 5'-AAAAATAAACTGTAAATCATATT-3'. Th is allows the detection of 37 HPV types, specifi cally 6,11,16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 69, 70, 71, 72, 73 (MM9), 81, 82 (MM4), 83 (MM7), 84 (MM8), IS39, and CP6108. HPV typing was performed, however, due to low amounts of DNA it was not possible to analyze the results. Chi-square and Student t-test were used for comparisons. P value <0.05 was considered statistically signifi cant. A total of 45 patients with confi rmed diagnosis of OLP were examined for HPV, of whom, 33 (73.3%) were woman and 12 (26.7%) were men. Th e mean age of the patients was 56 years (±14.96) with an overall range of 33-77 years. Th e control group consisted of 24 individuals, 19 (79.2%) were women and 5 (20.8%) were men. Th e mean age of the individuals in control group was 56.1 years (±11.41) with an overall range of 29-81 years. Th ere was no statistical signifi cance according to age (p = 0.96) and gender (p = 0.59) between OLP patients and controls. Th ere were 24 (53.3%) HPV-positive patients with OLP and 21 (46.7%) patients were HPV-negative. In the control group there were 12 sub-

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Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential

Abstract: HPVs may be involved in the development or progression of not only OSCC but also of potentially malignant oral lesions.

Cited by 75 publications

References 31 publications

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Human Papillomavirus in Non-Oropharyngeal Head and Neck Cancers: A Systematic Literature Review

Detection of Human Papillomavirus in Normal Oral Cavity in a Group of Pakistani Subjects using Real-Time PCR

The prevalence of human papillomavirus in patients with oral lichen planus and normal oral mucosa

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