Progression to dementia in patients with essential tremor

Louis, Elan D.; Radler, Keith; Huey, Edward D.; Cosentino, Stephanie

doi:10.1016/j.parkreldis.2020.12.011

Cited by 6 publications

(3 citation statements)

References 4 publications

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“…This provides a remarkable opportunity for closure, and family members often note that it is a relief to "finish what my father/mother started". As ET is associated with greater cognitive decline and higher rates of conversion to dementia than controls [36,38], it is not surprising that we have observed a response toward brain donation in the families of ET patients paralleling that observed for families of Alzheimer's patients.…”

Section: B Grief Management In Etsupporting

confidence: 67%

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Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor

Iglesias-Hernandez

Berry

Hernández

et al. 2022

Tremor and Other Hyperkinetic Movements

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Brain donation is a challenging process, comprising four sequential stages: (1) the brain donation decision, (2) pre-mortem arrangements and follow up, (3) specimen collection and (4) tissue processing. It is important to understand the factors that are pertinent to each stage. Currently, there is extensive information on factors that involve donor's personal and cultural backgrounds and how these could affect the process. However, little is known about disease-specific factors that influence the process. The Essential Tremor Centralized Brain Repository was established in 2003, and after nearly 20 years of collecting essential tremor (ET) brain tissue, we are well-positioned to discuss the brain donation process from a disease-specific standpoint. In the current manuscript, we discuss ET disease-specific factors that influence the first two stages of the brain donation process. We center our discussion around three points: (1) factors that influence the patient's decision to donate, (2) the involvement of next of kin in the donation, and (3) the rationale for enrolling patients prospectively and evaluating them longitudinally before the anatomical gift takes place. This discussion shares our understanding of the background from which our repository operates and may be of value for other brain banks that study similar neurodegenerative diseases.

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Section: B Grief Management In Etsupporting

confidence: 67%

“…An area of scholarship centers on defining the specific set of manifestations that characterize ET. For example, cognitive decline often accompanies ET, and there is a discussion as to whether it is caused by ET, or merely correlated with it, due to age [ 36 37 38 ]. Action tremor (e.g.…”

Section: Introductionmentioning

confidence: 99%

Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor

Iglesias-Hernandez

Berry

Hernández

et al. 2022

Tremor and Other Hyperkinetic Movements

Self Cite

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“…However, recent evidence has shown that ET is a multidimensional disorder with non-motor (e.g., cognitive) features as well [3]. Indeed, patients with ET appear to have an increased odds or risk of developing mild cognitive impairment (MCI) and dementia [4][5][6][7]. While the characterization of cognitive deficits in ET remains ongoing, surprisingly little is known about the predictors of cognitive impairment and decline in these patients [4,8].…”

Section: Introductionmentioning

confidence: 99%

Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor

Iglesias-Hernandez

Chapman

Radler

et al. 2021

Tremor and Other Hyperkinetic Movements

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Background: Patients with essential tremor (ET) have an increased risk of cognitive impairment, yet little is known about the predictors of cognitive decline in these patients. Exposures to infectious agents throughout the lifespan may impact the later development of cognitive impairment. For example, high Infection exposure has been associated with lower cognitive performance in Alzheimer's and Parkinson's disease. However, this predictor has not been examined in ET.Objectives: To determine whether a higher baseline infection burden is associated with worse cognitive performance at baseline and greater cognitive decline over time in an ET cohort.Method/Design: 160 elderly non-demented ET participants (80.0 ± 9.5 years) underwent an extensive cognitive evaluation at three time points. At baseline, participants completed an infection burden questionnaire (t-IBQ) that elicited information on previous exposure to infectious agents and number of episodes per disease. Analysis of covariance and generalized estimated equations (GEEs) were used.Results: Overall, infection burden was not associated baseline cognitive performance. Adjusted GEE models for repeated measures yielded a significant time interaction between moderate infection burden at baseline and better performance in the attention domain over time (p = 0.013). Previous history of rubella was associated with faster rate of decline in visuospatial performance (p = 0.046). Conclusion:The data were mixed. Moderate self-reported infection burden was associated with better attention performance over time. Self-reported history of rubella infection was related to lower visuospatial performance over time in this cohort. Follow-up studies with additional design elements would be of value.

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Does essential tremor increase risk of cognitive impairment and dementia? Yes

Cosentino

Shih

2022

International Review of Neurobiology

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Progression to dementia in patients with essential tremor

Cited by 6 publications

References 4 publications

Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor

Brain Donation Decisions as Disease Specific Behaviors: An Elucidation of the Donation Process in the Context of Essential Tremor

Baseline Infection Burden and Cognitive Function in Elders with Essential Tremor

Does essential tremor increase risk of cognitive impairment and dementia? Yes

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