Progression of Renal Disease in Patients With Reflux Nephropathy

Abstract

Glomerular damage due to either reflux nephropathy or dysplasia may cause proteinuria. Proteinuria of 100 mg/day was significantly (p < 0.01) associated with 2 SD of glomerular hypertrophy on histology and clinical observation (suggesting hyperfiltration). Thereafter, a rapid increase in proteinuria followed by diastolic hypertension appears be significant for predicting ESRD.

Renal outcome in adults with renal insufficiency and irregular asymmetric kidneys

“…When the eGFR exceeds 40–50 ml/min/1.73 m 2 nephropathy rarely progresses, but disease progression is invariable when function is worse. Nakashima et al similarly reported that an isotopic GFR less than 49 ml/min predicted decline to ESRF [24]. …”

What do we know about chronic renal failure in young adults? II. Adult outcome of pediatric renal disease

“…It is clear from the literature on adults that the development of progressive renal failure in CAKUT is rare unless the GFR is below the range of 40-50 ml/min per 1.73 m 2 [9,[14][15][16]. From the paediatric literature poor outcome has long been associated with high creatinine level and low clearance rate at 1 year [17,18], but there is still a dearth of isotopic GFR data from children which one can correlate with long-term outcome [7].…”

Vesicoureteral reflux and the extracellular matrix connection

“…In severe cases of VUR, recurrent pyelonephritis leads to parenchymal injury and fibrotic scarring of the kidney, known as reflux nephropathy (RN) [6–9]. Congenital reflux nephropathy has also been coined and refers to RN in the context of VUR with a congenital renal malformation, and is often observed in the absence of pyelonephritis.…”