Progression of Crescentic Poststreptococcal Glomerulonephritis to Terminal Uremia Twelve Years after Recovery from an Acute Episode

Tasić, Velibor; Polenakovič, Momir; Cakalarovski, Koco; Kuzmanovska, Dafina

doi:10.1159/000045108

Cited by 6 publications

(3 citation statements)

References 3 publications

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“…Adult nephrologists pointed to unfavorable outcome (11,12) while pediatricians had more optimistic view (4,(13)(14)(15)(16). The long-term prognosis of PSGN is a matter of debate.…”

Section: Discussionmentioning

confidence: 99%

Stress Tolerance Test and SDS-PAGE for the Analysis of Urinary Proteins in Children and Youths

Tasić

Korneti²,

Gucev³

et al. 2001

Clinical Chemistry and Laboratory Medicine

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Excretion of urinary proteins (UP) is an important marker for the evaluation of patients with progressive renal disease. In order to analyze quantitative and qualitative variability of UP in relation to physical activity, we used standardized stress tolerance test and SDS-PAGE. Five urine samples were obtained from each patient at rest, during ordinary daily activity and after physical stress. Determination of total proteins was performed using Meulman's classic method with sulfosalicylic acid. UP were separated by ultrathin horizontal gradient SDS-PAGE according to Görg. There were 142 patients; 40 with poststreptococcal glomerulonephritis (PSGN), 11 with diabetes mellitus, 16 with chronic pyelonephritis and 75 who attended for investigation of asymptomatic proteinuria. Functional proteinuria was established in 42 subjects, who displayed maximal UP excretion during stress and the presence of apolipoprotein AI on SDS-PAGE. Children with PSGN showed no significant increase of UP during stress. Some children with diabetes mellitus (27%) and chronic pyelonephritis (47%) displayed microproteinuria or overt proteinuria after stress. Quantitative and qualitative changes in total UP excretion can be detected by stress tolerance test and SDS-PAGE. It remains to be seen whether stress tolerance test can identify children and youths who are at higher risk for disease progression.

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“…Adult nephrologists pointed to unfavorable outcome (11,12) while pediatricians had more optimistic view (4,(13)(14)(15)(16). The long-term prognosis of PSGN is a matter of debate.…”

Section: Discussionmentioning

confidence: 99%

Stress Tolerance Test and SDS-PAGE for the Analysis of Urinary Proteins in Children and Youths

Tasić

Korneti²,

Gucev³

et al. 2001

Clinical Chemistry and Laboratory Medicine

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“…The disease is caused by group A beta-hemolytic streptococci and usually runs a pretty benign course [1]. Forty to 60 cases of APSGN are admitted at the University Clinic for Children's Disease in Skopje every year, and in one-fourth of the hospitalized children there is evidence of antecedent skin infection.…”

Section: Introductionmentioning

confidence: 99%

Acute poststreptococcal glomerulonephritis following circumcision

Tasić¹,

Polenakovič²

2000

Pediatric Nephrology

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A case of acute poststreptococcal glomerulonephritis following circumcision is presented. An 11-year-old boy was subjected to ritual circumcision, which was complicated by the infection of the wound and development of oliguria, edema, hematuria and hypertensive encephalopathy 2 weeks later. The diagnosis of poststreptococcal glomerulonephritis was established upon the isolation of Streptococcus pyogenes, increased antistreptolysin O (ASTO) and antiDNAse B titers and hypocomplementemia. The clinical course was uneventful with resolution of the nephritic signs, normalization of the complement and clearance of the urinary abnormalities. To the best of our knowledge this is the first case of poststreptococcal glomerulonephritis following infection of the circumcision wound.

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“…He was also a strong proponent of scientific research. He mentored a pediatric doctoral thesis related to the clinical, biological, and prognostic aspects of post-streptococcal glomerulonephritis, from which four articles originated [1][2][3][4]. Velibor Tasic, Zoran Gucev.…”

mentioning

confidence: 99%

In Memoriam Academic Momir Polenakovic, Pediatric Nephrology, Rare Diseases and Publishing in Macedonia

Tasić¹,

Gucev²

2021

Prilozi

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Progression of Crescentic Poststreptococcal Glomerulonephritis to Terminal Uremia Twelve Years after Recovery from an Acute Episode

Cited by 6 publications

References 3 publications

Stress Tolerance Test and SDS-PAGE for the Analysis of Urinary Proteins in Children and Youths

Stress Tolerance Test and SDS-PAGE for the Analysis of Urinary Proteins in Children and Youths

Acute poststreptococcal glomerulonephritis following circumcision

In Memoriam Academic Momir Polenakovic, Pediatric Nephrology, Rare Diseases and Publishing in Macedonia

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