Progress towards understanding the pathogenesis of dengue
hemorrhagic fever

Pang, Xiaowu; Zhang, Rudian; Cheng, Gong

doi:10.1007/s12250-016-3855-9

Cited by 61 publications

(64 citation statements)

References 69 publications

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“…In addition, other flaviviruses have caused numerous epidemics across the globe, as the recent ZIKV outbreaks in Americas and the spread of JEV and WNV into new geographic territories have become serious threats to human health (4,5). It is estimated that over 40% of the world are at the risk of mosquito-borne flavivirus infection, and up to now, no specific antiviral therapy is available for flaviviruses (3,6).…”

Section: Introductionmentioning

confidence: 99%

Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

Qiu

Wang

et al. 2020

Sci. Adv.

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Mosquito-borne flaviviruses infect both mammals and mosquitoes. RNA interference (RNAi) has been demonstrated as an anti-flavivirus mechanism in mosquitoes; however, whether and how flaviviruses induce and antagonize RNAi-mediated antiviral immunity in mammals remains unknown. We show that the nonstructural protein NS2A of dengue virus-2 (DENV2) act as a viral suppressor of RNAi (VSR). When NS2A-mediated RNAi suppression was disabled, the resulting mutant DENV2 induced Dicer-dependent production of abundant DENV2-derived siRNAs in differentiated mammalian cells. VSR-disabled DENV2 showed severe replication defects in mosquito and mammalian cells and in mice that were rescued by RNAi deficiency. Moreover, NS2As of multiple flaviviruses act as VSRs in vitro and during viral infection in both organisms. Overall, our findings demonstrate that antiviral RNAi can be induced by flavivirus, while flavivirus uses NS2A as a bona fide VSR to evade RNAi in mammals and mosquitoes, highlighting the importance of RNAi in flaviviral vector-host life cycles.

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Section: Introductionmentioning

confidence: 99%

Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

Qiu

Wang

et al. 2020

Sci. Adv.

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“…Moreover, Southern Taiwan has experienced a domestic spread of dengue fever over the last 5 years. According to dengue virus type, large spreads occur approximately once every 4 years, and mixed viruses, which result in dengue hemorrhagic fever, can easily occur [40]. This has contributed to a large amount of wasted medical resources and threatened public health.…”

Section: Discussionmentioning

confidence: 99%

Epidemiologic Characteristics of Imported and Domestic Chikungunya Cases in Taiwan: A 13-Year Retrospective Study

Chou

Hsieh

Cheng

et al. 2020

IJERPH

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Background: Chikungunya fever is caused by the chikungunya virus. Numerous factors affect the risk of chikungunya transmission. This study explored the epidemiological characteristics, differences, and trends in domestic and imported cases of chikungunya fever in Taiwan in terms of patient sex, age, month of confirmation, and area of residence from 2007 to 2019. Methods: Public annual chikungunya data from Taiwan’s Centers for Disease Control (CDC) were analyzed. In total, 21 confirmed domestic and 198 imported cases of chikungunya were reported. Of the domestic cases, one was sporadic and reported in July 2019, and 20 were attributed to a cluster event during August and September 2019. Results: In a comparison between domestic and imported cases reported from July to October 2019, differences in sex were nonsignificant (p = 0.555), whereas significant differences were observed for age (p < 0.001), month of confirmation (p = 0.005), and place of residence (p = 0.001). An age of 69–69 years (odds ratio (OR) = 6.66, 95% confidence interval (95%CI) = 2.15–20.65), month of confirmation of September (OR = 5.25, 95%CI = 1.89–14.61) and place of residence of New Taipei City (OR = 48.70, 95%CI = 6.17–384.44) were identified as potential risk factors. Additionally, domestic cases in August and September 2019 increased in proportion to the increase in imported cases during July and August 2019. Increased domestic patients may have been caused by the domestic mosquitoes that transmitted the virus by biting the imported patients to Taiwan. This is the first report comparing domestic and imported cases of chikungunya from surveillance data from the Taiwan CDC from 2007 to 2019. Conclusion: This study highlights the importance of longitudinal and geographically extended studies to understand the implications of zoonotic disease transmission on Taiwan’s population. Critical data were identified to inform future surveillance and research efforts in Taiwan.

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“…Avoiding proper treatment of cases and not recognizing severe cases early are some of the most important factors that affect the increase in the number of cases of severe dengue and fatal cases. [44][45][46] As a result of the large panel of diagnostic tests used, we have been able to report a high proportion of children with asymptomatic infections (40.1%). This is of particular importance because the Colombian surveillance system has reported in recent years that children younger than 14 years is the group with the highest number of cases of dengue, severe dengue, and dengue lethality, 12,15,[47][48][49] and that the subgroup aged 5-9 years are the most affected, similar to what was found in this study.…”

Section: Discussionmentioning

confidence: 99%

Factors Associated with Dengue Virus Infection and Reinfection in Asymptomatic Children in Two Colombian Municipalities

Castro-Bonilla

Coronel-Ruiz

Parra-Álvarez

et al. 2018

The American Journal of Tropical Medicine and Hygiene

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Dengue is the most important arbovirosis in the world. In this study, we assessed the knowledge, attitudes, and practices (KAP) regarding dengue in parents from two small Colombian municipalities in the Cundinamarca Province. Parents and their healthy children from 4 to 14 years of age were included in some public elementary schools. After a medical examination, blood samples were taken for diagnosis of dengue using enzyme-linked immunosorbent assays (capture immunoglobulin M and capture immunoglobulin G [IgG], indirect IgG and detection non-structural viral protein 1) and detection of viral RNA by reverse transcription polymerase chain reaction. In addition, a KAP survey was applied to the children's parents or tutors. The indirect IgG test determined that of the 347 examined children, 87.9% had a previous infection with the dengue virus (DENV), 12.7% of them were positive for viral RNA (asymptomatic infection), and 32.0% presented reinfections. Risk factors evaluation showed that children aged 8 years and older living in the municipalities for more than 7 years were more likely to be infected or reinfected by DENV. In the same way, poor nutrition, lack of water supply, sewer service, or waste disposal services could raise the likelihood of dengue infections. The surveys indicated that parents have unhealthy practices and a low knowledge about the transmission of the disease, which could result in an increase of mosquito breeding sites, allowing sustained dengue transmission.

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Progress towards understanding the pathogenesis of dengue hemorrhagic fever

Cited by 61 publications

References 69 publications

Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

Flavivirus induces and antagonizes antiviral RNA interference in both mammals and mosquitoes

Epidemiologic Characteristics of Imported and Domestic Chikungunya Cases in Taiwan: A 13-Year Retrospective Study

Factors Associated with Dengue Virus Infection and Reinfection in Asymptomatic Children in Two Colombian Municipalities

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