Progress towards a more sustainable synthetic pathway to ibuprofen through the use of solar heating

Abstract

The ACS Green Chemistry Institute Pharmaceutical Roundtable was formed in 2005 to encourage the incorporation of green chemistry techniques into the synthetic pathways of pharmaceuticals. Through this initiative, synthetic pathways of several pharmaceuticals have been altered to adapt more environmentally friendly procedures. The amount of electricity required to complete chemical reactions have become an environmental concern due to depleting fossil fuels. A technique was recently developed in which satellite dishes were repurposed as solar reflectors capable of providing a heat source through solar irradiation. The ability to use the solar reflector as the sole heat source for synthetic reactions has been analyzed for the commercially important pharmaceutical, ibuprofen. Ibuprofen synthesis also incorporates chemicals that are not particularly friendly to the environment. The exchange of these chemicals with more environmentally friendly substitutes has been analyzed. The goal of this study is to incorporate a solar energy heat source to develop an alternative energy, more environmentally friendly pathway to ibuprofen.

Production of Gasolines and Monocyclic Aromatic Hydrocarbons: From Fossil Raw Materials to Green Processes

“…Isobutyl-benzene (IBB) is synthesized by side chain alkylation of toluene with propylene in the presence of alkali metals [46]. It is the starting molecule for producing the common anti-inflammatory drug ibuprofen [47].…”