Progress, Opportunities, and Challenges of Troponin Analysis in the Early Diagnosis of Cardiovascular Diseases

Du, Xuewei; Su, Xujie; Zhang, Wanxue; Yi, Suyan; Zhang, Ge; Jiang, Shan; Li, Hui; Li, Shaoguang; Xia, Fan

doi:10.1021/acs.analchem.1c04476

Cited by 31 publications

(20 citation statements)

References 209 publications

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“…Very recently, we have summarized a critical review on the development of electrochemical biosensors for troponin protein analysis. 493 Very recently, a sensing mechanism based on the inverted molecular pendulum (MP) was developed for the detection of cTnI in different biofluids (Figure 29). 494 The sensing method relies on the target-dependent motion of MP, which generates field-induced transport as a signal readout.…”

Section: Troponin Cardiac Troponin Protein Family Includes Troponin I...mentioning

confidence: 99%

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Zhang

Zhu

et al. 2023

Chem. Rev.

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Whole blood, as one of the most significant biological fluids, provides critical information for health management and disease monitoring. Over the past 10 years, advances in nanotechnology, microfluidics, and biomarker research have spurred the development of powerful miniaturized diagnostic systems for whole blood testing toward the goal of disease monitoring and treatment. Among the techniques employed for whole-blood diagnostics, electrochemical biosensors, as known to be rapid, sensitive, capable of miniaturization, reagentless and washing free, become a class of emerging technology to achieve the target detection specifically and directly in complex media, e.g., whole blood or even in the living body. Here we are aiming to provide a comprehensive review to summarize advances over the past decade in the development of electrochemical sensors for whole blood analysis. Further, we address the remaining challenges and opportunities to integrate electrochemical sensing platforms.

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Section: Troponin Cardiac Troponin Protein Family Includes Troponin I...mentioning

confidence: 99%

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Zhang

Zhu

et al. 2023

Chem. Rev.

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“…50−53 Nanomaterial-based PoCT platforms provide higher sensitivity, low cost, and simple operation for diagnosis. 54,55 Recently, a few review articles have been published and discussed mainly on cardiovascular disease diagnosis from a different perspective, including various types of monitoring technologies, 56 readout techniques, 57 and flexible pressure sensors. 58 Very recently, a nanomaterials-based PoCT method for cardiac biomarkers using the electrochemical readout technique has been published.…”

Section: Introductionmentioning

confidence: 99%

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Vairaperumal,

Huang,

Liu

2023

ACS Appl. Bio Mater.

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Cardiovascular disease is a global health threat, and detecting cardiac biomarkers is essential for early-stage diagnosis and personalized treatment. Traditional approaches have limitations, but optical nanobiosensors offer rapid, highly selective, and sensitive detection. Optical nanobiosensors generate biosignals that transfer light signals while analytes bind with the bioreceptors. Optical nanobiosensors have advantages such as ease of monitoring, low cost, a wide detection range, and high sensitivity without any interference. An optical nanobiosensor platform is a promising approach for point-of-care cardiac biomarker detection with a low detection limit. This review mainly focuses on the detection of cardiovascular disease biomarkers based on various optical nanobiosensor approaches that have been reported during the last five years, and we have categorized them based on optical signal readouts. A detailed discussion of the classification of cardiovascular disease biomarkers, design strategies of optical biosensors, types of optically active nanomaterials, types of bioreceptors, functionalization techniques, various assay types, and sensing mechanisms is presented. Then, we summarize the optical signaling readout-based various nanobiosensors systems for the detection of cardiovascular disease biomarkers. Finally, we summarize and conclude with the recent development of point-of-care testing (PoCT) for cardiovascular disease biomarkers used in various optical readout techniques.

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“…Currently, the number of people affected is rising sharply and the age of onset is significantly decreasing, gradually becoming a major risk to human life and health. 31 Early detection is crucial and many patients are already at an advanced stage by the time of detection, thus missing out on the best time for treatment. It is important to develop a detection method with high specificity and sensitivity.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Acute myocardial infarction (AMI) is the most common cause of death in cardiovascular disease. Currently, the number of people affected is rising sharply and the age of onset is significantly decreasing, gradually becoming a major risk to human life and health . Early detection is crucial and many patients are already at an advanced stage by the time of detection, thus missing out on the best time for treatment.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Electrochemiluminescence of Porphyrin via Crystalline Networks of Metal–Organic Frameworks for Sensitive Detection of Cardiac Troponin I

Zhao

Wang

et al. 2023

Anal. Chem.

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Porphyrins easily aggregate due to unfavorable π-π accumulation, causing luminescent quenching in the aqueous phase and subsequently reducing luminescent efficiency. It is a feasible way to immobilize porphyrin molecules through metal–organic framework materials (MOFs). In this study, 5,10,15,20-tetrakis (4-carboxyphenyl) porphyrin (TCPP) was introduced into the metal–organic skeleton (PCN-224) as a ligand. The result showed that the electrochemiluminescence (ECL) and photoluminescence (PL) efficiency of the MOF skeleton was 8.2 and 6.5 times higher than TCPP, respectively. Impressively, the periodic distribution of porphyrin molecules in the MOF framework can overcome the bottleneck of porphyrin aggregation, resulting in the organic ligand TCPP participating in the electron transfer reaction. Herein, based on the PCN-224, a sandwich-type ECL immunosensor was constructed for the determination of cardiac troponin I (cTnI). It provided sensitive detection of cTnI in the range of 1 fg/mL to 10 ng/mL with a detection limit of 0.34 fg/mL. This work not only innovatively exploited a disaggregation ECL (DIECL) strategy via the crystalline framework of MOF to enhance the PL and ECL efficiency of porphyrin but also provided a promising ECL platform for the ultrasensitive monitoring of cTnI.

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Progress, Opportunities, and Challenges of Troponin Analysis in the Early Diagnosis of Cardiovascular Diseases

Cited by 31 publications

References 209 publications

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Electrochemical Biosensors for Whole Blood Analysis: Recent Progress, Challenges, and Future Perspectives

Optical Nanobiosensor-Based Point-of-Care Testing for Cardiovascular Disease Biomarkers

Enhancing the Electrochemiluminescence of Porphyrin via Crystalline Networks of Metal–Organic Frameworks for Sensitive Detection of Cardiac Troponin I

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