Progress on the Synthesis of Pyrido[1,2-a]benzimidazoles

Abstract

Pyrido[1,benzimidazole is one of the important azaheterocycles with three fused aromatic rings. These molecules containing this skeleton have wide application prospects in the fields of medicinal chemistry and materials, and their syntheses have attracted much attention in organic chemistry. According to the retrosynthetic analysis on the construction of different rings in target molecules, the research progress on the synthesis of pyrido [1,2-a]benzimidazoles from different types of starting materials is reviewed, and its future development direction is prospected.

Application of 2-Aminopyridines in the Synthesis of Five- and Six-Membered Azaheterocycles

“…其实, 更多情况下, 咪唑并[1,2-a]吡啶是由芳基乙 酮类化合物与 2-氨基吡啶在不同的卤代试剂和催化剂 共同作用下同时形成两个 C-N 键而构建的, 并非绝对 需要底物中含有卤源. 一般而言, I 2 常被用作该类反应 的卤源, 因为 I -在卤代烃进行亲核取代反应时易离去, 有利于加速反应进行 [20] .…”