Progress of supercritical fluid technology in polymerization and its applications in biomedical engineering

Tsai, Wen-Chyan; Wang, Yadong

doi:10.1016/j.progpolymsci.2019.101161

Cited by 40 publications

(13 citation statements)

References 149 publications

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“…There is an increasing number of supercritical fluid (SCF) appli cations in diverse industries such as food (Perrut and Perrut, 2019;Brunner, 2005;Ben Nasr and Coenen, 1994;Lehotay, 1997;Kim et al, 1999;Lumia et al, 2007), cosmetics (Temelli, 2009) and biomedical (Masmoudi et al, 2011;Tsai and Wang, 2019). More over, new applications are in development in laboratories (Perrut and Perrut, 2018;Knez et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Determination of mass transfer coefficients in high-pressure two-phase flows in capillaries using Raman spectroscopy

Deleau

Fechter

Letourneau

et al. 2020

Chemical Engineering Science

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Mass transfer of COi into a H20 rich phase at high pressure in a capillary is studied • A rnethod for the determination of volumetric mass transfer coef ficient is presented.• A thermodynami c model and Raman spectroscopy are cou pied to obtain C(h con centrations.• The influen ce of flow rates on the volumetric mass transfer coefficient is studied.• The mass transfer coefficient varies along the length of the micro capillary tube.

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Section: Introductionmentioning

confidence: 99%

Determination of mass transfer coefficients in high-pressure two-phase flows in capillaries using Raman spectroscopy

Deleau

Fechter

Letourneau

et al. 2020

Chemical Engineering Science

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“…(c) Another way of making bio material (3-D scaffolds) for tissue engineering without using solvents is Super critical fluid (SFC) as represented in Figure 5 . The advantage of using supercritical fluid is its control over architectural activities of internal porosity, elimination of solvent, and mimicking the growth of bioactive material at the surface [ 52 ]. The coexistence of liquid and gas makes it an exclusive method as compared to other methods that exist in either liquid or gas form at normal temperature and pressure.…”

Section: Poly Lactic Acid and Its Synthesismentioning

confidence: 99%

Promising Role of Polylactic Acid as an Ingenious Biomaterial in Scaffolds, Drug Delivery, Tissue Engineering, and Medical Implants: Research Developments, and Prospective Applications

et al. 2023

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In the present scenario, the research is now being focused on the naturally occurring polymers that can gradually replace the existing synthetic polymers for the development of bio composites having applications in medical surgeries and human implants. With promising mechanical properties and bio compatibility with human tissues, poly lactic acid (PLA) is now being viewed as a future bio material. In order to examine the applicability of PLA in human implants, the current article sheds light on the synthesis of PLA and its various copolymers used to alter its physical and mechanical properties. In the latter half, various processes used for the fabrication of biomaterials are discussed in detail. Finally, biomaterials that are currently in use in the field of biomedical (Scaffolding, drug delivery, tissue engineering, medical implants, derma, cosmetics, medical surgeries, and human implants) are represented with respective advantages in the sphere of biomaterials.

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“…The ScCO 2 solvent can be an alternative way to ease the mass transfer between reactants under low-temperature conditions, and retain the valuable groups of monomers during the polymerization process. It can be wholly separated from the final product by pressure relief at the end of the reaction without the greenhouse effect, and can be used repeatedly by compression without corrosiveness [ 175 ]. Owing to the abovementioned, it can be said that ScCO 2 is a promising new technology for various chemical reactions, but the development of pressurization devices and the safety of reaction equipment must be in consideration before it can be widely used to produce polymer in an industrial scale.…”

Section: Solvent System For Enzyme-catalyzed Synthesis Of Polyestersmentioning

confidence: 99%

Recent Advances in the Enzymatic Synthesis of Polyester

Wang

Liu²,

Lee

et al. 2022

Polymers

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Polyester is a kind of polymer composed of ester bond-linked polybasic acids and polyol. This type of polymer has a wide range of applications in various industries, such as automotive, furniture, coatings, packaging, and biomedical. The traditional process of synthesizing polyester mainly uses metal catalyst polymerization under high-temperature. This condition may have problems with metal residue and undesired side reactions. As an alternative, enzyme-catalyzed polymerization is evolving rapidly due to the metal-free residue, satisfactory biocompatibility, and mild reaction conditions. This article presented the reaction modes of enzyme-catalyzed ring-opening polymerization and enzyme-catalyzed polycondensation and their combinations, respectively. In addition, the article also summarized how lipase-catalyzed the polymerization of polyester, which includes (i) the distinctive features of lipase, (ⅱ) the lipase-catalyzed polymerization and its mechanism, and (ⅲ) the lipase stability under organic solvent and high-temperature conditions. In addition, this article also focused on the advantages and disadvantages of enzyme-catalyzed polyester synthesis under different solvent systems, including organic solvent systems, solvent-free systems, and green solvent systems. The challenges of enzyme optimization and process equipment innovation for further industrialization of enzyme-catalyzed polyester synthesis were also discussed in this article.

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Progress of supercritical fluid technology in polymerization and its applications in biomedical engineering

Cited by 40 publications

References 149 publications

Determination of mass transfer coefficients in high-pressure two-phase flows in capillaries using Raman spectroscopy

Determination of mass transfer coefficients in high-pressure two-phase flows in capillaries using Raman spectroscopy

Promising Role of Polylactic Acid as an Ingenious Biomaterial in Scaffolds, Drug Delivery, Tissue Engineering, and Medical Implants: Research Developments, and Prospective Applications

Recent Advances in the Enzymatic Synthesis of Polyester

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