Progress of research on the role of active ingredients of Citri Reticulatae Pericarpium in liver injury

17β-Estradiol protects female rats from bilateral oophorectomy-induced nonalcoholic fatty liver disease induced by improving linoleic acid metabolism alteration and gut microbiota disturbance

“…The interaction between liver disease and gut dysbiosis is a concern in both basic and clinical research [ 24 ]. Recent studies on the NAFLD-related gut microbiota changes have focused primarily on plant compounds, pharmaceutical ingredients or probiotics and prebiotics that may potentially reverse liver steatosis, such as CM3-SII polysaccharide [ 25 ], flavonoids contained in Citri Reticulatae Pericarpium [ 26 ], fucoxanthin [ 27 ], flaxseed [ 28 ], phytosterols [ 29 ], isoquercetin [ 30 ], NUTRIOSE® soluble fiber [ 31 ]. The gut microbiota shows distinct diversity in subjects of reproductive age but is not so different after menopause between males and females [ 32 ].…”

Identification and Characterization of Glycosyltransferases Involved in the Biosynthesis of Neodiosmin

“…Flavonoid-7- O -disaccharides are recognized for their diverse biological activities. For example, hesperidin, naringin, diosmin, and neodiosmin have demonstrated various health benefits, including the treatment of alcoholic liver disease, prevention of osteoporosis, osteoarthritis, and diabetes, among other diseases. − Although glycosyltransferases for biosynthesis of flavonoid disaccharides have been reported in many plants, such as Arabidopsis and citrus, inadequate information is available regarding the synthesis of specialized flavone disaccharides, such as neodiosmin.…”