Progress of intravoxel incoherent motion diffusion-weighted imaging in liver diseases

Tao, Yun-Yun; Zhou, Yi; Wang, Ran; Gong, Xue-Qin; Zheng, Jing; Yang, Cui; Yang, Lin; Zhang, Xiaoming

doi:10.12998/wjcc.v8.i15.3164

Cited by 13 publications

(10 citation statements)

References 100 publications

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“…Intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) diffusion imaging is one of the most popular functional MRI imaging techniques in recent years [ 10 ]. The diffusion coefficient of continuous distribution of micro motion in voxel is assumed to be two parts, namely D (diffusion coefficient) and D * (pseudo-diffusion coefficient), which represent slow and fast diffusion, respectively.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of gliomas peritumoral diffusion and prediction of IDH1 mutation by IVIM-DWI

Yang

Huang

et al. 2021

Aging

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Glioma characterized by high morbidity and mortality, is one of the most common brain tumors. The application of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in differentiating glioma grading and IDH1 mutation status were poorly investigated. 78 glioma patients confirmed by pathological and imaging methods were enrolled. Glioma patients were measured using IVIM-DWI, then related parameters such as cerebral blood flow (CBF), perfusion fraction (f), pseudo diffusivity (D*), and true diffusivity (D), were derived. Receiver operating characteristic (ROC) curves were made to calculate specificity and sensitivity. The values of CBF1, CBF3, D*1, rCBF1-2, rCBF3-2, and age in group high-grade gliomas (HGG) were significantly higher than that of in group low-grade gliomas (LGG). The values of CBF1, CBF3, rCBF1-2, rCBF3-2, D*1, and age in group IDH1 mut were significantly lower than that of in group IDH1 wt . The levels of D1 and f1 were remarkably higher in the group IDH1 mut than group IDH1 wt . rCBF1-2 had a remarkably positive correlation with CBF1 (r=0.852, p<0.001). f1 showed a markedly negative correlation with CBF1 (r= -0.306, p=0.007). IVIM-DWI presented efficacy in differentiating glioma grading and IDH1 mutation status.

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Section: Introductionmentioning

confidence: 99%

Evaluation of gliomas peritumoral diffusion and prediction of IDH1 mutation by IVIM-DWI

Yang

Huang

et al. 2021

Aging

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“…In that study, after transarterial chemoembolization was done for HCCs, the ADC and D values of the tumors significantly increased; the D * value decreased significantly, and the PF value did not change significantly. The reason for the inconsistent changes in D * and PF values may be that they represent different aspects of perfusion [ 37 ]. The former is mainly related to the capillary velocity of local tissues, while the latter is related to the blood volume of local tissues [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…The reason for the inconsistent changes in D * and PF values may be that they represent different aspects of perfusion [ 37 ]. The former is mainly related to the capillary velocity of local tissues, while the latter is related to the blood volume of local tissues [ 37 ]. In addition, IVIM does not only reflect blood microcirculation because it is sensitive to any fluid flow, not only blood, as long as there is an intravoxel distribution [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

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Early response evaluation of doxorubicin-nanoparticle-microbubble therapy in orthotopic hepatocellular carcinoma rat model using contrast-enhanced ultrasound and intravoxel incoherent motion-diffusion MRI

Yang

Lee

Moon³

et al. 2022

Ultrasonography

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To apply doxorubicin-loaded nanoparticle microbubble (Dox-NP-MB) therapy in an orthotopic rat model of hepatocellular carcinoma (HCC) and investigate the utility of contrast-enhanced ultrasound (CEUS) and intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM-DWI) in response evaluation. Methods: Twenty-eight N1S1 HCC model rats were treated with either Dox-NP-MB (Group [G] 1 [n=8]); doxorubicin (Dox) alone (G2, [n=7]); nanoparticle microbubbles (NP-MB) alone (G3, [n=7]; or saline (G4, control, [n=6]) on days 0 and 7 with sacrifice on day 11. IVIM-DWI and CEUS were performed before each treatment and before euthanasia. Efficacy was estimated by the percentage of tumor volume growth inhibition compared with control. Toxicity was assessed by body weight changes and blood tests. Post-treatment changes in IVIM-DWI and CEUS parameters were analyzed. Results: Tumor volume growth was inhibited by 48.4% and 90.2% in G1 and G2 compared to G4, respectively. Compared to G2, G1 had a significantly lower degree of body weight change (91.0% [88.5-97.0] vs. 88.0% [82.5-88.8], p <0.05) and leukopenia (1.75 × 10 3 cells/uL [1.53-2.77] vs. 1.20 × 10 3 cells/uL [0.89-1.51], p <0.05). After the first treatment, an increase in peak enhancement, wash-in rate, and wash-in perfusion index on CEUS was observed in G3 and G4 but suppressed in G1 and G2; apparent diffusion coefficients (ADC), true diffusion coefficients (D), and perfusion fractions (PF) significantly increased in G1 and G2 compared to baseline (p <0.05). Conclusion:Dox-NP-MB showed reduced Dox toxicity. Early changes in some CEUS and IVIM-DWI parameters correlated with therapeutic response.

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“…Wu et al performed a metaanalysis evaluating the IVIM model in differentiating focal liver lesions, also including HCC [78]. Tao et al performed a review on the role of IVIM in liver diseases, summarizing also its role in HCC [92]. Notably, Granata et al performed a review specific on HCC, including both IVIM and DKI, but the study was non-systematic and the role of SE model was not discussed [32].…”

Section: Discussionmentioning

confidence: 99%

The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review

Tramontano

Cavaliere

Salvatore

et al. 2021

JCM

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The importance of Diffusion Weighted Imaging (DWI) in hepatocellular carcinoma (HCC) has been widely handled in the literature. Due to the mono-exponential model limitations, several studies recently investigated the role of non-Gaussian DWI models in HCC. However, their results are variable and inconsistent. Therefore, the aim of this systematic review is to summarize current knowledge on non-Gaussian DWI techniques in HCC. A systematic search of the literature, including PubMed, Google Scholar, MEDLINE, and ScienceDirect databases, was performed to identify original articles since 2010 that evaluated the role of non-Gaussian DWI models for HCC diagnosis, grading, response to treatment, and prognosis. Studies were grouped and summarized according to the non-Gaussian DWI models investigated. We focused on the most used non-Gaussian DWI models (Intravoxel Incoherent Motion (IVIM), Diffusion Kurtosis Imaging (DKI), and Stretched Exponential—SE). The quality of included studies was evaluated by using QUADAS-2 and QUIPS tools. Forty-three articles were included, with IVIM and DKI being the most investigated models. Although the role of non-Gaussian DWI models in clinical settings has not fully been established, our findings showed that their parameters may potentially play a role in HCC. Further studies are required to identify a standardized DWI acquisition protocol for HCC diagnosis, grading, response to treatment, and prognosis.

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Progress of intravoxel incoherent motion diffusion-weighted imaging in liver diseases

Cited by 13 publications

References 100 publications

Evaluation of gliomas peritumoral diffusion and prediction of IDH1 mutation by IVIM-DWI

Evaluation of gliomas peritumoral diffusion and prediction of IDH1 mutation by IVIM-DWI

Early response evaluation of doxorubicin-nanoparticle-microbubble therapy in orthotopic hepatocellular carcinoma rat model using contrast-enhanced ultrasound and intravoxel incoherent motion-diffusion MRI

The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review

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