Progress of crystallization in microfluidic devices

Shi, Huanhuan; Xiao, Yan; Ferguson, Steven; Huang, Xin; Wang, Na; Hao, Hongxun

doi:10.1039/c6lc01225f

Cited by 68 publications

(53 citation statements)

References 190 publications

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“…deeper understanding of the nucleation process-as well as on the pharmaceuticals industry-e.g. reduction of time needed for the development of novel drugs by al-lowing early-stage screening of minimal amounts of crystals and co-crystals (Shi et al, 2017) Microfluidics is still a rapidly developing field of research. The interest has slowly been shifting from the methods for droplet production or manipulation to the development of new applications of already known droplet microfluidic techniques and systems that now allow for high-throughput investigation on biological and chemical processes.…”

Section: Discussionmentioning

confidence: 99%

“…As the nucleation process is stochastic, various forms can nucleate in neighboring droplets. With no competition from other nuclei, even highly unstable forms can persist and grow inside the droplet, yielding mononuclear crystals (Shi et al, 2017). Hence, droplet microf luidics allows, e.g.…”

Section: Crystallization In Dropletsmentioning

confidence: 99%

“…grams of proteins (Dolega et al, 2012), and the control of the kinetic pathways in a phase diagram, and that give insight into nucleation and growth processes (Leng and Salmon, 2009;Shi et al, 2017). Detection systems could be coupled with droplet microfluidic devices for monitoring the course of crystallization reactions, e.g.…”

Section: Crystallization In Dropletsmentioning

confidence: 99%

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Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

Opalski

Kamiński

Garstecki

2019

KONA

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Emulsion-a liquid dispersed in another liquid-is in many respects very similar to granular matter. In the early 2000s a new technology-droplet microfluidics-began emerging from the wider field of microfluidics. Droplet microfluidics was quickly established as a discipline of science and engineering and has been used for the generation of highly uniform emulsions. The last few years have brought significant advances to the field, directed towards a wide range of applications in material sciences-from synthesis of nanoparticles in droplets to assembling complex droplets and using droplets as templates for ordered materials, with applications in food, cosmetic and diagnostic industries. Droplet microfluidic platforms are also successfully used as analytical tools in molecular biology and biochemistry, in e.g. high-throughput screening, digital assays, encapsulation of single cells, sequencing technologies, and in point-of-care diagnostic applications. This article provides an accessible overview of the physical phenomena observed in multiphase flow at the microscale and the techniques in droplet microfluidics systems. We also present the most interesting applications and potential further directions of research in this fascinating young field of science and engineering.

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Section: Discussionmentioning

confidence: 99%

Section: Crystallization In Dropletsmentioning

confidence: 99%

Section: Crystallization In Dropletsmentioning

confidence: 99%

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Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

Opalski

Kamiński

Garstecki

2019

KONA

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“…The rapid development of micro‐ and nanofabrication techniques have largely contributed to the revolution of microfluidic device, and previous reviews have summarized primary methods for design of microfluidic device in detail . Two dominant types of microfluidic chips were used in generating various types of NMs . One is glass capillary microfluidic chip that has advantages of high chemical resistance and ideal coaxial construction.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Generation of Nanomaterials for Biomedical Applications

Zhao

Bian

Sun

et al. 2019

Small

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As nanomaterials (NMs) possess attractive physicochemical properties that are strongly related to their specific sizes and morphologies, they are becoming one of the most desirable components in the fields of drug delivery, biosensing, bioimaging, and tissue engineering. By choosing an appropriate methodology that allows for accurate control over the reaction conditions, not only can NMs with high quality and rapid production rate be generated, but also designing composite and efficient products for therapy and diagnosis in nanomedicine can be realized. Recent evidence implies that microfluidic technology offers a promising platform for the synthesis of NMs by easy manipulation of fluids in microscale channels. In this Review, a comprehensive set of developments in the field of microfluidics for generating two main classes of NMs, including nanoparticles and nanofibers, and their various potentials in biomedical applications are summarized. Furthermore, the major challenges in this area and opinions on its future developments are proposed.

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“…emulsion crystallization processes [1] [2], flashcrystallization [3]). A powerful method to investigate crystallization phenomena in discrete volumes is microfluidics [4]. Microfluidics, for example, has been widely used in the field of protein crystallization [5]- [12].…”

Section: Introductionmentioning

confidence: 99%

A Generic Polycarbonate Based Microfluidic Tool to Study Crystal Nucleation in Microdroplets

Selzer¹,

Spiegel²,

Kind³

2018

JCPT

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Crystal nucleation is important to control the product properties in industrial crystallization processes. To investigate crystallization phenomena, methods which rely on microscopic volumes have gained relevance over the last decade. Microfluidic devices are suitable for carrying out crystallization experiments based on a large set of individual droplets in the nanoliter range. In this work, we propose a simple method to manufacture such devices from polycarbonate as an alternative to conventional chips made of poly (dimethylsiloxane). The microfluidic device consists of two main functional parts: A T-junction for droplet generation and a section for storage and observation of up to 400 individual droplets. Using these manufactured devices, it is easy to produce and store highly monodisperse droplets of substances that require either a hydrophilic or hydrophobic surface of the microchannel. Since crystal nucleation is a stochastic process which depends on the sample volume, a reproducible droplet volume is of great importance for crystallization experiments. The versatile applicability of the manufactured devices is demonstrated for substances which are used in different crystallization applications, for example, solution crystallization (aqueous potassium nitrate solution) and melt crystallization (ethylene glycol distearate). Finally, we demonstrate that the manufactured microfluidic devices in our experimental setup can be used to conduct crystal nucleation measurements. Based on these measurements we discuss our results with respect to state-of-the-art nucleation models.

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Progress of crystallization in microfluidic devices

Cited by 68 publications

References 190 publications

Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions

Microfluidic Generation of Nanomaterials for Biomedical Applications

A Generic Polycarbonate Based Microfluidic Tool to Study Crystal Nucleation in Microdroplets

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