Progress in the preparation and evaluation of glucose-sensitive microneedle systems and their blood glucose regulation

Yu, Wei; Yu, Haojie; Wang, Li; Hu, Jintao; Feng, Jingyi

doi:10.1039/d3bm00463e

Cited by 6 publications

(6 citation statements)

References 145 publications

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“…Additionally, modification of the structure of PBA can be employed to enhance its glucose sensitivity [43]. Furthermore, there is also concern about drug inactivation during the preparation and loading processes of phenylboronic-acid-based smart microneedles, necessitating the selection of relatively gentle preparation and storage conditions [35].…”

Section: Glucose-sensitive Microneedles Based On Pbamentioning

confidence: 99%

Smart Responsive Microneedles for Controlled Drug Delivery

Qi,

Yan,

Tan

et al. 2023

Molecules

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As an emerging technology, microneedles offer advantages such as painless administration, good biocompatibility, and ease of self-administration, so as to effectively treat various diseases, such as diabetes, wound repair, tumor treatment and so on. How to regulate the release behavior of loaded drugs in polymer microneedles is the core element of transdermal drug delivery. As an emerging on-demand drug-delivery technology, intelligent responsive microneedles can achieve local accurate release of drugs according to external stimuli or internal physiological environment changes. This review focuses on the research efforts in smart responsive polymer microneedles at home and abroad in recent years. It summarizes the response mechanisms based on various stimuli and their respective application scenarios. Utilizing innovative, responsive microneedle systems offers a convenient and precise targeted drug delivery method, holding significant research implications in transdermal drug administration. Safety and efficacy will remain the key areas of continuous efforts for research scholars in the future.

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Section: Glucose-sensitive Microneedles Based On Pbamentioning

confidence: 99%

Smart Responsive Microneedles for Controlled Drug Delivery

Qi,

Yan,

Tan

et al. 2023

Molecules

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“…“Closed-loop” systems that integrate glucose-binding protein (GBP), 18,19 phenylboronic acid (PBA), 20,21 or glucose oxidase (GOx), 22–24 which have different glucose-sensitive moieties to respond to glycemia continuously, have been developed. PBA-based polymers can form dynamic borate ester bonds with glucose under hypoglycemic conditions, degrading the polymer structure.…”

Section: Introductionmentioning

confidence: 99%

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Ma,

Wang,

et al. 2024

Biomater. Sci.

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“…Diabetes is one of the major public health challenges nowadays, threatening more than 537 million people worldwide . Blood-glucose monitoring and regulating technologies have received sustained attention from the academia and industry. − Recently, scientists tried to design noninvasive/microinvasive systems (e.g. smart contact lens, microneedles) for long-term blood-glucose monitoring.…”

Section: Introductionmentioning

confidence: 99%

Electrostatic-Interaction-Aided Microneedle Patch for Enhanced Glucose-Responsive Insulin Delivery and Three-Meal-Per-Day Blood-Glucose Regulation

Shen,

Yu,

Wang

et al. 2024

ACS Appl. Mater. Interfaces

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The phenylborate-ester-cross-linked hydrogel microneedle patch (MNP) was promising in the diabetic field for the glucose-responsive insulindelivering property and simple fabrication process. However, the unfit design of the charging microneedle network limited the improvement of blood-glucose regulating performances. In this work, insulin-loaded phenylborate-ester-crosslinked MNPs, with the polyzwitterion property, were constructed based on the modified ε-polylysine and poly(vinyl alcohol). The relationship between the charging nature of the MNP network and insulin release was verified by regulating the content of postprotonated positively charged amino groups. The elaborately designed MNP possessed improved glucose-responsive insulindelivering performance. The in vivo study revealed the satisfactory results on blood-glucose regulation by the optimized MNP under the mimic three-mealper-day mode. Moreover, the insulin bioactivity in the MNP could be maintained for 2 weeks under 25 °C. In summary, this work developed an effective strategy to improve the glucose-responsive phenylborateester-cross-linked MNP and enhance its potential for clinical transformation.

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Progress in the preparation and evaluation of glucose-sensitive microneedle systems and their blood glucose regulation

Abstract: Glucose-sensitive microneedle system (GSMS) as a smart strategy to treat diabetes can regulate insulin release according to the blood glucose concentration.

Cited by 6 publications

References 145 publications

Smart Responsive Microneedles for Controlled Drug Delivery

Smart Responsive Microneedles for Controlled Drug Delivery

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy

Electrostatic-Interaction-Aided Microneedle Patch for Enhanced Glucose-Responsive Insulin Delivery and Three-Meal-Per-Day Blood-Glucose Regulation

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