Progress in the field of noninvasive diagnostics for colorectal cancer: a systematic review for the accuracy of blood-based biomarkers for detection of advanced pre-cancerous lesions
“…One major factor contributing to rapid growth of cancer incidence and mortality worldwide is aging and growth of the population. Indeed, a recent analysis predicts a continued rise in cancer incidence in the next decades across all economies [ 24 ], despite significant efforts to promote early diagnosis tools [ 25 ] and develop cancer vaccines [ 26 ]. Fig.…”
Cancer research has played a pivotal role in improving patient outcomes. However, despite the significant investment in fundamental cancer research over the past few decades, the translation of funding into substantial advancements in cancer treatment has been limited. This perspective article employs a detailed analysis to outline strategies for promoting innovation and facilitating discoveries within the field of cancer research.
“…One major factor contributing to rapid growth of cancer incidence and mortality worldwide is aging and growth of the population. Indeed, a recent analysis predicts a continued rise in cancer incidence in the next decades across all economies [ 24 ], despite significant efforts to promote early diagnosis tools [ 25 ] and develop cancer vaccines [ 26 ]. Fig.…”
Cancer research has played a pivotal role in improving patient outcomes. However, despite the significant investment in fundamental cancer research over the past few decades, the translation of funding into substantial advancements in cancer treatment has been limited. This perspective article employs a detailed analysis to outline strategies for promoting innovation and facilitating discoveries within the field of cancer research.
Volatile organic compounds have drawn significant attention in recent years as a novel tool for non-invasive detection of a wide range of diseases, including gastrointestinal cancers, for which the need for effective, affordable, and non-invasive screening methods is substantial. Sample preparation is a fundamental step that greatly influences the quality of results and the feasibility of wide-range applications. This review summarizes sampling methods used in studies aiming at testing the diagnostic value of volatile organic compounds in gastrointestinal cancers, discussing in detail some of the recent advancements in automated sampling techniques. Finally, we propose some directions in which sample collection and processing can improve for VOC analysis to be popularized in clinical settings.
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