Redefining cancer research for therapeutic breakthroughs

Yuzhalin, Arseniy E.

doi:10.1038/s41416-024-02634-6

Br J Cancer

2024

DOI: 10.1038/s41416-024-02634-6

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Redefining cancer research for therapeutic breakthroughs

Arseniy E. Yuzhalin

Abstract: Cancer research has played a pivotal role in improving patient outcomes. However, despite the significant investment in fundamental cancer research over the past few decades, the translation of funding into substantial advancements in cancer treatment has been limited. This perspective article employs a detailed analysis to outline strategies for promoting innovation and facilitating discoveries within the field of cancer research.

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Cooray

2024

Br J Cancer

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Cooray

2024

Br J Cancer

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Principal Bioactive Properties of Oleanolic Acid, Its Derivatives, and Analogues

Jannus,

Sainz,

Reyes-Zurita

2024

Molecules

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Natural products have always played an important role in pharmacotherapy, helping to control pathophysiological processes associated with human disease. Thus, natural products such as oleanolic acid (OA), a pentacyclic triterpene that has demonstrated important activities in several disease models, are in high demand. The relevant properties of this compound have motivated re-searchers to search for new analogues and derivatives using the OA as a scaffold to which new functional groups have been added or modifications have been realized. OA and its derivatives have been shown to be effective in the treatment of inflammatory processes, triggered by chronic diseases or bacterial and viral infections. OA and its derivatives have also been found to be effective in diabetic disorders, a group of common endocrine diseases characterized by hyperglycemia that can affect several organs, including the liver and brain. This group of compounds has been reported to exhibit significant bioactivity against cancer processes in vitro and in vivo. In this review, we summarize the bioactive properties of OA and its derivatives as anti-inflammatory, anti-bacterial, antiviral, anti-diabetic, hepatoprotective, neuroprotective, and anticancer agents.

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Overcoming Cancer Drug Resistance with Nanoparticle Strategies for Key Protein Inhibition

Yoo,

Kim,

Kim

et al. 2024

Molecules

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Drug resistance remains a critical barrier in cancer therapy, diminishing the effectiveness of chemotherapeutic, targeted, and immunotherapeutic agents. Overexpression of proteins such as B-cell lymphoma 2 (Bcl-2), inhibitor of apoptosis proteins (IAPs), protein kinase B (Akt), and P-glycoprotein (P-gp) in various cancers leads to resistance by inhibiting apoptosis, enhancing cell survival, and expelling drugs. Although several inhibitors targeting these proteins have been developed, their clinical use is often hampered by systemic toxicity, poor bioavailability, and resistance development. Nanoparticle-based drug delivery systems present a promising solution by improving drug solubility, stability, and targeted delivery. These systems leverage the Enhanced Permeation and Retention (EPR) effect to accumulate in tumor tissues, reducing off-target toxicity and increasing therapeutic efficacy. Co-encapsulation strategies involving anticancer drugs and resistance inhibitors within nanoparticles have shown potential in achieving coordinated pharmacokinetic and pharmacodynamic profiles. This review discusses the mechanisms of drug resistance, the limitations of current inhibitors, and the advantages of nanoparticle delivery systems in overcoming these challenges. By advancing these technologies, we can enhance treatment outcomes and move towards more effective cancer therapies.

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Redefining cancer research for therapeutic breakthroughs

Cited by 3 publications

References 33 publications

Comment on “Redefining cancer research for therapeutic breakthroughs”

Comment on “Redefining cancer research for therapeutic breakthroughs”

Principal Bioactive Properties of Oleanolic Acid, Its Derivatives, and Analogues

Overcoming Cancer Drug Resistance with Nanoparticle Strategies for Key Protein Inhibition

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