Progress in the Development of Matrix Metalloproteinase Inhibitors

Tu, Guogang; Xu, Wenfang; Huang, Huiming; Li, Shaohua

doi:10.2174/092986708784567680

Cited by 105 publications

(68 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…MeOH SHE, the most active sample according to current results, was suggested to be formed mostly with phenol-based compounds which are common bioactive substances of brown algae with health beneficial effects (Bhatnagar and Kim 2010) while H 2 O and n-BuOH SHE possibly contain more glycol-based compounds. Some MMP-inhibiting polysaccharides (Tu et al 2008) and benzopyran derivates from different sources were already isolated and reported while similar compounds were also found in S. horneri with different bioactivities. Nevertheless, current results indicated that S. horneri is a source for MMP inhibitors that might lead to future development of anti-tumor compounds.…”

Section: Discussionmentioning

confidence: 83%

Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts

Karadeniz

Lee

et al. 2018

Fish Aquatic Sci

View full text Add to dashboard Cite

Background: Matrix metalloproteinases (MMPs) are linked with several complications such as metastasis of cancer progression, oxidative stress, and hepatic fibrosis. Brown seaweeds are being extensively studied for their bioactive molecule content against cancer progression. In this context, Sargassum horneri was reported to possess various bioactivities including antiviral, antimicrobial, and anti-inflammatory partly due to its phenolic compound content.

show abstract

Section: Discussionmentioning

confidence: 83%

Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts

Karadeniz

Lee

et al. 2018

Fish Aquatic Sci

View full text Add to dashboard Cite

show abstract

“…Indeed, Rho-GTPase is frequently overexpressed in several cancers, whereby increased activity correlates with tumor progression and underlines the different modes of tumor cell motility during invasion and metastasis. The skill of tumor cells to switch between different modes of motility has been shown to limit the efficiency of agents aimed to reduce invasion (41). Recently, besides the well-known importance of mesenchymal motility in cancer cells invasion, growing evidence show the importance of proteolysis-independent movements in neoplastic cells (27,42,43).…”

Section: Discussionmentioning

confidence: 99%

EphA2 Induces Metastatic Growth Regulating Amoeboid Motility and Clonogenic Potential in Prostate Carcinoma Cells

Taddei

Parri

Angelucci

et al. 2011

Molecular Cancer Research

View full text Add to dashboard Cite

EphA2 kinase regulates cell shape, adhesion, and motility and is frequently overexpressed in several cancers, including melanoma, prostate, breast, and colon cancers and lung carcinoma. Although a function in both tumor onset and metastasis has been proposed, the role played by EphA2 in tumor progression is still debated. In melanoma, EphA2 has been reported to affect cell migration and invasiveness allowing cells to move by a proteolysis-independent strategy, commonly referred as amoeboid motility. With the aim to understand the role of EphA2 in prostate cancer metastatic spreading, we stably silenced EphA2 expression in a model of aggressive metastatic prostate carcinoma. Our results show that EphA2 drives the metastatic program of prostate carcinoma, although its involvement greatly differs among metastatic steps. Indeed, EphA2 expression (i) greatly affects prostate carcinoma cell motility style, guiding an amoeboid movement based on Rho-mediated cell rounding and independent from metalloprotases, (ii) is ineffective on transendothelial migration, adhesion onto extracellular matrix proteins, and on resistance to anoikis, (iii) regulates clonogenic potential of prostate carcinoma, thereby increasing anchorage-independent growth and self-renewal, prostasphere formation, tumor onset, dissemination to bone, and growth of metastatic colonies. Our finding indicate that EphA2-overexpressing prostate carcinoma cells gain an invasive benefit from their amoeboid motility style to escape from primary tumors and then, enhancing their clonogenic potential successfully target bone and grow metastases, thereby acknowledging EphA2 as a target for antimetastatic therapy of aggressive prostate cancers. Mol Cancer Res; 9(2); 149-60. Ó2011 AACR.

show abstract

“…MMP inhibitors have been used in a number of different therapeutic contexts to block excess MMP activity (42). In previous studies, MMP inhibitors prevented CD16 downmodulation but did not impact CD107a expression following stimulation with K562 cells (19,20).…”

Section: Mmp Expression Is Elevated In Chronic Hiv-1 Infectionmentioning

confidence: 99%

Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection

Liu

Sun

Rihn

et al. 2009

J Virol

102

View full text Add to dashboard Cite

Increasing evidence suggests that NK cells not only are critical in the initial host defense against pathogens but also may contribute to continued protection from human immunodeficiency virus type 1 (HIV-1) disease progression. NK cell cytolysis can be induced directly through diverse receptor families or can be induced indirectly through Fc receptors by antibodies mediating antibody-dependent cellular cytotoxicity (ADCC). ADCC has been implicated in both protection from simian immunodeficiency virus infection and slower progression of HIV-1 disease. ADCC activity declines with advancing infection, and yet the underlying mechanism for this dysfunction has not been defined, nor has it been determined whether the activity can be reconstituted. Here we demonstrate that NK cell-mediated ADCC is severely compromised in chronic HIV infection. The potency of ADCC function was directly correlated with baseline Fc␥RIIIa receptor (CD16) expression on NK cells. CD16 expression was negatively influenced by elevated expression of a group of enzymes, the matrix metalloproteinases (MMPs), normally involved in tissue/receptor remodeling. Inhibition of MMPs resulted in increased CD16 expression and augmented ADCC activity in response to antibody-coated target cells. These data suggest that MMP inhibitors may improve NK cell-mediated ADCC, which may provide subjects with an opportunity to harness the cytolytic power of NK cells through naturally occurring nonneutralizing HIV-specific antibodies.

show abstract

Progress in the Development of Matrix Metalloproteinase Inhibitors

Cited by 105 publications

References 0 publications

Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts

Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts

EphA2 Induces Metastatic Growth Regulating Amoeboid Motility and Clonogenic Potential in Prostate Carcinoma Cells

Matrix Metalloprotease Inhibitors Restore Impaired NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Human Immunodeficiency Virus Type 1 Infection

Contact Info

Product

Resources

About