Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts

Karadeniz, Fatih; Lee, Seulgi; Oh, Jung Hwan; Kim, Jung-Ae; Kong, Chang‐Suk

doi:10.1186/s41240-018-0093-0

Cited by 11 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These facts indicated that the relatively lipophilic compounds tended to be responsible for the anti-inflammatory activity. This was supported by several other studies showing a similar tendency that a relatively lipophylic extract or fraction has a promising anti-inflammatory effect [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33].…”

Section: Sargassum Species Are a Source Of Anti-inflammatory Agentssupporting

confidence: 75%

“…wightii were effective in inhibiting the COX-2 enzyme activity. Several other compounds that are allegedly responsible for the anti-inflammatory activity of the non-polar fraction include fucoxanthin or its derivatives [33], fucosterol or other steroid compounds [20,23,28,29,31,33,51], and phenolic compounds [18,23,30,31,33]. Although phenolic compounds are commonly known to have hydrophilic natures, their polarities will actually depend on their chemical structures.…”

Section: Sargassum Species Are a Source Of Anti-inflammatory Agentsmentioning

confidence: 99%

See 1 more Smart Citation

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

et al. 2019

View full text Add to dashboard Cite

Sargassum is recognized both empirically and scientifically as a potential anti-inflammatory agent. Inflammation is an important response in the body that helps to overcome various challenges to body homeostasis such as microbial infections, tissue stress, and certain injuries. Excessive and uncontrolled inflammatory conditions can affect the pathogenesis of various diseases. This review aims to explore the potential of Sargassum's anti-inflammatory activity, not only in crude extracts but also in sulfated polysaccharides and purified compounds. The tropical region has a promising availability of Sargassum biomass because its climate allows for the optimal growth of seaweed throughout the year. This is important for its commercial utilization as functional ingredients for both food and non-food applications. To the best of our knowledge, studies related to Sargassum's anti-inflammatory activity are still dominated by subtropical species. Studies on tropical Sargassum are mainly focused on the polysaccharides group, though there are some other potentially bioactive compounds such as polyphenols, terpenoids, fucoxanthin, fatty acids and their derivatives, typical polar lipids, and other groups. Information on the modulation mechanism of Sargassum's bioactive compounds on the inflammatory response is also discussed here, but specific mechanisms related to the interaction between bioactive compounds and targets in cells still need to be further studied.

show abstract

Section: Sargassum Species Are a Source Of Anti-inflammatory Agentssupporting

confidence: 75%

Section: Sargassum Species Are a Source Of Anti-inflammatory Agentsmentioning

confidence: 99%

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Results of this study proved a significant suppression of MMP-2 and MMP-9 level by CA with Cal treatment compared to CA and Cal alone treated cells. In the previous report [ 33 ], they observed that SHE inhibited both MMP activity and was illustrated as a ratio to that of activation of MMP-2 from pro-MMP-2. This reflects the regulatory dynamic between MMP-2 and MMP-9.…”

Section: Discussionmentioning

confidence: 98%

Capric Acid Behaves Agonistic Effect on Calcitriol to Control Inflammatory Mediators in Colon Cancer Cells

Negm

Sedky

2022

Molecules

View full text Add to dashboard Cite

Inflammation prompts cancer development and promotes all stages of tumorigenesis. Calcitriol is a nutraceutical essential regulator for host health benefits. However, the influence of calcitriol on inflammatory mediators involved in cancer cells is not clear. This study aimed to assess the sensitivity of calcitriol alone and combined with capric acid, and identify the possible influence of calcitriol on inflammatory mediators. The colorectal cancer cell line (HCT116) was induced by LPS/TNF-α and the inflammation and metastatic mediators (IL-1β, IL-6, IL-17) were quantified in calcitriol and capric acid supplemented colon cancer cells. The mRNA and protein expression of MMP-2, NF-κB and COX-2 were quantified. The significant reduction in MMP-2 expression was confirmed at combination treatment by zymogram analysis. Our findings demonstrated the anti-inflammatory and anti-metastatic potentials of capric acid and calcitriol in individual exposure in a combination of human colon cancer cell lines (HCT116). These abilities may be due to the inhibition of COX-2 mediators and NF-κB transcription factor and reciprocally regulated MMP-2 and MMP-9 signaling pathways. These findings elucidate the activation of COX-2 and NF-κB via disruption of the cellular outer matrix could be considered a novel molecular target suitable for colorectal cancer therapy. This study confirmed that capric acid activates calcitriol sensitization in colon cancer cells and could be used as a successful supplement for intestinal diseases and colon aberrations.

show abstract

“…Several studies on Sargassum summarized by Saraswati et al [ 6 ] indicated the promising anti-inflammatory effect of this seaweed genus, for both acute and chronic conditions. Although several screening studies demonstrated the predominance of Sargassum lipid-soluble fractions which are responsible for inflammatory activity [ 7 , 8 , 9 , 10 ], the potency of the lipid-soluble compounds of tropical Sargassum has not been fully explored. To date of our knowledge, the sulfated polysaccharides of tropical Sargassum are the most studied compounds for their anti-inflammatory activity [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Screening of In-Vitro Anti-Inflammatory and Antioxidant Activity of Sargassum ilicifolium Crude Lipid Extracts from Different Coastal Areas in Indonesia

et al. 2021

View full text Add to dashboard Cite

Sargassum brown seaweed is reported to exhibit several biological activities which promote human health, such as anticancer, antimicrobial, antidiabetic, anti-inflammatory, and antioxidant activity. This study aimed to investigate the anti-inflammatory and antioxidant activity of crude lipid extracts of Sargassum ilicifolium obtained from four different coastal areas in Indonesia, namely Awur Bay–Jepara (AB), Pari Island–Seribu Islands (PI), Sayang Heulang Beach–Garut (SHB), and Ujung Genteng Beach–Sukabumi (UGB). Results showed that treatment of RAW 264.7 macrophage cells with UGB and AB crude lipid extracts (12.5–50 µg/mL) significantly suppressed the nitric oxide production after lipopolysaccharide stimulation, both in pre-incubated and co-incubated cell culture model. The anti-inflammatory effect was most marked in the pre-incubated cell culture model. Both two crude lipid extracts showed 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and high ferric reducing antioxidant power, which were amounted to 36.93–37.87 µmol Trolox equivalent/g lipid extract and 681.58–969.81 µmol FeSO4/g lipid extract, respectively. From this study, we can conclude that crude lipid extract of tropical S. ilicifolium can be further developed as a source of anti-inflammatory and antioxidant agent.

show abstract

Inhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts

Cited by 11 publications

References 20 publications

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

Sargassum Seaweed as a Source of Anti-Inflammatory Substances and the Potential Insight of the Tropical Species: A Review

Capric Acid Behaves Agonistic Effect on Calcitriol to Control Inflammatory Mediators in Colon Cancer Cells

Screening of In-Vitro Anti-Inflammatory and Antioxidant Activity of Sargassum ilicifolium Crude Lipid Extracts from Different Coastal Areas in Indonesia

Contact Info

Product

Resources

About