Progress in protecting vestibular hair cells

Jiang, Luoying; Zheng, Zhiwei; He, Yingzi

doi:10.1007/s00204-021-03067-3

Cited by 7 publications

(5 citation statements)

References 108 publications

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“…One part of the vestibular system is the vestibular hair cell, which serves as a mechanosensory receptor. Anthocyanins protect vestibular hair cells from damage by inhibiting reactive oxygen species production and caspase-3 activation ( 23 ).…”

Section: Resultsmentioning

confidence: 99%

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Lubis,

Dewi,

Supriyan

et al. 2024

Biomed Rep

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Roselle calyces ( Hibiscus sabdariffa L.) is a plant that contains anthocyanin and flavonoids, which function as exogenous antioxidants for the human body to counteract excess oxidative stress. Roselle has anti-hypertensive, anti-cancer and anti-diabetic effects. The present study evaluated roselle to see whether it affects physical fitness. The components of physical fitness include strength, balance, right and left hand grip, vertical jump and VO 2max (maximum oxygen consumption). A total of 30 subjects received 200 ml rosella tea for 30 days every morning and evening. Every week, subjects were assessed for physical fitness. Data analysis used paired t and Wilcoxon test according to the normality test results. The results showed significant improvements in strength (from 24.9 to 27.3 kg; P=0.025), balance (from 23.3 to 42.2 sec; P=0.004), right (from 31.8 to 35.1 kg; P<0.0001) and left hand grip (from 29.8 to 31.6 kg; P=0.020), vertical jump (from 38.6 to 41.1 m/sec; P=0.008) and VO 2max (from 31.1 to 34.3 ml/kg/min; P=0.014). This demonstrated that roselle significantly improved six parameters of physical fitness and may be used as a supplement to improve physical fitness without severe side effects.

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Section: Resultsmentioning

confidence: 99%

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Lubis,

Dewi,

Supriyan

et al. 2024

Biomed Rep

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show abstract

“…In addition to military personal protective equipment, there are several promising therapeutic approaches that might also afford some prevention of vestibular injury. Jiang et al [37] conducted a review on protection of vestibular hair cells. Promising strategies for preventing loss or damage of vestibular hair cells include pharmacotherapy (such as induction of heat shock proteins, antioxidant treatments, use of antiapoptotic agents, use of insulin-like growth factor-1, use of other protective agents or molecules, or a combination of different drugs) or gene therapy [37].…”

Section: Preventionmentioning

confidence: 99%

Leveraging Technology for Vestibular Assessment and Rehabilitation in the Operational Environment: A Scoping Review

Hoppes,

Lambert,

Whitney

et al. 2024

Bioengineering

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Introduction: The vestibular system, essential for gaze and postural stability, can be damaged by threats on the battlefield. Technology can aid in vestibular assessment and rehabilitation; however, not all devices are conducive to the delivery of healthcare in an austere setting. This scoping review aimed to examine the literature for technologies that can be utilized for vestibular assessment and rehabilitation in operational environments. Materials and Methods: A comprehensive search of PubMed was performed. Articles were included if they related to central or peripheral vestibular disorders, addressed assessment or rehabilitation, leveraged technology, and were written in English. Articles were excluded if they discussed health conditions other than vestibular disorders, focused on devices or techniques not conducive to the operational environment, or were written in a language other than English. Results: Our search strategy yielded 32 articles: 8 articles met our inclusion and exclusion criteria whereas the other 24 articles were rejected. Discussion: There is untapped potential for leveraging technology for vestibular assessment and rehabilitation in the operational environment. Few studies were found in the peer-reviewed literature that described the application of technology to improve the identification of central and/or peripheral vestibular system impairments; triage of acutely injured patients; diagnosis; delivery and monitoring of rehabilitation; and determination of readiness for return to duty. Conclusions: This scoping review highlighted technology for vestibular assessment and rehabilitation feasible for use in an austere setting. Such technology may be leveraged for prevention; monitoring exposure to mechanisms of injury; vestibular-ocular motor evaluation; assessment, treatment, and monitoring of rehabilitation progress; and return-to-duty determination after vestibular injury. Future Directions: The future of vestibular assessment and rehabilitation may be shaped by austere manufacturing and 3D printing; artificial intelligence; drug delivery in combination with vestibular implantation; organ-on-chip and organoids; cell and gene therapy; and bioprinting.

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“…Cisplatin is a widely used anticancer agent with toxic effects on the sensory epithelia in the vestibular and cochlear systems. It has been reported not only to induce a marked decrease in hair cell density in the utricle, saccule, and ampullae, but also to result in an abnormal morphology and disorganization of the VHCs and their stereocilia bundles ( 126 ). Other substances, such as organic solvents, have toxic effects on the parts of the brain responsible for processing balance information, rather than on the vestibular system itself ( 127 ).…”

Section: Vestibular Disorders Associated With Hearing Loss: Diversity...mentioning

confidence: 99%

Vestibular Deficits in Deafness: Clinical Presentation, Animal Modeling, and Treatment Solutions

2022

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The inner ear is responsible for both hearing and balance. These functions are dependent on the correct functioning of mechanosensitive hair cells, which convert sound- and motion-induced stimuli into electrical signals conveyed to the brain. During evolution of the inner ear, the major changes occurred in the hearing organ, whereas the structure of the vestibular organs remained constant in all vertebrates over the same period. Vestibular deficits are highly prevalent in humans, due to multiple intersecting causes: genetics, environmental factors, ototoxic drugs, infections and aging. Studies of deafness genes associated with balance deficits and their corresponding animal models have shed light on the development and function of these two sensory systems. Bilateral vestibular deficits often impair individual postural control, gaze stabilization, locomotion and spatial orientation. The resulting dizziness, vertigo, and/or falls (frequent in elderly populations) greatly affect patient quality of life. In the absence of treatment, prosthetic devices, such as vestibular implants, providing information about the direction, amplitude and velocity of body movements, are being developed and have given promising results in animal models and humans. Novel methods and techniques have led to major progress in gene therapies targeting the inner ear (gene supplementation and gene editing), 3D inner ear organoids and reprograming protocols for generating hair cell-like cells. These rapid advances in multiscale approaches covering basic research, clinical diagnostics and therapies are fostering interdisciplinary research to develop personalized treatments for vestibular disorders.

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Progress in protecting vestibular hair cells

Cited by 7 publications

References 108 publications

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Roselle (Hibiscus sabdariffa L.) calyces tea improves physical fitness of healthy adults

Leveraging Technology for Vestibular Assessment and Rehabilitation in the Operational Environment: A Scoping Review

Vestibular Deficits in Deafness: Clinical Presentation, Animal Modeling, and Treatment Solutions

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